Apoptotic and Cytotoxic Effect of Origanum Minutiflorum on Nb2a Neuroblastoma Cells

Sarı, İsmail; Dönmez, Gonca; Özkan, Oktay; Aydemir, Işıl; Özbey, Caner; Tuğlu, Mehmet İbrahim

doi:10.33483/jfpau.707277

Cited by 1 publication

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“…Recently few studies have investigated the cytotoxic effect of Origanum species such as O. majorana L. extract on human breast cancer cell line (MCF-7) (Jssim and Abdul-Halim, 2020) or oregano essential oil from Origanum minutiflorum O. Schwarz & P.H. Davis on NB2a neuroblastoma cells (Sari et al, 2020). The antimicrobial effect of O. onites against P. aeruginosa, E. coli, and S. aureus strains were investigated and it was found to have a strong antimicrobial effect (Andoğan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

In vitro physiological effects of Origanum onites L. (Lamiaceae) essential oil treatment on human origin cell lines

Gundogan¹,

Nath²

2021

Turk J Bot

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Origanum onites L. belongs to the Lamiaceae family which is commonly used for symptomatic treatment of the diseases of the gastrointestinal, endocrine, and respiratory systems in Turkish ethnobotanical studies and public. In this study our aim was to investigate the physiological effects of O. onites essential oil (OE) on A549 human lung cancer, MIA PaCa human pancreas cancer and HUVEC human endothelial cell lines. Our findings showed that O. onites OE treatment at all concentrations (4.79-191.6 µg/mL, 24 h) can inhibit cell proliferation and induce apoptosis in A549 and MIA PaCa cell lines (P < 0.0001). Although ≤19.16 µg/mL OE treatment for 24 h did not inhibit cell proliferation in the HUVEC cell lines, higher concentrations of OE (≥38.32 µg/mL) significantly inhibited cell proliferation. Apoptotic cell counts were significantly (P < 0.0001) higher in all cell lines at both incubation times (

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Section: Introductionmentioning

confidence: 99%