Apoptosis regulator BAX of chinese tree shrew (Tupaia Belangeri Chinensis): Molecular Modelling and Structural Characterization

Panda, Subhamay; Prasad, Dipak

doi:10.22376/ijpbs.2016.7.4.b747-752

Cited by 2 publications

(2 citation statements)

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“…For the translocation of BAX to mitochondria, a mitochondrial addressing signal of N-terminal Hα1 is believed to be necessary [29]. Recent bioinformatical research methods were very helpful for the discovery process of new biologically and biomedically important protein molecules [30][31][32][33][34][35][36][37][38][39]. Therefore, varied structural forms of BAX molecules in the different organisms (e.g., Chinese liver fluke) must be identified for bio-medical interventions.…”

Section: Resultsmentioning

confidence: 99%

The Biophysical Characteristics and Structural Exploration of Programmed Cell Death Regulator B-Cell Lymphoma 2-Associated X Protein of Chinese Liver Fluke (Clonorchis Sinensis)

Panda¹,

Prasad²,

Bag³

2017

Asian J Pharm Clin Res

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Objective: The balance between deaths and cellular life is regulated by B-cell lymphoma 2 (BCL-2)-associated X protein (BAX) an important proapoptotic components of BCL-2 family. With this initial point, the aim of this study was to determine a comparative composite based structure of BAX of Chinese liver fluke and different structural analysis. Methods:Protein amino acid of BAX of Chinese liver fluke mined from National Centre for Biotechnology Information (http://ncbi.nlm.nih.gov). Molecular model of BAX of Chinese liver fluke protein was generated by the comparative composite modeling tool Iterative Threading ASSEmbly Refinement suite. Afterward, I-TASSER generated molecular model was subjected to further structural improvements by energy minimization step. Distribution of negatively and positively charged amino acid over molecular modeled structure, distribution of secondary structural elements, and hydrophobicity molecular surface analysis was performed with the help of bioinformatical tools.Results: Analysis of Ramachandran plot created by PROCHECK tool is a consensus standard for validation purpose of protein structural modeling. Altogether 97.8% of the residues were detected in allowed and favored regions, which in turn validate the quality of generated protein structural model. Total negatively and positively charged residues within the BAX of Chinese liver fluke were 23 and 20, respectively. Chimera package-guided hydrophobicity molecular surface analysis illustrates that molecule specific hydrophobicity surface is exclusive to BAX protein molecule. Conclusion:Within the scope of this scientific investigation, we have successfully utilized molecular modeling approach to suggest the first molecular three-dimensional model structure of BAX of Chinese liver fluke. The synchronous balance between cellular deaths and cellular life is keeping up by BAX, an important pro-apoptotic family member of BCL-2 family. Consequently, it would be an exciting approach to resolve its structural characterization and molecular structure to propose mode of mechanism action.

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Section: Resultsmentioning

confidence: 99%

The Biophysical Characteristics and Structural Exploration of Programmed Cell Death Regulator B-Cell Lymphoma 2-Associated X Protein of Chinese Liver Fluke (Clonorchis Sinensis)

Panda¹,

Prasad²,

Bag³

2017

Asian J Pharm Clin Res

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“…While planning, we have to take into consideration the strategies and experiences of other countries to circumvent costly errors and to revise the work in generating and managing the national health information system. Fortunately, recent state of the art informatics research practices makes it accomplishable to address tangled research problems in biomedical sciences [29][30][31][32][33][34][35][36].…”

Section: Health Information System: An Overviewmentioning

confidence: 99%

The Role of Health Information System in Maternal and Child Healthcare Services

Chowdhury¹,

Kumari

Panda³

2017

Asian J Pharm Clin Res

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Health information system deals with any system that helps in capturing, storing, transmitting, and managing health-related information of an individual or to demonstrate the activities or organizations working within health-care sector. In the developing countries, maternal and child health is gaining concern due to increasing cases of morbidity and mortality. The disparities among the maternal, infant, and child health are a growing concern in India and are governed by various determinants such as socioeconomic status, literacy, quality of health care, discrimination, and biological and genetic factors. Accurate and reliable health information and data are the basis for decision-making across the health-care sector and are crucial for the development and implementation of health system policy by the policy-makers. Strict monitoring and evaluation of the present program design and its implementation is required at the microlevel to effectively utilize the resources for the improvement of maternal and child health. Our present article focuses on evaluating the coverage gap at the different levels for the provision of health-care facilities to maternal, neonatal, and child health, immunization, and treatment of poor children. Big data plays a major role in providing sound and reliable health-related information and also help in managing and recording structured and unstructured data. More concrete plans are required further to reduce the inequalities in health-care interventions for providing better maternal and child health-care services in our nation.

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Apoptosis regulator BAX of chinese tree shrew (Tupaia Belangeri Chinensis): Molecular Modelling and Structural Characterization

Cited by 2 publications

References 33 publications

The Biophysical Characteristics and Structural Exploration of Programmed Cell Death Regulator B-Cell Lymphoma 2-Associated X Protein of Chinese Liver Fluke (Clonorchis Sinensis)

The Biophysical Characteristics and Structural Exploration of Programmed Cell Death Regulator B-Cell Lymphoma 2-Associated X Protein of Chinese Liver Fluke (Clonorchis Sinensis)

The Role of Health Information System in Maternal and Child Healthcare Services

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