“…Blue light, as a visible light with a wavelength range of 400–500 nm, has been clinically applied successfully comprising neonatal jaundice, psoriasis (Pv), atopic dermatitis (AD), eczema, acne, and other inflammatory skin conditions, although the number of available clinical studies evaluating the efficacy of blue light treatment is still limited ( 103 , 136 ). Furthermore, recent studies have demonstrated that blue light irradiation inhibits the proliferation of multiple types of cancer cells in vitro and in vivo , including colon cancer cells ( 14 , 144 , 145 ), malignant glioma cells ( 12 ), melanoma cells ( 10 , 146 , 147 ), B-cell lymphoma cells ( 13 ), fibrosarcoma cells ( 14 ), pancreatic cancer cells ( 15 ), cutaneous squamous cell carcinoma cells (CSCC), epidermoid carcinoma cells ( 148 , 149 ), leukemia cells (Kasumi-1) ( 150 ), bladder cancer cells ( 151 ), colorectal cancer cells ( 152 , 153 ), breast cancer cells ( 91 ), and human OS cells ( 95 , 98 ). Here, we have briefly summarized the relevant research of blue light PBMT in the field of cancer treatment ( Table 1 ).…”