Apoptosis induction and release of inflammatory cytokines in the oviduct of egg-laying hens experimentally infected with H9N2 avian influenza virus

Wang, Jingyu; Tang, Chao; Wang, Qiuzhen; Li, Ruiqiao; Chen, Zhanli; Han, Xueying; Wang, Jing; Xu, Xingang

doi:10.1016/j.vetmic.2015.04.005

Cited by 36 publications

(24 citation statements)

References 27 publications

(26 reference statements)

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“…It is believed that human influenza viruses including pH1N1 bind preferably to α2,6 linked sialic acids whereas AIV including H9N2 preferentially bind to α2,3 linked sialic acids (Wan and Perez, 2006). Our results are in agreement with previously published data that indicated higher expression of α2,3 linked sialic acids in all parts of the chicken oviduct compared to α2,6 linked sialic acids which were less expressed particularly in the chicken magnum (Mork et al, 2014; Wang et al, 2015). This difference in receptor abundance may subsequently influence the replication level of different IAV (Suzuki et al, 2000).…”

Section: Discussionsupporting

confidence: 94%

“…Breeder turkeys infected with H3N2 layed virus-contaminated eggs, which raised concerns regarding AIV dissemination in hatcheries (Pillai et al, 2010). In vivo infection of laying hens with H9N2 induced mild hemorrhages in the digestive and respiratory tracts associated with degeneration of epithelial cells and apoptosis in the reproductive tract (Pantin-Jackwood et al, 2012; Wang et al, 2015). In addition, immune-related genes including interleukin-2 (IL-2) and interferonβ (IFNβ) were upregulated (Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In vivo infection of laying hens with H9N2 induced mild hemorrhages in the digestive and respiratory tracts associated with degeneration of epithelial cells and apoptosis in the reproductive tract (Pantin-Jackwood et al, 2012; Wang et al, 2015). In addition, immune-related genes including interleukin-2 (IL-2) and interferonβ (IFNβ) were upregulated (Wang et al, 2015). Similar lesions in the reproductive tract of laying hens were caused by H6N2 in California (Kinde et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Authors concluded that the IBV QX strain replicates efficiently in all oviduct parts. In vivo infection studies in chickens with H9N2 indicated that all oviduct sections were susceptible to infection with H9N2 with magnum cells being the most susceptible (Wang et al, 2015). No comparable study was performed in turkeys or Pekin ducks, which are known to show different susceptibility for AIV compared to chickens.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species

Sid¹,

Hartmann²,

Winter

et al. 2017

Front. Microbiol.

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Infection of poultry with low pathogenic avian influenza viruses (LPAIV) is often associated with mild respiratory symptoms but may also lead to loss in egg production in laying birds. In vivo susceptibility of the reproductive tract for LPAIV infection was reported for turkeys and chickens, but virus-interaction with epithelial cells of the oviduct and possible stimulation of the local antiviral immune responses have not been characterized. In this study, we wanted to investigate the suitability of magnum organ cultures (MOC) as an in vitro model to study virus-host interactions. We compared the susceptibility of duck (Du), chicken (Ch), and turkey (Tu) MOC for three different influenza A viruses (IAV). Overall, the course of infection and the antiviral immune response varied between strains as well as host cell origin, but MOC gave reproducible results for all investigated parameters within each species. While pandemic (p) H1N1 and H9N2 efficiently replicated in MOC-Ch and MOC-Tu, MOC-Du were significantly less susceptible to infection as indicated by a reduced replication level for both viruses (p < 0.05). Overall, virus replication levels did not correlate with interferonα (IFNα) mRNA-expression levels in neither species. H9N2-infection led to a significant upregulation of interferonλ (IFNλ) mRNA expression in MOC of all species compared to the non-infected controls (p < 0.05), while a correlation with replication levels was only seen for MOC-Tu. pH1N1-infection induced only significant upregulation of IFNλ mRNA expression in MOC-Tu at 48 hours post infection (p < 0.05), but the expression pattern did not correlate with replication levels. Our results show that MOC are a suitable model to study IAV-interaction with the mucosal surface of the avian reproductive tract. The data suggest that the reproductive tract may play a role in the pathobiology of IAV in poultry.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species

Sid¹,

Hartmann²,

Winter

et al. 2017

Front. Microbiol.

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“…It can inhibit pathogenic bacteria and promote the growth of beneficial microorganisms [19]. Addition of 600 mg TP/kg have been observed to improve laying hens' production and egg quality [20]. Additionally, we found 600 and 1000 mg/kg TP administration can prevent laying hens from the adverse effect of vanadium to egg quality and shorten the recovery time after feeding vanadium containing diet for 35 d in previous study [21].…”

Section: Introductionmentioning

confidence: 54%

Effect of Vanadium and Tea Polyphenols on Intestinal Morphology, Microflora and Short-Chain Fatty Acid Profile of Laying Hens

Yuan

Wang

Zhang

et al. 2016

Biol Trace Elem Res

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Vanadium (V) is a trace element which can induce dysfunction of gastro-intestine and egg quality deterioration of laying hens. This study was conducted to determine the effect of tea polyphenols (TP) on intestinal morphology, microflora, and short-chain fatty acid (SCFA) profile of laying hens fed vanadium containing diets. A total of 120 Lohman laying hens (67-week-old) were randomly divided into 4 groups with 6 replicates and 5 birds each for a 35-day feeding trial. The dietary treatments were as follows: (1) control (CON), fed a basal diet; (2) vanadium treatment (V10), CON +10 mg V/kg; (3) TP treatment 1 (TP1): V10 + 600 mg TP/kg; (4) TP treatment 2 (TP2): V10 + 1000 mg TP/kg. Fed 10 mg V/kg diets to laying hens did not affect the cecum flora diversity index (H), degree of homogeneity (EH), and richness (S), but hens fed TP2 diet decreased the H, EH, and S (P < 0.05). The cecum butyrate acid concentration was lower in V10 treatment and higher in TP2 treatment (P < 0.05). Addition of 10 mg/kg V resulted in an increased (P < 0.01) duodenal cell apoptosis rate, and 1000 mg/kg TP supplementation overcame (P < 0.01) this reduction effect induced by vanadium. The results indicated that supplementation of 10 mg/kg vanadium increased duodenal cell apoptosis and reduced cecum butyrate acid content. Addition of 1000 mg/kg TP increased the SCFA production to affect cecum flora ecology and protected the duodenal cell from excess apoptosis caused by vanadium.

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Probiotic Bacillus subtilis 29,784 improved weight gain and enhanced gut health status of broilers under necrotic enteritis condition

Keerqin

Rhayat²,

Zhang

et al. 2021

Poultry Science

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Apoptosis induction and release of inflammatory cytokines in the oviduct of egg-laying hens experimentally infected with H9N2 avian influenza virus

Cited by 36 publications

References 27 publications

Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species

Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species

Effect of Vanadium and Tea Polyphenols on Intestinal Morphology, Microflora and Short-Chain Fatty Acid Profile of Laying Hens

Probiotic Bacillus subtilis 29,784 improved weight gain and enhanced gut health status of broilers under necrotic enteritis condition

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