Aportación del tiempo de vuelo y de la modelización de la respuesta a una fuente puntual a las características de funcionamiento del tomógrafo PET/TAC Biograph mCT

Martí-Climent, Josep M.; Prieto, Elena; Domínguez-Prado, Inés; García-Velloso, María José; Rodríguez‐Fraile, Macarena; Arbizu, Javier; Vigil, C.; Caicedo, Carlos; Peñuelas, Iván; Richter, José A.

doi:10.1016/j.remn.2012.07.001

Cited by 18 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PET/CT studies were performed with a Biograph mCT TrueV scanner (Siemens Healthcare, Knoxville, TN, USA), which has a PET that covers a 21.8-cm axial field of view and a 64-detector CT scanner [14]. PET scan is performed in stop-and-go imaging mode, acquiring information in a variable number of bed positions along the patient.…”

Section: Methodsmentioning

confidence: 99%

Effective dose estimation for oncological and neurological PET/CT procedures

et al. 2017

View full text Add to dashboard Cite

BackgroundThe aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds.PET/CT studies of 210 patients were reviewed including Torso (n = 123), Whole body (WB) (n = 36), Head and Neck Tumor (HNT) (n = 10), and Brain (n = 41) protocols with 18FDG (n = 170), 11C-CHOL (n = 10), 18FDOPA (n = 10), 11C-MET (n = 10), and 18F-florbetapir (n = 10). ED was calculated using conversion factors applied to the radiotracer activity and to the CT dose-length product.ResultsTotal ED (mean ± SD) for Torso-11C-CHOL, Torso-18FDG, WB-18FDG, and HNT-18FDG protocols were 13.5 ± 2.2, 16.5 ± 4.5, 20.0 ± 5.6, and 15.4 ± 2.8 mSv, respectively, where CT represented 77, 62, 69, and 63% of the protocol ED, respectively. For 18FDG, 18FDOPA, 11C-MET, and 18F-florbetapir brain PET/CT studies, ED values (mean ± SD) were 6.4 ± 0.6, 4.6 ± 0.4, 5.2 ± 0.5, and 9.1 ± 0.4 mSv, respectively, and the corresponding CT contributions were 11, 14, 23, and 26%, respectively. In 18FDG PET/CT, variations in scan length and arm position produced significant differences in CT ED (p < 0.01). For dual-time-point imaging, the CT ED (mean ± SD) for the delayed scan was 3.8 ± 1.5 mSv.ConclusionsThe mean ED for body and brain PET/CT protocols with different radiopharmaceuticals ranged between 4.6 and 20.0 mSv. The major contributor to total ED for body protocols is CT, whereas for brain studies, it is the PET radiopharmaceutical.

show abstract

Section: Methodsmentioning

confidence: 99%

Effective dose estimation for oncological and neurological PET/CT procedures

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A detailed description of this PET/CT system and its performance characterization can be found elsewhere [21]. This scanner allows point spread function depth-dependent resolution recovery and time-of-flight acquisition and reconstruction [22]. The acquisition protocol consisted of a whole-body CT scan for attenuation correction and a 3D whole-body PET emission scan (5–6 bed positions, 10 min per bed position).…”

Section: Methodsmentioning

confidence: 99%

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

et al. 2017

View full text Add to dashboard Cite

BackgroundThe safety and efficacy of cardiac stem/progenitor cells (CSC) have been demonstrated in previous preclinical and clinical assays for heart failure. However, their optimal delivery route to the ischemic heart has not yet been assessed. This study was designed to determine by a non-invasive imaging technique (PET/CT) the biodistribution and acute retention of allogeneic pig CSC implanted by two different delivery routes, intracoronary (IC) and intramyocardial (IM), in a swine preclinical model of chronic ischemia–reperfusion.MethodsIschemia–reperfusion was induced in six Goettingen hybrid minipigs by 90 min coronary artery occlusion followed by reperfusion. Thirty days later, animals were allocated to receive IC (n = 3) or NOGA®-guided IM injection (n = 3) of 50 million of 18F-FDG/GFP-labeled allogeneic pig CSC. Acute retention was quantified by PET/CT 4 h after injection and cell engraftment assessed by immunohistochemical quantification of GFP+ cells three days post-injection.ResultsBiodistribution of 18F-FDG-labeled CSC was clearly visualized by PET/CT imaging and quantified. No statistical differences in acute cell retention (percentage of injected dose, %ID) were found in the heart when cells were administered by NOGA®-guided IM (13.4 ± 3.4%ID) or IC injections (17.4 ± 4.1%ID). Interestingly, engrafted CSC were histologically detected only after IM injection.ConclusionPET/CT imaging of 18F-FDG-labeled CSC allows quantifying biodistribution and acute retention of implanted cells in a clinically relevant pig model of chronic myocardial infarction. Similar levels of acute retention are achieved when cells are IM or IC administered. However, acute cell retention does not correlate with cell engraftment, which is improved by IM injection.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-017-1157-0) contains supplementary material, which is available to authorized users.

show abstract

“…Recently, the point spread function (PSF) correction and time of flight (TOF) information were incorporated into the reconstruction algorithm [ 8 ]. The PSF information measured in a large number of positions in the field of view (FOV) is incorporated into reconstructed algorithms.…”

Section: Introductionmentioning

confidence: 99%

Improvement in PET/CT image quality in overweight patients with PSF and TOF

et al. 2014

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to evaluate the effect of the point spread function (PSF) and time of flight (TOF) on PET/CT images of overweight patients in relation to the iteration number and the acquisition time.MethodsThis study consisted of a phantom study and a clinical study. The NEMA IEC body phantom and a 40 cm diameter large phantom (LG phantom) simulating an overweight patient were used in this study. Both phantoms were filled with 18F solution with a sphere to background ratio of 4:1. The PET data were reconstructed with the baseline ordered-subsets expectation maximization (OSEM) algorithm, with the OSEM + PSF model, with the OSEM + TOF model and with the OSEM + PSF + TOF model. The clinical study was a retrospective analysis of 66 patients who underwent 18F-FDG PET/CT. The image quality was evaluated using the background variability (coefficient of variance, CVphantom and CVliver) and the contrast (CONTHOT and SNR).ResultsIn phantom study, the CVphantom of the LG phantom was higher than that of the NEMA phantom. The PSF decreased the CVphantom of the LG phantom to the NEMA phantom level. The TOF information accelerated the CVphantom plateau earlier. The best relationship between the CVphantom and the CONTHOT was observed for the OSEM + PSF + TOF. In clinical study, the combination of PSF and TOF decreased the CVliver for overweight patients to that for normal weight patients while it increased the SNR similarly between two patient groups.ConclusionThe combination of the PSF and TOF correction improved the image quality of the LG phantom and overweight patients.

show abstract

Aportación del tiempo de vuelo y de la modelización de la respuesta a una fuente puntual a las características de funcionamiento del tomógrafo PET/TAC Biograph mCT

Cited by 18 publications

References 9 publications

Effective dose estimation for oncological and neurological PET/CT procedures

Effective dose estimation for oncological and neurological PET/CT procedures

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

Improvement in PET/CT image quality in overweight patients with PSF and TOF

Contact Info

Product

Resources

About