Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift

Kraynak, Chelsea A.; Huang, Wenbai; Bender, Elizabeth C.; Wang, Jieliang; Hanafy, Mahmoud S.; Cui, Zhengrong; Suggs, Laura J.

doi:10.1016/j.ijpharm.2022.121634

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…Drug delivery systems with immunomodulatory capabilities have been designed to target specific pathways and immune cell populations relevant to these diseases. For instance, in RA, NPs containing anti-inflammatory cytokines, such as IL-10, have demonstrated efficacy in reducing joint inflammation [ 13 , 45 , 72 ].…”

Section: Nanomaterial-based Approaches For Treating Autoimmune Diseas...mentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

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Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, and inorganic NPs, and discuss their detailed design intricacies, mechanisms, and applications, including the current regulatory issues. This type of nanomaterial design for targeting specific immune cells or tissues and controlling release kinetics could push current technological frontiers and provide new and innovative solutions for immune-related disorders and diseases without off-target effects. These materials enable targeted interactions with immune cells, thereby enhancing the effectiveness of checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Moreover, they allow for fine-tuning of immune responses while minimizing side effects. At the intersection of nanotechnology and immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy and reshape disease management. By prioritizing safety, customization, and compliance with regulatory standards, these systems can make significant contributions to precision medicine, thereby significantly impacting the healthcare landscape.

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Section: Nanomaterial-based Approaches For Treating Autoimmune Diseas...mentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…They can also trigger T-cells differentiation by an exhibition of MHC and costimulatory molecules [97]. Neutrophils are also known to contribute to clearing inflammation and start the production of anti-inflammatory substances among other myeloid cells [98,99].…”

Section: Neutrophilsmentioning

confidence: 99%

Classic and Current Opinions in Human Organ and Tissue Transplantation

Oli¹,

Rowaiye²,

Adejumo³

et al. 2022

Cureus

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Graft tolerance is a pathophysiological condition heavily reliant on the dynamic interaction of the innate and adaptive immune systems. Genetic polymorphism determines immune responses to tissue/organ transplantation, and intricate humoral and cell-mediated mechanisms control these responses. In transplantation, the clinician's goal is to achieve a delicate equilibrium between the allogeneic immune response, undesired effects of the immunosuppressive drugs, and the existing morbidities that are potentially life-threatening. Transplant immunopathology involves sensitization, effector, and apoptosis phases which recruit and engages immunological cells like natural killer cells, lymphocytes, neutrophils, and monocytes. Similarly, these cells are involved in the transfer of normal or genetically engineered T cells. Advances in tissue transplantation would involve a profound knowledge of the molecular mechanisms that underpin the respective immunopathology involved and the design of precision medicines that are safe and effective.

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“…Previously, we have designed an apoptotic body mimicking nanoparticle to reduce pro-inflammatory polarization of macrophages through presentation of PS-containing cell membranes on the surface of polymeric nanoparticles. , These nanoparticles reduced inflammation, but we are now interested in how their underlying physical characteristics could be tuned to further improve their uptake. These findings could be used in combination with anti-inflammatory drugs to provide the best treatment for chronic inflammatory conditions through targeted delivery to macrophages.…”

Section: Introductionmentioning

confidence: 99%

Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake

Bender,

Sircar,

Taubenfeld

et al. 2024

ACS Biomater. Sci. Eng.

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Macrophage uptake of nanoparticles is highly dependent on the physicochemical characteristics of those nanoparticles. Here, we have created a collection of lipid-polymer nanoparticles (LPNPs) varying in size, stiffness, and lipid makeup to determine the effects of these factors on uptake in murine bone marrow-derived macrophages. The LPNPs varied in diameter from 232 to 812 nm, in storage modulus from 21.2 to 287 kPa, and in phosphatidylserine content from 0 to 20%. Stiff, large nanoparticles with a coating containing phosphatidylserine were taken up by macrophages to a much higher degree than any other formulation (between 9.3× and 166× higher than other LPNPs). LPNPs with phosphatidylserine were taken up most by M2-polarized macrophages, while those without were taken up most by M1-polarized macrophages. Differences in total LPNP uptake were not dependent on endocytosis pathway(s) other than phagocytosis. This work acts as a basis for understanding how the interactions between nanoparticle physicochemical characteristics may act synergistically to facilitate particle uptake.

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Apoptotic body-inspired nanoparticles target macrophages at sites of inflammation to support an anti-inflammatory phenotype shift

Cited by 10 publications

References 40 publications

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Classic and Current Opinions in Human Organ and Tissue Transplantation

Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake

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