2020
DOI: 10.12737/1024-6177-2020-65-4-36-42
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Apoptosis of Lymphocytes and Polymorphisms of Apoptosis Regulation Genes in Individuals Exposed to Chronic Radiation Exposure

Abstract: Purpose: Study the apoptotic death of peripheral blood lymphocytes in long-term period in persons exposed to chronic radiation exposure, and analysis of association of the polymorphic regions rs4645878, rs2279115, rs28362491, rs664677, rs1042522, rs1801270, rs2279744 of the BAX, BCL2, NFkB, ATM, TP53, CDKN1A, MDM2 genes with apoptotic lymphocytes frequency in residents of the coastal villages of the Techa River. Material and methods: The study of apoptosis and genotyping was conducted in 390 persons expo… Show more

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“…In studies conducted earlier in chronically exposed residents of the Techa riverside settlements, changes in the intensity of apoptotic death of the peripheral blood lymphocytes were registered in the longterm period (Blinova et al, 2020a). Moreover, changes in the transcriptional activity of apoptotic genes accompanied by a decrease in the relative mRNA content of the BCL-2 gene and increase in the relative content of mRNA of the BAX gene were demonstrated in exposed people 60 years after the onset of chronic radiation exposure (Nikiforov et al, 2020).…”
Section: Introductionmentioning
confidence: 91%
“…In studies conducted earlier in chronically exposed residents of the Techa riverside settlements, changes in the intensity of apoptotic death of the peripheral blood lymphocytes were registered in the longterm period (Blinova et al, 2020a). Moreover, changes in the transcriptional activity of apoptotic genes accompanied by a decrease in the relative mRNA content of the BCL-2 gene and increase in the relative content of mRNA of the BAX gene were demonstrated in exposed people 60 years after the onset of chronic radiation exposure (Nikiforov et al, 2020).…”
Section: Introductionmentioning
confidence: 91%