Apoptosis as a Therapeutic Target in Cancer and Cancer Stem Cells: Novel Strategies and Futures Perspectives

García, María Ángel; Carrasco, Esther; Ramírez, Alberto; Jiménez, Gema; López-Ruiz, Elena; Perán, Macarena; Picón, Manuel; Campos, Joaquín M.; Boulaiz, Houría; Marchal, Juan Antonio

doi:10.5772/48267

Cited by 2 publications

(1 citation statement)

References 237 publications

(235 reference statements)

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“…This pathway can prompt apoptosis by different mechanisms, including disturbance of electron transport, oxidative phosphorylation, ATP transport, the release of proteins activating caspases, and changing cellular redox potential [42]. Enhanced mitochondrial membrane permeability and the release of cytochrome c, which is a pro‐apoptotic protein, and activators of caspase from the mitochondria into the cytosol all can lead to apoptosis [42]. In addition, mitochondria contribute to drug resistance [43].…”

Section: Critical Pathways Associated With Glioma Cells Growth and Re...mentioning

confidence: 99%

Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review

Abadi

Shahsavani

Faramarzpour

et al. 2021

Fundamemntal Clinical Pharma

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Glioblastoma multiforme (GBM) is known as the deadliest form of brain tumor. In addition, its high treatment resistance, heterogeneity, and invasiveness make it one of the most challenging tumors. Depression is a common psychological disorder among patients with cancer, especially GBM. Due to the high occurrence rates of depression in GBM patients and the overlap of molecular and cellular mechanisms involved in the pathogenesis of these diseases, finding antidepressants with antitumor effects could be considered as an affordable strategy for the treatment of GBM. Antidepressants exert their antitumor properties through different mechanisms. According to available evidence in this regard, some of them can eliminate the adverse effects resulting from chemo‐radiotherapy in several cancers along with their synergistic effects caused by chemotherapy. Therefore, providing comprehensive insight into this issue would guide scientists and physicians in developing further preclinical studies and clinical trials, in order to evaluate antidepressants' antitumor potential. Considering that no narrative review has been recently published on this issue, specifically on these classes of drugs, we present this article with the purpose of describing the antitumor cellular mechanisms of three classes of antidepressants as follows: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs) in GBM.

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Section: Critical Pathways Associated With Glioma Cells Growth and Re...mentioning

confidence: 99%

Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review

Abadi

Shahsavani

Faramarzpour

et al. 2021

Fundamemntal Clinical Pharma

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Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture

et al. 2022

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There is a global need to discover effective anti-cancerous compounds from natural sources. Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived polysaccharides. In this study, we evaluated the anti-cancer ability of seven fractions of wheat cell culture polysaccharides (WCCPSs) in the HCT-116 colon cancer cell line. Almost all (6/7) fractions had an inhibitory effect on the proliferation of colon cancer cells, and two fractions (A-b and A-f) had considerable therapeutic indexes. The WCCPS fractions induced cell cycle arrest in the G1 phase and induced different rates of apoptosis (≤48%). Transmission and scanning electron microscopy revealed that WCCPS fractions caused apoptotic changes in the nucleus and cytoplasm, including damage to mitochondria and external morphological signs of apoptosis. In addition, the WCCPSs induced an increase in the levels of Bax, cytochrome c, and caspases 8 and 3, indicating that cell death progressed through intrinsic and extrinsic pathways of apoptosis. Furthermore, some fractions caused a significant decrease of c-Myc, b-catenin, NFkB2, and HCAM (CD 44) levels, indicating enhanced cell differentiation. Thus, for the first time, our results provide a proof of concept of the anti-cancer capacity of WCCPS fractions in colorectal cancer.

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Apoptosis as a Therapeutic Target in Cancer and Cancer Stem Cells: Novel Strategies and Futures Perspectives

Cited by 2 publications

References 237 publications

Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review

Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review

Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture

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