Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot Study

Savaş, Emine Merve; Oğuz, Seda Hanife; Samadi, Afshin; İşikhan, Selen Yilmaz; Ünlütürk, Uğur; Lay, İncilay; Gürlek, Alper

doi:10.1089/met.2019.0074

Cited by 9 publications

(6 citation statements)

References 43 publications

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“…The results led the authors to suggest that the circulating monocytes of OA patients are activated prior to their entry into the synovium. Also, studies focussing on MetS patients and patients with familial hypercholesterolemia have shown that their circulating monocytes show a pro-inflammatory phenotype and increased migratory capacity, as shown by increased expression of chemokine receptors, monocyte chemotactic protein-1 (MCP-1) and activation markers compared with healthy individuals [ 59–61 ]. Interestingly, several studies have shown that this was downregulated after treatment with the LDL-lowering drugs atorvastatin and PCSK9 inhibitors [ 60–62 ], suggesting that LDL is a MetS-associated factor that mediates activation of circulating monocytes.…”

Section: Can Metabolic Activation Of Circulating Monocytes Drive a Sy...mentioning

confidence: 99%

Activation of circulating monocytes by low-density lipoprotein—a risk factor for osteoarthritis?

et al. 2022

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Synovial macrophages are key mediators of OA pathology, and skewing of macrophage phenotype in favour of an M1-like phenotype is thought to underlie the chronicity of synovial inflammation in OA. Components of the metabolic syndrome (MetS), such as dyslipidaemia, can affect macrophage phenotype and function, which could explain the link between MetS and OA development. Recently published studies have provided novel insights into the different origins and heterogeneity of synovial macrophages. Considering these findings, we propose an important role for monocyte-derived macrophages in particular, as opposed to yolk-sac derived residential macrophages, in causing a pro-inflammatory phenotype shift. We will further explain how this can start even prior to synovial infiltration; in the circulation, monocytes can be trained by metabolic factors such as low-density lipoprotein to become extra responsive to chemokines and damage-associated molecular patterns. The concept of innate immune training has been widely studied and implicated in atherosclerosis pathology, but its involvement in OA remains uncharted territory. Finally, we evaluate the implications of these insights for targeted therapy directed to macrophages and metabolic factors.

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Section: Can Metabolic Activation Of Circulating Monocytes Drive a Sy...mentioning

confidence: 99%

Activation of circulating monocytes by low-density lipoprotein—a risk factor for osteoarthritis?

et al. 2022

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“…Pro-inflammatory markers, such as tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and leptin, demonstrate a positive correlation with insulin resistance and the characteristics of MetS [23]. Moreover, deregulation of the production of monocyte chemoattractant protein-1 (MCP-1) was observed in MetS patients as a consequence of oxidative stress [24]. An increase in systemic pro-inflammatory and oxidative stress conditions has been observed in MetS patients of both genders when compared to those without MetS [25].…”

Section: Introductionmentioning

confidence: 99%

Effects of Regular Exercise on the Biochemical, Oxidative, and Inflammatory Profiles and Quality of Life in Older Spaniards with Metabolic Syndrome

Monserrat-Mesquida,

Quetglas-Llabrés,

Bouzas

et al. 2024

Antioxidants

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Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and inflammatory profiles, as well as the quality of life of older adults diagnosed with metabolic syndrome. Participants (aged 55–70 years; living in the Balearic Islands, Spain) were divided into two groups (n = 50 each) according to the degree of physical activity measured by metabolic equivalents of task (METs). Anthropometric parameters, blood pressure, biochemical and hematological parameters, and inflammatory biomarkers were measured. Beck Depression Inventory and adherence to the Mediterranean diet questionnaires, as well as the Dietary Inflammatory Index, chair test, health-related quality of life (HRQoL), and Rapid Assessment of Physical Activity, were also determined. The characterization of the patients was similar in both groups, showing a homogeneous sample. The group with the highest METs experienced a decrease in depression and an increase in the intensity of physical activity. Adherence to the Mediterranean diet and HRQoL physical dimensions increased in participants with the highest METs, also showing a decrease in glycemia and glycosylated hemoglobin values. Inflammatory biomarkers, including tumor necrosis factor alpha, interleukin-6, interleukin-1β, and osteoprotegerin, decreased in patients practicing more physical activity. High levels of physical activity are related to a healthier lifestyle, characterized by high adherence to the Mediterranean diet, decreased depressive behavior, oxidative stress, and inflammatory status in older people with metabolic syndrome.

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“…This innate immaturity is characterized by altered cytokines production and decreased function of antigen-presenting cells 9 , 10 . Blood culture remains the gold standard for the diagnosis of neonatal sepsis, but beside delayed results and low sensitivity, cost and access to those techniques in RLS limit its use 11 , 12 . Other tests routinely used for the diagnosis of neonatal sepsis, such as C-reactive protein (CRP) and blood count (total and differential white blood cell counts, absolute and immature neutrophil counts, and the ratio of immature to total neutrophils), are not unanimously recognized as good biomarkers of neonatal sepsis, respectively having a low specificity and lack of sensitiveness 13 – 16 .…”

Section: Introductionmentioning

confidence: 99%

Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa

Ezinmègnon

Mommert

Bartolo³

et al. 2022

Sci Rep

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Few biomarkers for sepsis diagnosis are commonly used in neonatal sepsis. While the role of host response is increasingly recognized in sepsis pathogenesis and prognosis, there is a need for evaluating new biomarkers targeting host response in regions where sepsis burden is high and medico-economic resources are scarce. The objective of the study is to evaluate diagnostic and prognostic accuracy of biomarkers of neonatal sepsis in Sub Saharan Africa. This prospective multicentre study included newborn infants delivered in the Abomey-Calavi region in South Benin and their follow-up from birth to 3 months of age. Accuracy of transcriptional (CD74, CX3CR1), proteic (PCT, IL-6, IL-10, IP-10) biomarkers and clinical characteristics to diagnose and prognose neonatal sepsis were measured. At delivery, cord blood from all consecutive newborns were sampled and analysed, and infants were followed for a 12 weeks’ period. Five hundred and eighty-one newborns were enrolled. One hundred and seventy-two newborns developed neonatal sepsis (29.6%) and death occurred in forty-nine infants (8.4%). Although PCT, IL-6 and IP-10 levels were independently associated with sepsis diagnosis, diagnostic accuracy of clinical variables combinations was similar to combinations with biomarkers and superior to biomarkers alone. Nonetheless, CD74, being the only biomarkers independently associated with mortality, showed elevated prognosis accuracy (AUC > 0.9) either alone or in combination with other biomarkers (eg. CD74/IP-10) or clinical criterion (eg. Apgar 1, birth weight). These results suggest that cord blood PCT had a low accuracy for diagnosing early onset neonatal sepsis in Sub Saharan African neonates, while association of clinical criterion showed to be more accurate than any biomarkers taken independently. At birth, CD74, either associated with IP-10 or clinical criterion, had the best accuracy in prognosing sepsis mortality.Trial registration Clinicaltrial.gov registration number: NCT03780712. Registered 19 December 2018. Retrospectively registered.

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Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot Study

Cited by 9 publications

References 43 publications

Activation of circulating monocytes by low-density lipoprotein—a risk factor for osteoarthritis?

Activation of circulating monocytes by low-density lipoprotein—a risk factor for osteoarthritis?

Effects of Regular Exercise on the Biochemical, Oxidative, and Inflammatory Profiles and Quality of Life in Older Spaniards with Metabolic Syndrome

Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa

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