Apoptosis in developmental and repair-related human tooth remodeling: A view from the inside

Mitsiadis, Thimios A.; Bari, Cosimo De; About, Imad

doi:10.1016/j.yexcr.2007.11.001

Cited by 68 publications

(59 citation statements)

References 39 publications

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“…Apoptosis is observed particularly in the subodontoblastic layer and pulp fibroblasts (Mitsiadis et al, 2008), indicating a role in pulp homeostasis (Nishikawa and Sasaki, 1999). The pulp is also eliminated by apoptosis during the process of physiological root resorption in primary teeth.…”

Section: Other Cell Populationsmentioning

confidence: 99%

Apoptotic Signaling in Mouse Odontogenesis

Matalová

Švandová

Tucker

2012

OMICS: A Journal of Integrative Biology

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Apoptosis is an important morphogenetic event in embryogenesis as well as during postnatal life. In the last 2 decades, apoptosis in tooth development (odontogenesis) has been investigated with gradually increasing focus on the mechanisms and signaling pathways involved. The molecular machinery responsible for apoptosis exhibits a high degree of conservation but also organ and tissue specific patterns. This review aims to discuss recent knowledge about apoptotic signaling networks during odontogenesis, concentrating on the mouse, which is often used as a model organism for human dentistry. Apoptosis accompanies the entire development of the tooth and corresponding remodeling of the surrounding bony tissue. It is most evident in its role in the elimination of signaling centers within developing teeth, removal of vestigal tooth germs, and in odontoblast and ameloblast organization during tooth mineralization. Dental apoptosis is caspase dependent and proceeds via mitochondrial mediated cell death with possible amplification by Fas-FasL signaling modulated by Bcl-2 family members.

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Section: Other Cell Populationsmentioning

confidence: 99%

Apoptotic Signaling in Mouse Odontogenesis

Matalová

Švandová

Tucker

2012

OMICS: A Journal of Integrative Biology

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“…Published November 12, 2010. Apoptosis is a form of programmed cell death that eliminates specific cells without disturbing tissue structure or function and is pivotal for the development and maintenance of multicellular organisms (1). It is necessary for morphogenesis during tooth development (2), and in the dentin formation process, odontoblasts undergo apoptosis to maintain an appropriate dentin deposition rate (3). Apoptosis also occurs in mature dental pulp (4) when the pulp is exposed to extrinsic stimuli such as bacterial infection, ischemia, mechanical stimuli, or dental material (5,6).…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro

Yang

Zhu

Cheng

et al. 2010

Braz J Med Biol Res

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“…Furthermore, calcification often occurs in parts of the pulp chamber and root canal, which results in a reduction in size of the pulp chamber caused by the continual secretion of dentin matrix by odontoblasts (24). Mitsiadis et al (25) showed that the dental pulp volume decreases gradually upon aging due to the continuous production of dentin matrix by odontoblasts and that this age-associated pulp chamber reduction is due to the elimination of a certain number of odontoblasts by apoptosis. These age-associated physiological changes explain, at least in part, the lower efficiency of DPSC line derivation from permanent teeth of aged donors.…”

Section: Discussionmentioning

confidence: 99%

Derivation and growth characteristics of dental pulp stem cells from patients of different ages

Zhou

et al. 2015

Molecular Medicine Reports

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Abstract. The dental pulp contains a relatively low number of stem cells; however, it is considered to be a promising source of stem cells for use in regenerative therapy. To date, it has remained elusive whether there are certain differences in the dental pulp stem cells (DPSCs) from donors of different ages. In the present study, DPSC lines were derived using teeth from children, adolescents, adults and aged donors. The derivation efficiency, the proliferative and apoptotic rate, cell marker expression and the differentiation capacity were investigated and compared among these DPSC lines. The derivation efficacy was decreased with increasing donor age. Although a large part of cell surface markers was expressed in all DPSC lines, the expression of CD29 was downregulated in the DPSCs from aged teeth. In addition, the doubling time of DPSCs from aged teeth was prolonged and the number of apoptotic cells was increased with the propagation. These DPSCs were able to differentiate into a neuronal linage, which positively expressed the neuron-specific class III beta-tubulin and microtubule-associated protein 2, as well as into an osteogenic lineage, which positively expressed CD45; however, these DPSCs from aged teeth were completely or partially deprived of differentiation capacity. By contrast, DPSCs from younger teeth displayed significantly higher vitality and a higher potential for use in dental regenerative medicine.

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Apoptosis in developmental and repair-related human tooth remodeling: A view from the inside

Cited by 68 publications

References 39 publications

Apoptotic Signaling in Mouse Odontogenesis

Apoptotic Signaling in Mouse Odontogenesis

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro

Derivation and growth characteristics of dental pulp stem cells from patients of different ages

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