Apparent accelerated aging of human collagen in diabetes mellitus

Hamlin, Clive R.; Kohn, Robert; Luschin, Jeanne H.

doi:10.2337/diabetes.24.10.902

Cited by 122 publications

(74 citation statements)

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“…These changes in both parameters could be explained on the same basis as those occuring with aging as DM is considered now to represent an aging process with an accelerated rate and with a premature onset. 19,20 In regard to the increase in BT, our suggestion coincides with several workers who reported a drop in catalytic activity of collagenase with an excessive production and deposition of collagen and other extracellular matrix proteins during the progress of DM. 20 These ®ndings will end with an increase in BT.…”

Section: Discussionsupporting

confidence: 69%

Ultra-structural changes in collagen of penile tunica albuginea in aged and diabetic rats

Salama

Kagawa

1999

Int J Impot Res

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Tunica albuginea (TA) of the penis, which has an important role in mechanism of erection, is composed mainly of collagen bundles. Both aging and diabetes mellitus (DM) were reported to be associated with many alterations in collagen content and architecture in several body tissues. So, the aim of this work was to evaluate the effects of both conditions on the collagen bundles of penile TA in rats. Our diabetic models were three groups of Zucker Diabetic Fatty (ZDF) rats with noninsulin-dependent DM (NIDDM) aged 15, 40 and 75 weeks. Their age-matched controls were Zucker Fatty (ZF) rats. TA were excised from the side of mid-penile shaft and were examined by scanning electron microscopy using chemical digestion to extract collagen components. With aging, only the (70 w) ZF rats showed a signi®cant increase in both thickness (P`0.005) and loss of undulation of its bundles (P`0.005) compared with the younger animals. In ZDF animals, a signi®cant gradual increase in bundle thickness (P`0.005) and loss of its undulation (P`0.005) were found as the disease progressed to 40 w duration. Comparing these two parameters between both study groups showed that DM animals had signi®cantly higher bundle thickness (P`0.005) with loss of its undulation (P`0.005) than controls starting from 40 w old. In conclusion, with progress of both aging and NIDDM, an increase in both thickness and loss of undulation of collagen bundles of penile TA was appreciated. The association of DM with aging could represent a cofactor effect that ultimately led to a greater impact on architecture of the bundles. The resulting changes may explain the compromised rigidity of the penis during erection under both conditions.

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Section: Discussionsupporting

confidence: 69%

Ultra-structural changes in collagen of penile tunica albuginea in aged and diabetic rats

Salama

Kagawa

1999

Int J Impot Res

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“…In this regard, the volume proportion of alveolar walls was increased at the expense of alveolar air, and air spaces were diminished in size [25]. Changes in collagen metabolism have been related to an apparent accelerated ageing of human collagen in diabetes, probably because one or more properties of collagen could be altered in ways that simulate accelerated ageing [26].…”

Section: Histopathological Evidencementioning

confidence: 97%

“…It is also conceivable that the abovementioned functional deficits can depress the host defense of the airways and the mucociliary clearance, thereby helping to promote the development of lower respiratory tract infections and/or to delay healing. Finally, the derangements of the autonomic innervation with consequent reduction of both peripheral and central chemosensibility may be involved in the altered perception of breathlessness and in anomalous patterns in the ventilatory response to exercise, as frequently observed in diabetic patients with dysautonomia [26,59]. Therefore, periodic monitoring of the respiratory function in patients with diabetes is an appropriate action, to measure the progression of systemic microangiopathy, and could have prognostic significance since the reduction in some functional indices has been shown to correlate with mortality.…”

Section: Discussionmentioning

confidence: 99%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

145

112

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■ AbstractSeveral abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes.

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“…Pulmonary damage in diabetic patients arises from several mechanisms, including biochemical changes in connective tissue, especially in collagen and elastin [2,3]. Non-enzymatic protein glycosylation induced by chronic hyperglycaemia has been proposed as one of the determinant mechanisms leading to diabetic microangiopathy [4,5].…”

Section: Introductionmentioning

confidence: 99%

Diffusing capacity for carbon monoxide in children with type 1 diabetes

et al. 2004

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Aims/hypothesis. Few data are available on lung dysfunction in children with diabetes. We studied the association of pulmonary function variables (flows, volumes and alveolar capillary diffusion) with disease-related variables in children with type 1 diabetes mellitus. Methods. We studied 39 children with type 1 diabetes (mean age 10.9±2.6 years, disease duration 3.6±2.4 years, insulin·kg −1 ·day −1 0.77±0.31) and 30 healthy control children (mean age 10.4±3.0 years). Pulmonary function tests included spirometry, N 2 wash-out and the single-breath diffusing capacity for carbon monoxide (DL CO Conclusions/interpretation. In children with type 1 diabetes, the diffusing capacity diminishes early in childhood and is associated with poor metabolic control. Although low DL CO /V A levels in these children probably reflect pulmonary microangiopathy induced by type 1 diabetes, other factors presumably influencing CO diffusion capacity measurements (e.g. a left shift in HbA 1 c resulting in high O 2 binding and low CO binding) could explain the apparent capillary and alveolar basal membrane dysfunction.Keywords Children · Lung function · Pulmonary gas exchange · Type 1 diabetes mellitus

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Apparent accelerated aging of human collagen in diabetes mellitus

Cited by 122 publications

References 0 publications

Ultra-structural changes in collagen of penile tunica albuginea in aged and diabetic rats

Ultra-structural changes in collagen of penile tunica albuginea in aged and diabetic rats

The Diabetic Lung - A New Target Organ?

Diffusing capacity for carbon monoxide in children with type 1 diabetes

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