Apoptosis-related microRNA-145-5p enhances the effects of pheophorbide a-based photodynamic therapy in oral cancer

Moon, Sook; Kim, Do Kyeong; Kim, Jin

doi:10.18632/oncotarget.17059

Cited by 30 publications

(25 citation statements)

References 29 publications

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“…MiR-32-5p was significantly decreased in fatty acids-treated human colorectal adenocarcinoma cells accompanied by a decrease in BCL-2 and BCL2L11 expression [ 24 ]. In addition, photodynamic therapy strongly down-regulated the expression miR-32-5p in oral cancer cells, but its roles in the therapeutic effect of photodynamic therapy are unknown [ 25 ]. Our results firstly identified that miR-32-5p was increased in PC tissues and cells, and was associated with the migration and invasion of PC cells.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis

et al. 2017

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BackgroundLong non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is a well-known tumor suppressor in the pathogenesis of a variety of human cancers. The precise role of GAS5 in pancreatic cancer (PC) progression is currently unknown, so the aim of this study was to explore the functional participation of GAS5 in PC metastasis.MethodsThe expression changes of GAS5, miR-32-5p and PTEN in human PC specimens and cell lines were compared by means of molecular biology methods. Transfection of the recombinant plasmid was applied to modulate the expression levels of the target genes. RIP and RNA pull-down assays were designed to investigate the interaction between GAS5 and miR-32-5p. The effect of GAS5 and miR-32-5p on PC progression was assessed with cell proliferation, migration, invasion and apoptosis in vitro.ResultsGAS5 and PTEN protein were decreased in human PC tissues and cells, but miR-32-5p was increased. GAS5 induction greatly inhibited the proliferation, migration and invasion of PC cells PANC-1 and BxPC-3 in vitro and simultaneously induced cell apoptosis. Moreover, GAS5 positively regulated the expression of PTEN through miR-32-5p. Furthermore, GAS5 suppressed the proliferation, migration and invasion of PC cells through regulating miR-32-5p/PTEN axis. Additionally, this finding was further supported by the results of in vivo experiments.ConclusionGAS5 could positively regulate PTEN-induced tumor-suppressor pathway via miR-32-5p, thereby suppressing PC metastasis.Electronic supplementary materialThe online version of this article (10.1186/s13578-017-0192-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis

et al. 2017

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“…Pheophorbide A, a product derived from the degradation of chlorophyll, has been used in the clinic as an imaging and anticancer agent [54,55,56,57,58,59]. Consequently, the ability of Pheophorbide A to treat RA has been evaluated [60].…”

Section: Photosensitizers Used To Treat Rheumatoid Arthritismentioning

confidence: 99%

Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis

Gallardo-Villagrán

Léger

Liagre

et al. 2019

IJMS

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Photodynamic Therapy (PDT) has become one of the most promising treatment against autoimmune diseases, such as rheumatoid arthritis (RA), as well as in the treatment of different types of cancer, since it is a non-invasive method and easy to carry out. The three main ingredients of PDT are light irradiation, oxygen, and a photosensitizer (PS). Light irradiation depends on the type of molecule or compound to be used as a PS. The concentration of O2 fluctuates according to the medium where the target tissue is located and over time, although it is known that it is possible to provide oxygenated species to the treated area through the PS itself. Finally, each PS has its own characteristics, the efficacy of which depends on multiple factors, such as solubility, administration technique, retention time, stability, excitation wavelength, biocompatibility, and clearance, among others. Therefore, it is essential to have a thorough knowledge of the disease to select the best PS for a specific target, such as RA. In this review we will present the PSs used in the last three decades to treat RA under PDT protocol, as well as insights on the relevant strategies.

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“…miRNAs have been reported as oncogenes or tumor suppressor genes, which regulate tumorigenesis and metastasis through targeting various genes that are abnormally expressed in cancer cells (11). As a tumor suppressive miRNA, miR-145 has been reported to be decreased in numerous types of human cancer, including pancreatic cancer (12), prostate cancer (13), cervical cancer (14), gastric cancer (15), oral cancer (16), colorectal cancer (17), breast cancer (18), bladder cancer (19) and melanoma (20). These previous studies have indicated that miR-145 may suppress the growth, migration and invasion of cancer cells, and inhibit tumorigenesis by targeting various genes that are abnormally expressed in tumors.…”

Section: Introductionmentioning

confidence: 99%

miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1

Chen

You

et al. 2018

Int J Oncol

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Non-small cell lung cancer (NSCLC) is a leading cause of cancer-associated mortality worldwide. Right open reading frame kinase 2 (RIOK2) and nin one binding protein (NOB1) are important accessory factors in ribosome assembly. In our previous study, RIOK2 and NOB1 were revealed to be highly expressed in NSCLC, and were associated with the clinicopathological characteristics of patients with NSCLC, i.e. TNM clinical stage, lymph node metastasis and differentiation. In addition, RIOK2 expression was correlated with NOB1. To further explore the mechanism and the RIOK2 and NOB1 signaling pathway, microRNA (miR) regulation was analyzed. The tumor suppressor miR‑145 has been reported to be lowly expressed in numerous types of human cancer; in the present study, the expression levels of miR‑145 were decreased in patients with NSCLC. Furthermore, RIOK2 and NOB1 were predicted to be the direct targets of miR‑145 using bioinformatics software; this was further validated using a dual luciferase reporter assay. In addition, the protein expression levels of RIOK2 and NOB1 were inhibited in response to miR‑145 overexpression, thus resulting in the suppression of cell viability, migration and invasion. These results suggested that RIOK2 and NOB1 may be potential targets in the treatment of NSCLC, and miR‑145 may be considered a therapeutic inhibitor of both genes.

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Apoptosis-related microRNA-145-5p enhances the effects of pheophorbide a-based photodynamic therapy in oral cancer

Cited by 30 publications

References 29 publications

Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis

Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis

Photosensitizers Used in the Photodynamic Therapy of Rheumatoid Arthritis

miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1

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