1971
DOI: 10.1016/0006-8993(71)90284-8
|View full text |Cite
|
Sign up to set email alerts
|

Apomorphine-induced aggression in the rat

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

4
17
1

Year Published

1973
1973
1990
1990

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 88 publications
(22 citation statements)
references
References 20 publications
4
17
1
Order By: Relevance
“…This was not unexpected, since the behavior of FRL rats generally does not differ from that of the parent. Sprague-Dawley strain and the latter, according to original observations of McKenzie [21], do not react with aggression to apomorphine. It appears that genetic selection for increased sensitivity to cholinergic stimulation has resulted in a profoundly en hanced responsiveness to affective aggression-eliciting stimuli.…”
Section: Discussionmentioning
confidence: 99%
“…This was not unexpected, since the behavior of FRL rats generally does not differ from that of the parent. Sprague-Dawley strain and the latter, according to original observations of McKenzie [21], do not react with aggression to apomorphine. It appears that genetic selection for increased sensitivity to cholinergic stimulation has resulted in a profoundly en hanced responsiveness to affective aggression-eliciting stimuli.…”
Section: Discussionmentioning
confidence: 99%
“…For example, the capacity of apomorphine to in duce aggressive behavior in nonmanipulated ani mals (13,20,21) is greatly potentiated during withdrawal from chronic haloperidol (9) and morphine (10,15) administration. Several as pects of the stereotyped behavior induced by apomorphine are also enhanced by previous manipulations of animals, such as pretreatment with catecholamine-depleting drugs (8,25), withdrawal from previous neuroleptic treat ment (18,19,22), and lesions of nigrostriatal pathway (7,12).…”
Section: Discussionmentioning
confidence: 99%
“…The difference between this finding and the lack of an effect on spontaneous aggression in the present study could possibly reflect a species difference in response to lead exposure. However, Cutler (4) considered a variety of aggressive behaviors as measured during a 5-inin period, while the present study was concerned only with boxing, the characteristic response of male rat pairs to apomorphine (8,14). Hastings et al (10) have reported reduced levels of shock-induced aggression in rats neonatally ex posed to lead.…”
Section: Discussionmentioning
confidence: 94%
“…However, Cutler (4) found male leadexposed mice to exhibit a significantly lower incidence of aggressive behaviors. In addition to stereotypy (3), apomorphine, a dopamine re ceptor agonist, has been reported to induce marked and severe aggression in adult male rat pairs (8,14,20). Therefore, the present study was concerned with the evaluation of apomorphine-induced aggression and stereotypy in adult rats exposed to lead during early post natal development.…”
mentioning
confidence: 99%