Apparate f�r die Ma�analyse

The Chemistry of Diuretics

“…Although aromatic sulfonamides were the first class of compounds to be found to be active both in vitro and in animals and man, they have thus far proved to be too low in diuretic activity to be of value. One of these, p-carboxybenzenesulfonamide (Dirnate, FIGURE 11) was studied in man and dis-~a r d e d .~ 9 Recently, diphenylmethane-4,4'-disulfonamide (FIGURE 11) has been introduced in Germany as a diuretic under the name "Nirexon," but no data are available on its diuretic or anticarbonic anhydrase activity. 66 Sprague: The Chemistry of Diuretics In a cooperative chemical* and pharmacologicalt study of the diuretic properties of the sulfonamides in our lab~ratories,~~-~O we have re-examined compounds of the aromatic type (FIGURE 11) and have observed an unexpected high order of activity among certain derivatives of the benzenedisulfonamides I and 11, particularly in the benzene-l,3-disulfonamide series (11).…”