Apoptosis in the aged dog brain

Kiatipattanasakul, Wijit; Nakamura, Shinichiro; Hossain, Md. Maruf; Nakayama, Hiroyuki; Uchino, Tomiya; Shumiya, Seigou; Goto, Naoaki; Doi, Kunio

doi:10.1007/s004010050514

Cited by 66 publications

(32 citation statements)

References 29 publications

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“…Therefore, it is necessary for diagnose of age related degenerative diseases to evaluate age-associated changes in the brain. Various age-associated changes were detected in aged dogs with occasionally abnormal behaviors [4,6,10,27,30], like as those reported in human [13]. Although MRI has been applied in veterinary clinics and experimental medicine, several reports were on clinical cases and few reports on age-associated changes in the dog brain [5,37].…”

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confidence: 86%

Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Kimotsuki

Nagaoka

Yasuda

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. Age-associated changes of magnetic resonance imaging (MRI) on the brain were evaluated in 19 beagle dogs aged from 8-month-to 16-year-old. A significant correlation of the volume of lateral ventricle space was observed in the dogs with age advanced, however, no correlation was found between hippocampus size and the aging. The hypo-intensity areas on T2-weighted MRI were detected in globus pallidus and substantia nigra with a significant correlation of both intensity ratios to lateral ventricle with age advanced. These areas were coincided with the accumulation of iron in the slice of the brain with Perls' staining. In addition, hyperintensity area, suggesting perivascular demyelination with fluid-filled space, was also observed in white matter surrounding the lateral ventricle on T2-weighted MRI. These results suggested that age-associated changes of T2-weighted MRI were developed in the dog brain, especially in globus pallidus, substantia nigra, and white matter surrounding lateral ventricle, like as those reported in the human brain KEY WORDS: age-associated change, brain, canine, hypo-and hyper-intensity, MRI.J. Vet. Med. Sci. 67(10): 961-967, 2005 Magnetic resonance imaging (MRI) has been used as a noninvasive and useful diagnostic technique for evaluating age related brain disorders, such as Alzheimer's disease, Parkinson's disease, and dementia, indicating severe atrophy of the brain, hippocampus, amygdala, and temporal lobe, gray matter, and dilatation of ventricle space, and cortical sulci, [9,17,26,28,34]. However, age-associated similar changes of MRI was also observed in the clinically healthy human brain, indicating brain atrophy, dilatation of ventricle space and cortical sulci, hypo-intensity area in globus pallidus and substantia nigra, and hyper-intensity area in white matter [7,16,20,31]. In addition, age-associated pathological changes of the brain, including developments of senile plaque, decrease number of neuronal cell, deposit of lipofuscin, and activation of astrocyte, have also been well documented [8,12,23,38]. Therefore, it is necessary for diagnose of age related degenerative diseases to evaluate age-associated changes in the brain. Various age-associated changes were detected in aged dogs with occasionally abnormal behaviors [4,6,10,27,30], like as those reported in human [13]. Although MRI has been applied in veterinary clinics and experimental medicine, several reports were on clinical cases and few reports on age-associated changes in the dog brain [5,37]. This study deals with ageassociated changes in MRI on the brain, especially lateral ventricle space, hippocampus size, and hypo-and hyperintensity area, in beagle dogs with age advanced. MATERIALS AND METHODS Animals:Clinically healthy 19 beagle dogs (8 male and 11 female), aged from 8-month-to 16-year-old, were used. All the dogs were bred, reared, and kept in Medicinal Safety Research Laboratories, Sankyo Co., Ltd. under the condition of circumstance temperature at 22 ± 2°C. The air extraction was designed to be 10...

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confidence: 86%

Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Kimotsuki

Nagaoka

Yasuda

et al. 2005

The Journal of Veterinary Medical Science

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“…However, this correlation is not linear because the ventricular volume gradually increases until the age of 10, after which the increase is much more pronounced. This pronounced increase is associated with brain aging atrophy, which induces ventricular system enlargement [43][44][45][46][47]. In addition, significant differences were seen between the specimen's body weight and the LVV, as reported by Vite et al [38].…”

Section: Discussionmentioning

confidence: 92%

Comparison between ultrasonography and computed tomography images for planning and neuronavigation in brain surgeries in dogs as an animal model

Carreira

Universitário²,

Ajuda³

2015

Glob Anesth Perioper Med

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Objectives: The brain's inner cavities containing cerebrospinal fluid are referred to as ventricles, which are easily identified in an ultrasonographic (US) image as hypoecogenic and in computed tomography (CT) as hypodense. Imaging has become essential to planning and neuronavigation in brain surgeries, serving to guide the surgeon through the organ. The study aimed to 1) compare ultrasonography (US) and computed tomography (CT) measurements of lateral ventricle volumes (LVV) in dogs to determine their level of agreement and 2) understand their influence on surgical planning and neuronavigation. Materials and methods:Measurements were taken from a sample of 24 LVVs from 12 brachycephalic dog cadavers. First, 2 mm slices of the dogs' brains were scanned with the CT machine. The US brain scan technique was performed using a transducer of 7.5 MHz over the brain after craniotomy placement. This procedure was useful in simulating the brain neuronavigation technique in a two-dimensional scenario. A P value less than 0.05 was defined as statistically significant. Results:A comparison of the US and CT images showing measurements of the right and left LVVs showed no statistically significant differences between the LVVs, allowing us to conclude that US is a reliable technique to planning and neuronavigation in brain surgeries. Conclusion:As a result US is of great value in the everyday practice and areas working with limited resources such as in veterinary medicine, or even in a zooubitquity context, since in some human's hospitals of developing countries or in some rural and remote areas, access to CT, magnetic resonance MR techniques, and neuronavigation systems are limited to point high-technology centers, unlike the sonography (US). Therefore, US it is a reliable technique to planning and neuronavigation in brain surgeries, thus promoting patient safety and surgeon success.

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“…In this study, we attempted to apply the diagnostic criteria for dementia in dogs based on behavior, which are employed in some clinics in Japan. 23 However, they could not be used for cheetahs, which are particularly fierce animals. Therefore, cognitive dysfunction of the 2 cheetahs were diagnosed subjectively by the clinician, who had been treating these cheetahs for a long period.…”

Section: Discussionmentioning

confidence: 99%

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

2011

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Alzheimer disease is a dementing disorder characterized pathologically by Ab deposition, neurofibrillary tangles, and neuronal loss. Although aged animals of many species spontaneously develop Ab deposits, only 2 species (chimpanzee and wolverine) have been reported to develop Ab deposits and neurofibrillary tangles in the same individual. Here, the authors demonstrate the spontaneous occurrence of Ab deposits and neurofibrillary tangles in captive cheetahs (Acinonyx jubatus). Among 22 cheetahs examined in this study, Ab deposits were observed in 13. Immunostaining (AT8) revealed abnormal intracellular tau immunoreactivity in 10 of the cheetahs with Ab deposits, and they were mainly distributed in the parahippocampal cortex and CA1 in a fashion similar to that in human patients with Alzheimer disease. Ultrastructurally, bundles of straight filaments filled the neuronal somata and axons, consistent with tangles. Interestingly, 2 of the cheetahs with the most severe abnormal tau immunoreactivity showed clinical cognitive dysfunction. The authors conclude that cheetahs spontaneously develop age-related neurodegenerative disease with pathologic changes similar to Alzheimer disease.

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Apoptosis in the aged dog brain

Cited by 66 publications

References 29 publications

Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Comparison between ultrasonography and computed tomography images for planning and neuronavigation in brain surgeries in dogs as an animal model

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

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