Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their recovery from stress-induced ulcers

Degen, Saskia; Geven, E.J.; Sluyter, Frans; Hof, M.; Elst, Martine C.J. van der; Cools, Alexander R.

doi:10.1016/s0024-3205(02)02362-7

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Not only this, but it is also reported that DA mediates gastric cytoprotective effects on other neurotransmitters [18, 19]. Now, it is well established that stress induced ulcerogenesis is governed by activation of the mesocorticolimbic DA systems [15–20]. Alterations of DA levels and total ulcer score in acute and chronic unpredictable stress models have been summarized in Table 1.…”

Section: Introductionmentioning

confidence: 96%

Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers: Short Review

Rasheed

Alghasham

2012

Advances in Pharmacological Sciences

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For decades, it has been suggested that dysfunction of dopaminergic pathways and their associated modulations in dopamine levels play a major role in the pathogenesis of neurological disorders. Dopaminergic system is involved in the stress response, and the neural mechanisms involved in stress are important for current research, but the recent and past data on the stress response by dopaminergic system have received little attention. Therefore, we have discussed these data on the stress response and propose a role for dopamine in coping with stress. In addition, we have also discussed gastric stress ulcers and their correlation with dopaminergic system. Furthermore, we have also highlighted some of the glucocorticoids and dopamine-mediated neurological disorders. Our literature survey suggests that dopaminergic system has received little attention in both clinical and preclinical research on stress, but the current research on this issue will surely identify a better understanding of stressful events and will give better ideas for further efficient antistress treatments.

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Section: Introductionmentioning

confidence: 96%

Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers: Short Review

Rasheed

Alghasham

2012

Advances in Pharmacological Sciences

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“…Numerous studies have shown that dopamine agonists such as bromocriptine, apomorphine L-Dopa and others, as well as dopamine antagonists such as haloperidol, domperidon, sulpirid etc., play a role in the modulation of stress ulcers, through dopamine receptors, both peripherally and centrally [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers

Popović

Janićijević-Hudomal²,

Kaurinović

et al. 2009

Molecules

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The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays were used and the resulting data was statistically analyzed. Alcohol stress caused gastric ulcerations and hemorrhages and changed all the examined parameters except glutathione peroxidase activity. All drugs reduced the ulcer index and hemorrhages, with azithromycin showing the strongest effects. The drugs in combination with alcohol showed different effects on biochemical parameters. Our results indicate that the gastroprotective effects of the investigated drugs on experimental lesions induced by 100% ethanol could not be correlated with their antioxidative properties.

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“…Thus, increasing levels of NO by bromocriptine may be involved in protective effects on gastric mucosa [84]. Less and shorter-lasting stress-induced increases of corticosterone can explain recovery from a gastric ulcer by apomorphine [85]. Finally, modulation of dopaminergic levels by neurons located within the substantia nigra may play an important role in the development of gastric erosions [86].…”

Section: Dopamine Stomach Story After 1990mentioning

confidence: 99%

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Sikiric,

Boban Blagaic,

Krezic

et al. 2023

Pharmaceuticals

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We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients. Szabo’s cysteamine duodenal ulcer as the dopamine duodenal healing and cysteamine as a dopamine antagonist signifies the dopamine agonists anti-ulcer effect and dopamine antagonists ulcerogenic effect. From these viewpoints, we focused on dopamine and gastric ulcer healing. We mentioned antecedent studies on the dopamine presence in the stomach and gastric juice. Then we reviewed, in the timeline, therapy significance arising from the anti-ulcer potency of the various dopamine agonists, which is highly prevailing over the quite persistent beneficial evidence arising from the various dopamine antagonists. Meanwhile, the beneficial effects of several peptides (i.e., amylin, cholecystokinin, leptin, and stable gastric pentadecapeptide BPC 157, suggested as an acting mediator of the dopamine brain-gut axis) were included in the dopamine gastric ulcer story. We attempt to resolve dopamine agonists/antagonists issue with the dopamine significance in the stress (cysteamine as a prototype of the duodenal stress ulcer), and cytoprotection (cysteamine in small dose as a prototype of the cytoprotective agents; cysteamine duodenal ulcer in gastrectomized rats). Thereby, along with dopamine agonists’ beneficial effects, in special circumstances, dopamine antagonists having their own ulcerogenic effect may act as “mild stress (or)” or “small irritant” counteracting subsequent strong alcohol or stress procedure-induced severe lesions in this particular tissue. Finally, in the conclusion, as a new improvement in further therapy, we emphasized the advantages of the dopamine agents’ application in lower gastrointestinal tract therapy.

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Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their recovery from stress-induced ulcers

Cited by 6 publications

References 27 publications

Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers: Short Review

Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers: Short Review

Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

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