As it is popular research field, extensive research has been performed in various areas of nanofluids, and most of the studies have demonstrated significant enhancements in their thermophysical properties and thermal transport performance compared to those of conventional thermal fluids. However, there have been unanimous conclusions regarding such enhancements and their underlying mechanisms. Nanofluids’ potential and thermal applications mainly depend on their convective and boiling heat transfer performances, which are also not unbiased in the literature. On top of this, a major challenge with nanofluids is obtaining sustainable stability and persistent properties over a long duration. All these issues are very crucial for nanofluids’ development and applications, and a lot of research in these areas has been conducted in recent years. Thus, this Special Issue, featuring a dozen of high-quality research and reviews on different types of nanofluids and their important topics related to thermophysical and electrical properties as well as convective and boiling heat transfer characteristics, is of great significance for the progress and real-world applications of this new class of fluids.