Apoptosis in the supraspinatus tendon with stage II subacromial impingement

Tuoheti, Yilihamu; Itoi, Eiji; Pradhan, Rabindra Lal; Wakabayashi, Ikuko; Takahashi, Shuntaro; Minagawa, Hiroshi; Kobayashi, Moto; Okada, Kyoji; Shimada, Yasuhiro

doi:10.1016/j.jse.2005.01.001

Cited by 65 publications

(63 citation statements)

References 36 publications

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“…The supraspinatus tendon is usually the most affected structure due to its location just under the coracoacromial ligament 3 . Apoptosis in this tendon has already been described in subjects who were treated with subacromial decompression 4 .…”

Section: Introductionmentioning

confidence: 71%

“…It is known that SIS specifically involves the supraspinatus tendon and it has also been linked to apoptosis in this tendon 4 . Although it is beyond the scope of this study, we can suggest that the high forces produced eccentrically may have induced the beneficial tissue remodeling response on the supraspinatus tendon of the subjects leading to a better physical function status according to the DASH score.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Eccentric training for shoulder abductors improves pain, function and isokinetic performance in subjects with shoulder impingement syndrome: a case series

Camargo¹,

Ávila²,

Alburquerque‐Sendín³

et al. 2012

Rev. bras. fisioter.

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Section: Introductionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Eccentric training for shoulder abductors improves pain, function and isokinetic performance in subjects with shoulder impingement syndrome: a case series

Camargo¹,

Ávila²,

Alburquerque‐Sendín³

et al. 2012

Rev. bras. fisioter.

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“…Shoulder impingement is one of the most common causes of shoulder tendinopathy [42,43] and refers to the compression of the subacromial structures against the coracoacromial ligament during elevation of the arm [44] . Apoptosis [45] , vascular changes [26,31] , tears [46] and calcifications [47] of the supraspinatus tendon have already been described in subjects who were treated with subacromial decompression.…”

Section: Processes Of Tendinopathiesmentioning

confidence: 99%

Eccentric training as a new approach for rotator cuff tendinopathy: Review and perspectives

Camargo

Alburquerque‐Sendín

Salvini

2014

WJO

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Excessive mechanical loading is considered the major cause of rotator cuff tendinopathy. Although tendon problems are very common, they are not always easy to treat. Eccentric training has been proposed as an effective conservative treatment for the Achilles and patellar tendinopathies, but less evidence exists about its effectiveness for the rotator cuff tendinopathy. The mechanotransduction process associated with an adequate dose of mechanical load might explain the beneficial results of applying the eccentric training to the tendons. An adequate load increases healing and an inadequate (over or underuse) load can deteriorate the tendon structure. Different eccentric training protocols have been used in the few studies conducted for people with rotator cuff tendinopathy. Further, the effects of the eccentric training for rotator cuff tendinopathy were only evaluated on pain, function and strength. Future studies should assess the effects of the eccentric training also on shoulder kinematics and muscle activity. Individualization of the exercise prescription, comprehension and motivation of the patients, and the establishment of specific goals, practice and efforts should all be considered when prescribing the eccentric training.In conclusion, eccentric training should be used aiming improvement of the tendon degeneration, but more evidence is necessary to establish the adequate doseresponse and to determine long-term follow-up effects. Key words: Cellular; Mechanotransduction; Rehabilitation; Shoulder Impingement; Supraspinatus; Tendon injuries Core tip: Eccentric training can be considered a new and ambitious treatment approach for several tendinopathies. The paper establishes the basic principles for explaining the effects on the tendon of an intense mechanical load, as the eccentric training. Further, the authors bring other possible explanations of the success of this training for tendinopathies, as the individualization of the exercise programs and the motivation of the patients who reach specific goals. Negative and side effects are also identified. Finally, the main evidence afforded by original articles is commented and future research purposes are defined.Camargo PR, Alburquerque-Sendín F, Salvini TF. Eccentric training as a new approach for rotator cuff tendinopathy: Review and perspectives. World J Orthop 2014; 5(5): 634-644 Available from:

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“…Indeed, in vitro experimental studies have demonstrated that loss of homeostatic tendon strain can produce a pattern of catabolic gene expression [5,[33][34][35][36]41], apoptosis [3,17], and degenerative histological changes [5,21] similar to those seen in clinical cases of tendinopathy [1,2,5,19,24,26,28,30,31,38,39,40,45,50,54,60,61]. However, the effect of these catabolic changes on the subsequent mechanoresponsiveness of tendon cells is unknown.…”

Section: Introductionmentioning

confidence: 99%

Loss of Homeostatic Strain Alters Mechanostat “Set Point” of Tendon Cells In Vitro

Arnoczky

Lavagnino

Egerbacher

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Tendon cells respond to mechanical loads. The character (anabolic or catabolic) and sensitivity of this response is determined by the mechanostat set point of the cell, which is governed by the cytoskeleton and its interaction with the extracellular matrix. To determine if loss of cytoskeletal tension following stress deprivation decreases the mechanoresponsiveness of tendon cells, we cultured rat tail tendons under stress-deprived conditions for 48 hours and then cyclically loaded them for 24 hours at 1%, 3%, or 6% strain at 0.17 Hz. Stress deprivation upregulated MMP-13 mRNA expression and caused progressive loss of cellmatrix contact compared to fresh controls. The application of 1% strain to fresh tendons for 24 hours inhibited MMP-13 mRNA expression compared to stress-deprived tendons over the same period. However, when tendons were stressdeprived for 48 hours and then subjected to the same loading regime, the inhibition of MMP-13 mRNA expression was decreased. In stress-deprived tendons, it was necessary to increase the strain magnitude to 3% to achieve the same level of MMP-13 mRNA inhibition seen in fresh tendons exercised at 1% strain. The data suggest loss of cytoskeletal tension alters the mechanostat set point and decreases the mechanoresponsiveness of tendon cells.

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Apoptosis in the supraspinatus tendon with stage II subacromial impingement

Cited by 65 publications

References 36 publications

Eccentric training for shoulder abductors improves pain, function and isokinetic performance in subjects with shoulder impingement syndrome: a case series

Eccentric training for shoulder abductors improves pain, function and isokinetic performance in subjects with shoulder impingement syndrome: a case series

Eccentric training as a new approach for rotator cuff tendinopathy: Review and perspectives

Loss of Homeostatic Strain Alters Mechanostat “Set Point” of Tendon Cells In Vitro

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