Apparent diffusion coefficient-based differentiation of cystic lesions of the mandible

Application of diffusion kurtosis imaging to odontogenic lesions: Analysis of the cystic component

“…Our ADC results were similar to those of previous studies and showed that the mean ADC of odontogenic cysts ranged widely (0.538-2.47 3 10 23 mm 2 /s). 9,10 In most of our odontogenic cyst cases, inflammatory cell infiltration of varying degrees was confirmed histopathologically. Such conditions might cause the ADCs of odontogenic cysts to have a wide range.…”

“…Our ADC results were similar to those of previous studies and showed that the mean ADC of odontogenic cysts ranged widely (0.538-2.47 3 10 23 mm 2 /s). 9,10 In The area under the ROC curve for the D1K model was 0.840 (95% CI 0.685-0.996), which was higher than that for the ADC (0.681; 95% CI 0.491-0.870), although the difference did not reach significance (P < 0.05). The D1K model (-1.13) and ADC (1.09) had suitable threshold values for differentiating KCOTs from odontogenic cysts (*1 and *2 5 threshold values).…”

“…18 There have been few studies in which DKI has been applied to the head and neck region. 20,21 According to Sumi et al 9 and Eida et al, 10 it had been thought that ADC reflects the fluid variations as differences in viscosity, whereas we hypothesized that the floating substances in the fluid such as desquamated keratin in KCOTs, cell debris in RCs, and inflammatory cell infiltration could also restrict diffusion of water molecules in the fluid. Therefore, ADC may be affected by the restricted diffusion due to viscosity of the fluid and floating substances, and the individual effects of those factors could not be evaluated independently.…”

“…[3][4][5] To evaluate the extent and morphological characteristics of these lesions and for diagnosis, multidetector computed tomography (MDCT) and cone-beam CT (CBCT) are generally performed. Recently, magnetic resonance imaging (MRI) has been applied to odontogenic lesions, and advanced techniques such as dynamic contrast-enhanced MRI [6][7][8] and diffusion-weighted imaging (DWI) [9][10][11] have been reported. Based on DWI studies, the apparent diffu-sion coefficient (ADC) was proposed to be useful for differentiating between KCOTs and ameloblastomas, whereas the ADC contributed little to differentiating KCOTs from odontogenic cysts such as RCs and DCs.…”

“…Based on DWI studies, the apparent diffu-sion coefficient (ADC) was proposed to be useful for differentiating between KCOTs and ameloblastomas, whereas the ADC contributed little to differentiating KCOTs from odontogenic cysts such as RCs and DCs. [9][10][11] Diffusion kurtosis imaging (DKI) is an approach for quantitative evaluation with DWI. 12 Thus, the purposes of this retrospective study were to assess the feasibility of using DKI to assess common odontogenic lesions and to compare its diagnostic ability versus that of the ADC for differentiating KCOTs from odontogenic cysts.…”