Aporphine Alkaloids of Selected Species of<i>Nectandra</i>and<i>Ocotea</i>

López, José A.; Barillas, Wagner; Gómez-Laurito, Jorge; Lin, Fu-Tyan; Al‐Rehaily, Adnan J.; Sharaf, Maged H. M.; Schiff, Paul L.

doi:10.1055/s-2006-959393

Cited by 11 publications

(6 citation statements)

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“…The literature describing the indigenous medicine of Central and South America contains reference to the use of Nectandra species in the therapy of infections of the genitourinary, gastrointestinal and bronchopulmonary systems (López et al, 1995). Recently, biological studies have demonstrated that some extracts from Nectandra species possess antimalarial and antileishmanial activities (Truiti et al, 2005;Muñoz et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)

Filho

Costa

Cunha

et al. 2008

Phytotherapy Research

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Seven tetrahydrofuran lignans, isolated from Nectandra megapotamica (Lauraceae), were evaluated for their in vitro antileishmanial and antimalarial activities. Among the evaluated compounds, machilin-G (1a) and veraguensin (2a) showed the highest antileishmanial activities, displaying for both compounds an IC(50) value of 18 microg/mL and an IC(90) value of 36 microg/mL, while galgravin (1b), nectandrin-A (1c), nectandrin-B (1d), calopeptin (2b) and ganshisandrine (3) were inactive against Leishmania donovani. In the antimalarial assay against Plasmodium falciparum, it was observed that calopeptin (2b) displayed moderate activity, with IC(50) values of 3800 ng/mL (D6 clone) and 3900 ng/mL (W2 clone), while the lignans 1a-1d, 2a and 3 were inactive. In order to compare the effect on the parasites with toxicity to mammalian cells, the cytotoxic activity of the isolated compounds were evaluated against the Vero cells, showing that all evaluated tetrahydrofuran lignans exhibited no cytotoxicity at the maximum dose tested.

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Section: Introductionmentioning

confidence: 99%

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)

Filho

Costa

Cunha

et al. 2008

Phytotherapy Research

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“…Diversas pesquisas têm sido conduzidas com diferentes espécies de Ocotea, visando o isolamento e a caracterização de compostos químicos. Dentre os metabólitos vegetais identifi cados, destacam-se os alcalóides benzilisoquinolínicos e aporfínicos (Vilegas et al, 1989;López et al, 1995;Dias et al, 2003), as lignanas (Morais et al, 1999) e neolignanas (Aiba et al, 1973;Romoff, et al, 1984;Dias et al, 1986;Felicio et al, 1986;Marques et al, 1992;Drewes et al, 1995;Lordello, 1996), os monoterpenos (Diaz et al, 1980), os sesquiterpenos (Aiba et al, 1973;Palomino;Mandonado, 1996) e os fenilpropanóides (Diaz et al, 1980).…”

Section: Introductionunclassified

Análise morfoanatômica de folhas de Ocotea puberula (Rich.) Nees, Lauraceae

Farago¹,

Budel²,

Duarte³

et al. 2005

Rev. bras. farmacogn.

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RESUMO:Ocotea puberula (Rich.) Nees é uma espécie arbórea nativa, que ocorre por toda a América tropical e subtropical, em quase todas as formações fl orestais. É conhecida como guaicá, canela-guaicá e canela-sebo, sendo utilizada por comunidades indígenas no tratamento de tumores e afecções da pele. Este trabalho analisou a morfoanatomia das folhas da espécie, a fi m de fornecer subsídios anatômicos à sua identifi cação. O material botânico foi fi xado e submetido a técnicas usuais de microscopia fotônica e eletrônica de varredura. As folhas são alternas, simples, inteiras, elípticas ou elíptico-lanceoladas e revolutas na base. A anatomia foliar revela a ocorrência de estômatos paracíticos e tricomas tectores unicelulares na face abaxial, mesofi lo dorsiventral, nervura mediana biconvexa, com sistema vascular constituído de feixe único do tipo colateral em arco aberto. Na estrutura anatômica da folha, são observadas células secretoras de substâncias lipofílicas e mucilaginosas. Unitermos:Ocotea puberula, Lauraceae, morfoanatomia.ABSTRACT: "Leaf morpho-anatomical analysis of Ocotea puberula (Rich.) Nees, Lauraceae". Ocotea puberula (Rich.) Nees is a native woody species. It occurs all over tropical and subtropical America, in almost all the forest formations. It is known as guaicá, canela-guaicá and canelasebo, being used by indigenous communities to treat skin diseases and tumours. This work has analysed the leaf morpho-anatomy of the species, in order to supply anatomical information for its identifi cation. The botanical material was fi xed and prepared according to usual optical and scanning microtechniques. The leaves are alternate, simple, entire, elliptical or elliptical-lanceolate and revolute at the base. The leaf anatomy shows paracytic stomata and unicellular non-glandular trichomes on the abaxial surface, dorsiventral mesophyll and biconvex midrib consisting of a collateral bundle in open arc. Oil and mucilage cells are found in leaf anatomical structure.

