Apoptosis, Pyroptosis, and Necroptosis—Oh My! The Many Ways a Cell Can Die

Ketelut-Carneiro, Natália; Fitzgerald, Katherine A.

doi:10.1016/j.jmb.2021.167378

Cited by 209 publications

(145 citation statements)

References 278 publications

Supporting

Mentioning

144

Contrasting

Unclassified

Order By: Relevance

“…That is, the cell commits three fates when TNF engages its receptor and forms Complex I, which consists of TNFR1-associated death domain protein (TRADD), TNFR-associated factors (TRAF), RIPK1, the cellular inhibitor of apoptosis protein 1 (cIAP1), and the cellular inhibitor of apoptosis protein 2 (cIAP2) ( 55 ). If RIPK1 is ubiquitinated, cell death is aborted; if caspase-8 activity is inhibited, necroptosis occurs; otherwise, the cells undergo apoptosis ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis

et al. 2022

View full text Add to dashboard Cite

BackgroundNecroptosis, a recently discovered programmed cell death, has been pathologically linked to various diseases and is thus a promising target for treating diseases. However, a comprehensive and objective report on the current status of entire necroptosis research is lacking. Therefore, this study aims to conduct a bibliometric analysis to quantify and identify the status quo and trending issues of necroptosis research in the last decade.MethodsArticles were acquired from the Web of Science Core Collection database. We used two bibliometric tools (CiteSpace and VOSviewer) to quantify and identify the individual impact and cooperation information by analyzing annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Afterwards, we identified the trending research areas of necroptosis by analyzing the co-occurrence and burst of keywords and co-cited references.ResultsFrom 2012 to 2021, a total of 3,111 research articles on necroptosis were published in 786 academic journals by 19,687 authors in 885 institutions from 82 countries/regions. The majority of publications were from China and the United States, of which the United States maintained the dominant position in necroptosis research; meanwhile, the Chinese Academy of Sciences and Ghent University were the most active institutions. Peter Vandenabeele published the most papers, while Alexei Degterev had the most co-citations. Cell Death & Disease published the most papers on necroptosis, while Cell was the top 1 co-cited journal, and the major area of these publications was molecular, biology, and immunology. High-frequency keywords mainly included those that are molecularly related (MLKL, TNF-alpha, NF-κB, RIPK3, RIPK1), pathological process related (cell-death, apoptosis, necroptosis, necrosis, inflammation), and disease related (cancer, ischemia/reperfusion injury, infection, carcinoma, Alzheimer’s disease).ConclusionNecroptosis research had a stable stepwise growth in the past decade. Current necroptosis studies focused on its cross-talk with other types of cell death, potential applications in disease treatment, and further mechanisms. Among them, the synergy with ferroptosis, further RIPK1/RIPK3/MLKL studies, its association with inflammation and oxidative stress and translational applications, and the therapeutic potential to treat cancer and neurodegenerative diseases are the trending research area. These might provide ideas for further research in the necroptosis field.

show abstract

Section: Discussionmentioning

confidence: 99%

Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These two pathways have been extensively reviewed elsewhere [12]. Briefly, apoptosis is often divided into an intrinsic and extrinsic pathway.…”

Section: Overview Of Programmed Cell Deathmentioning

confidence: 99%

“…Despite the differences in the apoptotic and necroptotic molecular pathways, in practical application, no single test unequivocally distinguishes the two. Instead, both morphologic and biochemical data must be integrated to discriminate these two pathways [9,10,12].…”

Section: Overview Of Programmed Cell Deathmentioning

confidence: 99%

Cell Death in AMD: The Rationale for Targeting Fas

Zacks

Kocab

Choi

et al. 2022

JCM

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world. While great advances have been made in the treatment of the neovascular (“wet”) form of the disease, there is still a significant need for therapies that prevent the vision loss associated with the advanced forms of dry, atrophic AMD. In this atrophic form, retinal pigment epithelial (RPE) and photoreceptor cell death is the ultimate cause of vision loss. In this review, we summarize the cell death pathways and their relation to RPE and retinal cell death in AMD. We review the data that support targeting programmed cell death through inhibition of the Fas receptor as a novel approach to preserve these structures and that this effect results from inhibiting both canonical death pathway activation and reducing the associated inflammatory response. These data lay the groundwork for current clinical strategies targeting the Fas pathway in this devastating disease.

show abstract

“…While apoptosis is clearly the most well studied form of cell death, in the last two decades additional forms of cell death, including cell necrosis, have been molecularly characterized [ 150 ]. The understanding that behind the term of “cell necrosis” coexist several genetically controlled forms of cell death, raised important questions on how these different forms of regulated cell death integrate for the elimination of cells in different cellular and organismal contexts [ 12 , 133 , 151 ]. For example, it is intriguing that apoptosis is the main cell death mechanism for the elimination of excess cells during development, while other regulated cell death pathways are used during neurodegeneration or the death of cancer cells that are resistant to apoptosis.…”

Section: Team Workmentioning

confidence: 99%

“…The dogma that apoptosis is the only form of regulated cell death involved in animal development and pathologies was challenged by the understanding that necrotic cell death is not only an accidental process but can be genetically controlled. This led to the identification and characterization of different regulated necrosis pathways including necroptosis, ferroptosis, pyroptosis and parthanatos [ 12 , 13 ]. It is now generally accepted that regulated necrosis is also involved in the control of cell homeostasis during differentiation, such as for p53-dependent elimination of excess germ cells during spermatogenesis in both vertebrates and invertebrates ( Mollereau team).…”

Section: General Introductionmentioning

confidence: 99%

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

et al. 2022

View full text Add to dashboard Cite

Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although many aspects of regulated cell death still remain to be elucidated in specific cell subtypes and disease conditions, many predicted that research into cell death was inexorably reaching a plateau. However, this was not the case since the last decade saw a multitude of cell death modalities being described, while harnessing their therapeutic potential reached clinical use in certain cases. In line with keeping research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN). The research conducted by FCDRN is at the leading edge of emerging topics such as non-apoptotic functions of apoptotic effectors, paracrine effects of cell death, novel canonical and non-canonical mechanisms to induce apoptosis in cell death-resistant cancer cells or regulated forms of necrosis and the associated immunogenic response. Collectively, these various lines of research all emerged from the study of apoptosis and in the next few years will increase the mechanistic knowledge into regulated cell death and how to harness it for therapy.

show abstract

Apoptosis, Pyroptosis, and Necroptosis—Oh My! The Many Ways a Cell Can Die

Cited by 209 publications

References 278 publications

Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis

Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis

Cell Death in AMD: The Rationale for Targeting Fas

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Contact Info

Product

Resources

About