Apoptotic activity of the marine diatom<i>Cocconeis scutellum</i>and eicosapentaenoic acid in BT20 cells

Nappo, M.; Berkov, Strahil; Massucco, Carlotta; Maria, Valentina Di; Codina, Carles; Ávila, Conxita; Messina, Patrizia; Zupo, Valerio; Zupo, Simona

doi:10.3109/13880209.2011.611811

Cited by 35 publications

(28 citation statements)

References 19 publications

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“…Several studies have reported biological activities of fatty acids from various microalgal species, like anti-bacterial [105,106,107] andanti-cancer activities [108]. Further characterization of the lipid content in the total jellyfish extract (TE) and its fractions is in progress.…”

Section: Resultsmentioning

confidence: 99%

Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures

et al. 2013

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On a global scale, jellyfish populations in coastal marine ecosystems exhibit increasing trends of abundance. High-density outbreaks may directly or indirectly affect human economical and recreational activities, as well as public health. As the interest in biology of marine jellyfish grows, a number of jellyfish metabolites with healthy potential, such as anticancer or antioxidant activities, is increasingly reported. In this study, the Mediterranean “fried egg jellyfish” Cotylorhiza tuberculata (Macri, 1778) has been targeted in the search forputative valuable bioactive compounds. A medusa extract was obtained, fractionated, characterized by HPLC, GC-MS and SDS-PAGE and assayed for its biological activity on breast cancer cells (MCF-7) and human epidermal keratinocytes (HEKa). The composition of the jellyfish extract included photosynthetic pigments, valuable ω-3 and ω-6 fatty acids, and polypeptides derived either from jellyfish tissues and their algal symbionts. Extract fractions showed antioxidant activity and the ability to affect cell viability and intercellular communication mediated by gap junctions (GJIC) differentially in MCF-7and HEKa cells. A significantly higher cytotoxicity and GJIC enhancement in MCF-7 compared to HEKa cells was recorded. A putative action mechanism for the anticancer bioactivity through the modulation of GJIC has been hypothesized and its nutraceutical and pharmaceutical potential was discussed.

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Section: Resultsmentioning

confidence: 99%

Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures

et al. 2013

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“…Microalgae have a great potential for the production of bioactive molecules of pharmaceutical interest [1,2,3,4,5]. Particularly, microalgal pigments protect normal cells from genetic damages and exert antiproliferative, cytotoxic and pro-apoptotic activities in cancer cells, suggesting their possible use for cancer prevention or chemiotherapy [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

et al. 2013

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The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 µg·mL−1. Flash chromatography of the Cp ethanol extract, devoid of c-phycocyanin and allophycocyanin, enabled the collection of eight fractions, four of which strongly inhibited cancer cells growth at 100 µg·mL−1. Particularly, two fractions inhibited more than 90% of the melanoma cells growth, one inducing apoptosis in the three cancer cells lines. The detailed analysis of Cp pigment composition resulted in the discrimination of 17 molecules, ten of which were unequivocally identified by high resolution mass spectrometry. Pheophorbide a, β-cryptoxanthin and zeaxanthin were the three main pigments or derivatives responsible for the strong cytotoxicity of Cp fractions in cancer cells. These data point to Cyanophora paradoxa as a new microalgal source to purify potent anticancer pigments, and demonstrate for the first time the strong antiproliferative activity of zeaxanthin and β-cryptoxanthin in melanoma cells.

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“…In Table 2, we report the microalgae for which the most abundant PUFAs produced were studied. Several biological functions have been associated to DHA and EPA, such as a wide range of beneficial cardiovascular effects [82], antimicrobial activities [83], anti-inflammatory modulation [84], antioxidant properties [85], beneficial effects on respiratory diseases [86,87], antitumoral activity [88], and inflammation attenuation in adipose tissues [89]. Different authors highlighted the immune-stimulatory properties of PUFA [90,91], as well as their anti-inflammatory properties [92].…”

Section: Polyunsaturated Fatty Acids (Pufas)mentioning

confidence: 99%

Microalgae with Immunomodulatory Activities

2019

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Microalgae are photosynthetic microorganisms adapted to live in very different environments and showing an enormous biochemical and genetic diversity, thus representing an excellent source of new natural products with possible applications in several biotechnological sectors. Microalgae-derived compounds have shown several properties, such as anticancer, antimicrobial, anti-inflammatory, and immunomodulatory. In the last decade, compounds stimulating the immune system, both innate immune response and adaptive immune response, have been used to prevent and fight various pathologies, including cancer (cancer immunotherapy). In this review we report the microalgae that have been shown to possess immunomodulatory properties, the cells and the cellular mediators involved in the mechanisms of action and the experimental models used to test immunostimulatory activities. We also report information on fractions or pure compounds from microalgae identified as having immunostimulatory activity. Given the increasing interest in microalgae as new eco-friendly source of bioactive compounds, we also discuss their possible role as source of new classes of promising drugs to treat human pathologies.

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Apoptotic activity of the marine diatomCocconeis scutellumand eicosapentaenoic acid in BT20 cells

Abstract: (2012) Apoptotic activity of the marine diatom Cocconeisscutellum and eicosapentaenoic acid in BT20 cells, Pharmaceutical Biology, 50:4, 529-535,

Cited by 35 publications

References 19 publications

Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures

Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction Intercellular Communication in Human Cell Cultures

Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells

Microalgae with Immunomodulatory Activities

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