Apparent diffusion coefficient measurements in the differentiation between benign and malignant neck masses

Salem, Faten Mohammed; Elshafey, Rasha; Elmahalawy, Mohamed; Elshaeny, Seham

doi:10.1016/j.ejrnm.2014.01.011

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…The mean ADC values of the benign and metastasis groups were equal to 1.06 ± 0.12 × 10 -3 mm 2 /s and 0.90 ± 0.10 × 10 -3 mm 2 /s, respectively. The mean ADC values of the benign cervical lymph nodes were significantly higher than metastatic type that was similar to results of other studies ( Ali, 2012;Dawood et al, 2014;Razek et al, 2006;Salem et al, 2014;Liang et al, 2017;Perrone et al, 2011). Ali et al, (2012) reported that the mean ADC value of metastatic lymph nodes (0.92 ± 0.13 × 10 -3 mm 2 /s) was significantly lower than mean ADC of benign cervical lymph nodes (1.51 ± 0.36 × 10 -3 mm 2 /s) (p< 0.0001).…”

Section: Discussionsupporting

confidence: 91%

“…In general, invasive methods such as: biopsy and dissection, and their side effects, as well as the low accuracy of other diagnostic imaging methods, such as ultrasound, CT scan, conventional MRI, and limitations of SPECT and PET imaging all have led researchers to make more effort in order to find a method that reduces the time, cost, and complicated diagnostic risks (Razek et al, 2006;Holzapfel et al, 2009;Salem et al, 2014;Liang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…ADC is a quantitative parameter that is acquired through DWI images and can exclude the T2 shine-effect, also provide quantitative assessment of water diffusivity in the target tissues which makes it easier to differentiate between lesions (ElSaid et al, 2014;Salem et al, 2014;Hasanzadeh et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Conventional imaging including: Ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) relies on the morphological criteria of the lymph node including maximum short axis diameter, lymph node hilum loss and necrosis along with heterogeneous pattern of post contrast enhancement and perinodal infiltration. These image methods can diagnose cervical lymphadenopathy, but, they cannot differentiate benign lymph nodes from malignant ones accurately ( Ali, 2012;Dawood et al, 2014;and El Hariri, 2017;Razek et al, 2006;Holzapfel et al, 2009;Salem et al, 2014;Liang et al, 2017). Another imaging modalities such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) can be helpful in this differentiation but they are expensive and are limited to low spatial resolution, as well as false diagnosis of physiological and inflammatory lymph nodes ( Ali, 2012;Ali and El Hariri, 2017;Razek et al, 2006;Holzapfel et al, 2009).…”

Section: Diagnostic Value Of Diffusion Weighted Magnetic Resonance Immentioning

confidence: 99%

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Diagnostic Value of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Metastatic Neck Lymph Nodes in Head and Neck Cancer: A Sample of Iranian Patient

Alamolhoda

Faeghi

Bakhshandeh

et al. 2019

Asian Pac J Cancer Prev

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Objective: To evaluate the diagnostic value of DWI in assessment of metastatic neck lymph node in a sample of Iranian patients with Head and Neck cancer. Methods: 25 patients with 80 neck lymph nodes were analyzed using 1.5 T MRI. DWI was performed with b values of 0 and 1,000 s/mm 2. Short axis diameter and ADC values (min, max and mean) were calculated for metastatic and non-metastatic neck LNs and results were compared with histopathological findings. The optimal ADC thresholds were analyzed using receiver coefficient characteristic (ROC) curves for discriminating between metastatic and benign neck lymph nodes. Result: Histopathological findings revealed that there are 45% (n=36) metastatic and 55% (n=44) non-metastatic neck LNs respectively. There was no statistically significant difference in short axis diameter between the two groups (p = 0.346). However, The ADC values of metastatic neck LNs were significantly lower than those of non-metastatic neck LNs (p < 0.001); 0.90 ± 0.10 × 10-3 mm 2 /s vs 1.06 ± 0.12 × 10-3 mm 2 /s (ADC mean), 0.78 ± 0.08 × 10-3 mm 2 /s vs 0.92 ± 0.20× 10-3 mm 2 /s (ADC min) and 1.02 ± 0.12 × 10-3 mm 2 /s vs 1.24 ± 0.15 × 10-3 mm 2 /s (ADC max). The optimal mean ADC threshold value was equal to 0.996 × 10-3 mm 2 /s for differentiating malignant from benign lymph nodes with sensitivity, specificity and accuracy of 80.56 %, 77.27 % and 71.59 % respectively. Conclusion: MR diffusion imaging and ADC values as a non-invasive technique can assess metastatic neck LNs in head and neck cancer with higher sensitivity, specificity and accuracy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Diagnostic Value Of Diffusion Weighted Magnetic Resonance Immentioning

confidence: 99%

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Diagnostic Value of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Metastatic Neck Lymph Nodes in Head and Neck Cancer: A Sample of Iranian Patient

Alamolhoda

Faeghi

Bakhshandeh

et al. 2019

Asian Pac J Cancer Prev

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“…DWI can differentiate the viable and necrotic portions of head and neck tumors. The ADC can discriminate benign lesions from malignant tumors and tumor necrosis from abscesses [10].…”

Section: Introductionmentioning

confidence: 99%

Value of diffusion MRI versus [18F]FDG PET/CT in detection of cervical nodal metastases in differentiated thyroid cancer patients

et al. 2022

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Background:In differentiated thyroid cancer (DTC) patients, cervical nodal metastasis is a negative prognostic factor. Preoperative imaging plays an important role in treatment planning for nodal metastasis and recurrence.The aim of the study is to compare the diagnostic performance of the diffusion-weighted magnetic resonance imaging (DW-MRI) and the F-18 flurodeoxyglucose positron emission computed tomography ([ 18 F]FDG PET/CT) in detection of cervical nodal deposits in DTC patients. Materal and methods:The study was conducted on 30 patients, each performed both modalities just before the surgery. The gold standard was the pathological specimens with post-operative clinico-radiological follow-up, to assess the diagnostic performance of each modality. Results:Based on pathological and post-operative clinico-radiological follow up data. Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) and accuracy were 84%, 80%, 50%, 95% and 83% for PET/CT compared to 84%, 60%, 42.8%, 91.3% and 80% for DW-MRI.On comparing the diagnostic performance of combined DW-MRI and PET/CT to each modality alone, the sensitivity and NPV were improved to 96% and 80% respectively.Conclusions: [ 18 F]FDG PET/CT study is a valuable diagnostic modality for the assessment of cervical nodal deposits in DTC patients, surpassing DW-MRI. Combined PET/CT and DW-MRI techniques seemed to have synergistic performance, mainly in terms of sensitivity and NPV, for detection of nodal metastases.

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Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis

et al. 2019

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Apparent diffusion coefficient measurements in the differentiation between benign and malignant neck masses

Cited by 5 publications

References 13 publications

Diagnostic Value of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Metastatic Neck Lymph Nodes in Head and Neck Cancer: A Sample of Iranian Patient

Diagnostic Value of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Metastatic Neck Lymph Nodes in Head and Neck Cancer: A Sample of Iranian Patient

Value of diffusion MRI versus [18F]FDG PET/CT in detection of cervical nodal metastases in differentiated thyroid cancer patients

Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis

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