2023
DOI: 10.1002/cbf.3866
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Apoptotic activity of genipin in human oral squamous cell carcinoma in vitro by regulating STAT3 signaling

Dong‐Guk Park,
Bohwan Jin,
Won W. Lee
et al.

Abstract: Genipin, a natural compound derived from the fruit of Gardenia jasminoides Ellis, was reported to have activity against various cancer types. In this study, we determined the underlying mechanism for genipin‐induced cell death in human oral squamous cell carcinoma (OSCC). The growth‐inhibitory effects of genipin in human OSCC cells was examined by the Cell Counting Kit‐8 and soft agar assays. The effects of genipin on apoptosis were assessed by nuclear morphological changes by 4′,6‐diamidino‐2‐phenylindole sta… Show more

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