Apoptosis in the kidneys of rats that experienced intrauterine growth restriction

He, Xiaofeng; Xie, Zijian; Dong, Qin; Chen, Ping-Yang; Hu, Jingping; Wang, Tao

doi:10.1111/nep.12340

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…Pregnant rats were randomly divided into a control group (CON), an IUGR group (IUGR) and an L-Arg group (LA). The establishment of the IUGR model was conducted as described in our previous studies with modifications (14,15). The pregnant rats in the CON group were fed a 21% protein diet (normal feed) and normal water during pregnancy and lactation.…”

Section: Methodsmentioning

confidence: 99%

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

Luo

Chen

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the response of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats to dietary L-arginine (L-Arg) supplementation during the lactation period early in life. Pregnant Sprague-Dawley rats were randomly divided into a control group (CON), an intrauterine growth restriction group (IUGR) and an L-Arg group (LA). The pregnant rats in the CON group were fed a 21% protein diet, and those in the IUGR and LA groups were fed a 10% low protein diet, and all rats were fed a 21% protein diet after delivery. Water was available ad libitum to the pregnant rats during the 21-day lactation period, and the water provided to the LA group included 200 mg/kg/day L-Arg. Blood glucose, serum insulin, homeostasis model of assessment for insulin resistance (HOMA-IR), PI3K and protein kinase B (PKB) protein expression, and phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) mRNA expression in the offspring rats were measured postnatally at 1, 3 and 8 weeks. No significant difference in blood glucose, serum insulin and HOMA-IR were identified at any time point among the three groups. PI3K and PKB expression was lower in the IUGR group offspring compared with that in the CON group offspring, but both were increased by dietary L-Arg supplementation. PEPCK mRNA and G-6-Pase mRNA expression levels in the offspring of the IUGR group were higher compared with those in the CON group but were downregulated following L-Arg supplementation. These results suggest that dietary L-Arg supplementation during the early lactation period promoted catch-up growth and reversed abnormalities in hepatic insulin signaling and gene expression of gluconeogenic enzymes in IUGR offspring rats.

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Section: Methodsmentioning

confidence: 99%

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

Luo

Chen

et al. 2017

Experimental and Therapeutic Medicine

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“…These alterations may heighten the risk of cardiovascular disease among infants with intrauterine growth restriction in the later stages [6]. Additionally, since infants with growth restriction exhibit reduced growth rates and lower numbers of nephrons than infants with normal birth weight, relevant animal models have con rmed this observation [7]. Moreover, due to premature birth and insu cient intrauterine growth time, the expression levels of various active substances and related factors on the lung surface are low, impeding lung development and maturation, subsequently impacting respiratory function.…”

Section: Discussionmentioning

confidence: 99%

A case of Pierre Robin sequence in a child with multiple organ dysfunction

Pan,

Pan

2024

Preprint

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The Pierre Robin sequence (PRS) has an incidence rate of 1/20000 ~ 1/8500. Due to recurring lung infections and difficulty in swallowing, the patient was diagnosed with PRS after birth. The patient displayed multiple organ dysfunction, including the heart and kidneys, during the treatment. Subsequent treatment with mandibular lengthening device implantation, prone ventilation, and rehabilitation training improved the patient’s swallowing and breathing difficulties. However, the patient died due to severe lung infection and multiple organ dysfunction. Thus, timely surgery, oxygen therapy, rehabilitation visits, and strengthened nursing care can improve the quality of life of such children. Hence, further understanding of Pirot syndrome and entirely realizing the collaboration between multiple disciplines is necessary for jointly developing effective treatment plans for the disease.

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“…On the other hand, in 6-month-old LBW restricted rats whose mothers received only 50% the calories during pregnancy, there was a significant reduction in kidney weight (maximal value only reached 91% of the control) and glomerular number (by 27% the control) ( 52 ). Meanwhile, a low-protein diet (reduced by 11% of the control) in pregnant rats resulted in a significant decrease in glomerular number (by 22.6% the control; at 3 months of age) and increased renal cell apoptosis of LBW F1 offspring ( 50 ).…”

Section: Intrauterine Growth Restriction and Chronic Disease Riskmentioning

confidence: 99%

“…rabbit ( 71 ) and guinea pig ( 72 )] also support the association between IUGR and reduced glomerular number and/or hypertension in the growth restricted offspring. IUGR induced by other intrauterine causes was also shown to be associated with hypertension or aberrant renal function and development ( 50 , 52 , 56 ). For example, F0 pregnant rats were fed a 50% deficit food intake diet throughout pregnancy to produce growth restricted F1 offspring ( 56 ).…”

Section: Intrauterine Growth Restriction and Chronic Disease Riskmentioning

confidence: 99%

Epigenetic Mechanisms Responsible for the Transgenerational Inheritance of Intrauterine Growth Restriction Phenotypes

2022

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A poorly functioning placenta results in impaired exchanges of oxygen, nutrition, wastes and hormones between the mother and her fetus. This can lead to restriction of fetal growth. These growth restricted babies are at increased risk of developing chronic diseases, such as type-2 diabetes, hypertension, and kidney disease, later in life. Animal studies have shown that growth restricted phenotypes are sex-dependent and can be transmitted to subsequent generations through both the paternal and maternal lineages. Altered epigenetic mechanisms, specifically changes in DNA methylation, histone modifications, and non-coding RNAs that regulate expression of genes that are important for fetal development have been shown to be associated with the transmission pattern of growth restricted phenotypes. This review will discuss the subsequent health outcomes in the offspring after growth restriction and the transmission patterns of these diseases. Evidence of altered epigenetic mechanisms in association with fetal growth restriction will also be reviewed.

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Apoptosis in the kidneys of rats that experienced intrauterine growth restriction

Abstract: The reduction in glomerular number in IUGR pups is associated with increase in renal cell apoptosis. The reduction in Bcl-2/Bax ratio may play a crucial role in renal cell apoptosis in IUGR pups.

Cited by 6 publications

References 26 publications

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats

A case of Pierre Robin sequence in a child with multiple organ dysfunction

Epigenetic Mechanisms Responsible for the Transgenerational Inheritance of Intrauterine Growth Restriction Phenotypes

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