Apoptosis in mammalian oocytes: a review

Tiwari, Meenakshi; Prasad, Shilpa; Tripathi, Anima; Pandey, Ashutosh; Ali, Irfan; Singh, Arvind Kumar; Shrivastav, Tulsidas G.; Chaube, Shail K.

doi:10.1007/s10495-015-1136-y

Cited by 192 publications

(196 citation statements)

References 72 publications

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“…3C,D). Many factors, including ROS, have been reported to induce oocyte apoptosis (Tiwari et al, 2015). Indeed, increased ROS levels were observed in Kat8…”

Section: Discussionmentioning

confidence: 98%

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Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating ROS levels

Yin

Jiang

et al. 2017

Development

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Proper oocyte development is crucial for female fertility and requires timely and accurate control of gene expression. K (lysine) acetyltransferase 8 (KAT8), an important component of the X chromosome dosage compensation system in Drosophila, regulates gene activity by acetylating histone H4 preferentially at lysine 16. To explore the function of KAT8 during mouse oocyte development, we crossed Kat8 flox/flox mice with Gdf9-Cre mice to specifically delete Kat8 in oocytes. Oocyte Kat8 deletion resulted in female infertility, with follicle development failure in the secondary and preantral follicle stages. RNA-seq analysis revealed that Kat8 deficiency in oocytes results in significant downregulation of antioxidant genes, with a consequent increase in reactive oxygen species. Intraperitoneal injection of the antioxidant N-acetylcysteine rescued defective follicle and oocyte development resulting from Kat8 deficiency. Chromatin immunoprecipitation assays indicated that KAT8 regulates antioxidant gene expression by direct binding to promoter regions. Taken together, our findings demonstrate that KAT8 is essential for female fertility by regulating antioxidant gene expression and identify KAT8 as the first histone acetyltransferase with an essential function in oogenesis.

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“…3C,D). Many factors, including ROS, have been reported to induce oocyte apoptosis (Tiwari et al, 2015). Indeed, increased ROS levels were observed in Kat8…”

Section: Discussionmentioning

confidence: 98%

“…Several factors can induce oocyte apoptosis in mammals, such as increased levels of reactive oxygen species (ROS) or destruction of oocyte-granulosa cell communication (Tiwari et al, 2015). However, how anti-apoptotic genes are regulated in response to these apoptosis inducers is still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating ROS levels

Yin

Jiang

et al. 2017

Development

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“…12.2). It is believed that apoptosis is the major mechanism involved in the loss of oocytes during cyst breakdown and primordial follicle assembly (reviewed by Tiwari et al 2015). Xu et al (2011) showed that proliferating cell nuclear antigen Fig.…”

Section: Assembly Of Primordial Folliclesmentioning

confidence: 99%

A Role of MicroRNAs in Cell Differentiation During Gonad Development

Grossman

Shalgi

2016

Results and Problems in Cell Differentiation

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MicroRNAs (miRNAs) are a group of small noncoding RNA molecules that play a major role in posttranscriptional regulation of gene expression and are expressed in an organ-specific manner. One miRNA can potentially regulate the expression of several genes, depending on cell type and differentiation stage. miRNAs are differentially expressed in the male and female gonads and have an organ-specific reproductive function. Exerting their affect through germ cells and gonadal somatic cells, miRNAs regulate key proteins necessary for gonad development. The role of miRNAs in the testes is only starting to emerge though they have been shown to be required for adequate spermatogenesis. Widely explored in the ovary, miRNAs were suggested to play a fundamental role in follicles' assembly, growth, differentiation, and ovulation. In this chapter, we focus on data obtained from mice in which distinct proteins that participate in the biosynthesis of miRNAs were conditionally knocked out from germ cells (spermatogonial cells or oocytes) or gonadal somatic cells (Sertoli or granulosa cells). We detail recent advances in identification of particular miRNAs and their significance in the development and function of male and female gonads. miRNAs can serve as biomarkers and therapeutic agents of pathological conditions; thus, elucidating the branched and complex network of reproduction-related miRNAs will aid understanding of gonads' physiology and managing reproduction disorders.

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“…That is, during oogenesis, not all meiotic defects drive cells to undergo apoptosis, making oocytes more susceptible to completing meiosis carrying chromosome defects [10]. When apoptosis does occur, both intrinsic and extrinsic pathways are involved in the death of the oocytes at various stages of meiotic prophase [11]. In contrast, spermatocytes with meiotic defects usually undergo apoptosis during pachynema, the transition of prophase I to metaphase I, and/or metaphase I [12].…”

Section: Introductionmentioning

confidence: 99%

Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins

2017

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Cyclin A1 (Ccna1), a member of the mammalian A type cyclins, is most abundantly expressed in spermatocytes and is essential for spermatogenesis in the mouse. Ccna1- deficient spermatocytes arrest at late meiotic prophase and undergo apoptosis. To further delineate the mechanisms and key factors involved in this process, we have examined changes in expression of genes involved in both intrinsic and extrinsic signaling pathways that trigger apoptosis in the mutant spermatocytes. Our results show that both pathways are involved, and that the factors involved in the intrinsic pathway were expressed earlier than those involved in the extrinsic pathway. We have also begun to identify in vivo Ccna1-interacting proteins, using an unbiased biochemical approach, and identified 14-3-3, a key regulator of apoptosis, as a Ccna1-interacting protein. Expression levels of 14-3-3 proteins remain unchanged between wild type and mutant testes but there were differences in the subcellular distribution. In wild type control, 14-3-3 is detected in both cytosolic and nuclear fractions whereas it is restricted to the cytoplasm in mutant testes. This differential distribution of 14-3-3 may contribute to the induction of apoptosis in Ccna1-deficient spermatocytes. These results provide insight into the apoptotic mechanisms and pathways that are triggered when progression through the meiotic cell cycle is defective in male gametogenesis.

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Apoptosis in mammalian oocytes: a review

Cited by 192 publications

References 72 publications

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating ROS levels

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating ROS levels

A Role of MicroRNAs in Cell Differentiation During Gonad Development

Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins

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