Apoptosis and disease: a matter of cell fate

Hague, Angela; Paraskeva, Christos

doi:10.1038/sj.cdd.4401497

Cited by 26 publications

(14 citation statements)

References 37 publications

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“…Apoptosis plays a pivotal role both in fetal development and in adult organisms, where it contributes to the maintenance of normal cellular homeostasis and efficiency of the immune system (Opferman and Korsmeyer 2003;Marsden and Strasser 2003). Many evidences suggest that defects in the mechanisms of apoptosis are involved in several multifactorial diseases (Hague and Paraskeva 2004).…”

Section: Introductionmentioning

confidence: 99%

Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis

Pace

Bellizzi

Giordano

et al. 2010

Cell Stress and Chaperones

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Apoptosis is a programmed cell death process, whose complexity led researchers to build mathematical models that could help to identify its crucial steps. In previous works, we theoretically analyzed and numerically simulated a model that describes a pathway from an external stimulus to caspase-3 activation. Here, the results of experiments performed on populations of synchronized cells treated with the inducer Apo2L/TRAIL are reported and are compared with model predictions. In particular, we have compared in vitro and in silico results relevant to the time evolutions of caspase-3 and caspase-8 activities, as well as of the dead cells fractions. In addition, the effect of the BAR gene silencing was evaluated. Caspase-3 activation and cell death is faster in silenced than in nonsilenced cells, thus confirming previous simulation results. Interestingly, Apo2L/TRAIL treatment in itself reduces the BAR gene expression. The qualitative agreement between model predictions and cell cultures behavior suggests that the model captures the essential features of the biological process and could be a tool in further studies of caspases activation. In this manuscript, we report the results of in vitro experiments aimed at revealing the dynamics of caspase activation in a cell population. A qualitative agreement between these results and a mathematical model describing a pathway from an external stimulus to caspase-3 activation was obtained, thus showing that the model captures the essential features of the biological process and may be a reliable tool in further studies of caspase activation.

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Section: Introductionmentioning

confidence: 99%

Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis

Pace

Bellizzi

Giordano

et al. 2010

Cell Stress and Chaperones

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“…Malfunctions of apoptosis have been implicated in many forms of human diseases [20, 21]. The potential role of the Fas receptor pathway in asthma has been intensively studied during recent years, albeit with contradictory results.…”

Section: Discussionmentioning

confidence: 99%

“…Very little cytoplasmtic material is released into the intercellular space and no or limited inflammation is caused in neighboring tissues. In contrast, during necrosis, the cellular contents are released uncontrolled into the cell's environment which results in damage of surrounding cells and a strong inflammatory response in the corresponding tissue [20, 21]. Based on previous reports, lung diseases are related to inflammatory processes that generate increased reactive oxygen species that correlate with disease severity [44–46].…”

Section: Discussionmentioning

confidence: 99%

The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

Pirzad

Jafari

Tavana

et al. 2010

Journal of Toxicology

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Sulfur mustard (SM) is an alkylating agent that induces apoptosis and necrosis in cells. Fas-Fas ligand (FasL) interaction could induce apoptosis as well. In this study, it was hypothesized that apoptosis might play an important role in the pathogenesis of SM-induced lung injury via Fas-FasL signaling pathway. In a case-control study, Fas and FasL levels, caspase-3 activity and percent of apoptotic cells were measured in bronchoalveolar lavage (BAL) fluid of patients 20 years after exposure to sulfur mustard and compared with the control group. Results show that Fas and FasL levels were significantly higher in BAL fluid cells in patients group compared with the control (P = .001). No significant differences were observed between mild and moderate-severe groups. BAL fluid cells caspase-3 activity was not significantly different among the mild, moderate-severe, and control groups. The data suggest that Fas-FasL-induced apoptosis was impaired in BAL fluid cells of SM-exposed patients which might be one of the initiators of pathogenesis in SM-induced lung injury in these patients.

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“…I3C has been reported to sensitize multidrug resistant tumors to chemotherapeutic drugs without any related toxicity [1,[62][63][64] . Mechanisms of anti-cancer and chemosensitizing effects of indole compounds were summarized in Figure 9.…”

Section: Indole Compounds For Chemosensitizationmentioning

confidence: 99%

“…Emerging evidence also documents the ability of indoles to reverse the process of EMT via regulation of key miRNAs. An efficient induction of apoptosis and reversal of EMT not only ensures increased sensitivity to conventional drugs (chemosensitization) but also results in significantly reduced invasion and metastasis [1,[62][63][64] .…”

Section: Indole Compounds For Chemosensitizationmentioning

confidence: 99%