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“…One report indicates that the aporphine alkaloid (+)-preocoteine is present in the bark of O. gomezii. 38 Several Ocotea essential oils have been studied for their biological activities. For instance, oils from flower calyces and leaves of O. quixos ("flor de canela", American cinnamon) presented in vitro antioxidant, antibacterial and antifungal activities 24,39 and also anti-inflammatory 40 and antiplatelet properties.…”

Section: Introductionmentioning

confidence: 99%

Chemical Analysis of Essential Oils from Ocotea gomezii W.C. Burger and Ocotea morae Gómez-Laur. (Lauraceae) Collected at "Reserva Biológica Alberto M. Brenes" in Costa Rica and their Cytotoxic Activity on Tumor Cell Lines

Chaverri

Díaz²,

Cicció

2011

J. Braz. Chem. Soc.

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A composição química dos óleos essenciais obtidos de folhas, cascas e troncos de Ocotea gomezii e O. morae de populações silvestres da Costa Rica, está sendo descrita pela primeira vez. Os óleos de O. gomezii são constituídos principalmente por sesquiterpenóides enquanto os de O. morae apresentaram mono-e sesquiterpenóides na mesma proporção. A análise da composição química por CG/EM e CG/DIC resultou na identificação de 166 componentes, correspondente a 89,4-98,1% dos óleos totais. Quando comparada a atividade de todos os óleos obtidos sobre linhagens de células CCF-STTG1, Hep3B, HepG2, H-460, AGS, N-87, SW-620, MCF-7 e VERO, observou-se que as células de astrocitoma foram as mais resistentes aos mesmos. Concluiu-se que os óleos essenciais de folhas, cascas e tronco de Ocotea gomezii e Ocotea morae podem conter alguns compostos tóxicos, mas o uso potencial dos mesmos contra as células tumorais foi muito baixo, pois são tóxicos na mesma extensão, para as linhagens de células tumorais e não-tumorais. The chemical composition of the essential oils of the leaves, bark and wood of Ocotea gomezii and O. morae from Costa Rica, were analyzed by capillary GC-FID and GC-MS. The oils of O. gomezii were predominantly composed by sesquiterpenoids whereas the oils of O. morae had both monoterpenoids and sesquiterpenoids. Analysis by GC/MS and GC/FID resulted in the identification of 166 compounds, representing about 89.4−98.1% of the total oils. When we compared the effect of the oils on cell lines (CCF-STTG1, Hep3B, HepG2, H-460, AGS, N-87, SW-620 and MCF-7 and VERO), we found that astrocytoma cells were the most resistant ones. We conclude that the essential oils of Ocotea gomezii and Ocotea morae could have some toxic compounds, but the potential use of them against the tumor cells would be very low, since they could be toxic to tumor and non-tumor cells in the same extent.

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Aporphine Alkaloids of Selected Species ofNectandraandOcotea

Cited by 11 publications

References 0 publications

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae)

Análise morfoanatômica de folhas de Ocotea puberula (Rich.) Nees, Lauraceae

Chemical Analysis of Essential Oils from Ocotea gomezii W.C. Burger and Ocotea morae Gómez-Laur. (Lauraceae) Collected at "Reserva Biológica Alberto M. Brenes" in Costa Rica and their Cytotoxic Activity on Tumor Cell Lines

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