Appearance of systemic granulomatosis is modulated by the dietary supplementation of vitamin E and C in meagre (Argyrosomus regius) larvae fed inert microdiets

Abstract

Appearance of systemic granulomatosis is modulated by the dietary supplementation of vitamin E and C in meagre (Argyrosomus regius) larvae fed inert microdiets [Supplementation of vitamin E and C prevent granulomatosis in meagre larvae].

The effect of fish stocking density and dietary supplementation of vitamin C and micronutrients (Mn, Zn and Se) on the development of systemic granulomatosis in juvenile meagre ( Argyrosomus regius )

“…In the present study, a modest correlation between the TBARS levels and the appearance of granulomas in liver (R 2 = 0.651, y = 487.63x + 43.914) and heart (R 2 = 0.648, y = 206.75x + 11.087) was observed. Probably this correlation is more attenuated than the observed in previous studies in meagre larvae at 30 dph (R 2 = 0.948, y = 0.084x − 4.3924) (Ruiz et al, 2019a) and 44 dph (R 2 = 0.892, y = 0.0446x + 0.0756) (Ruiz et al, 2019b), due to the higher initial incidence of granulomas in juvenile meagre in the present trial (61%).…”

“…In previous studies in meagre larvae, a strong positive correlation between the TBARS content and the appearance of granulomas was observed (Ruiz et al, 2019a(Ruiz et al, ,2019b, suggesting a possible relationship between lipid peroxidation and the appearance of granulomas. In the present study, a modest correlation between the TBARS levels and the appearance of granulomas in liver (R 2 = 0.651, y = 487.63x + 43.914) and heart (R 2 = 0.648, y = 206.75x + 11.087) was observed.…”

“…Although some infectious agents like the bacteria Nocardia spp. can produce granulomatosis in meagre (Elkesh et al, 2012), there are evidences that this pathology can be caused by a nutritional imbalance, given that an infectious agent could not be associated with the appearance of granulomas (Katharios et al 2011;Cotou et al, 2016;Ruiz et al, 2018Ruiz et al, , 2019aRuiz et al, ,2019bCarvalho et al 2018).…”

“…Granulomas can firstly appear at very early stages in meagre larvae (20 days post hatching; dph), although its development could be avoided by the modulation of the feeding sequence (Ruiz et al, 2019a) and by using a microdiet with high enough levels of the antioxidant vitamins E and C (Ruiz et al, 2019b). Inadequate levels of these two vitamins could cause a nutritional imbalance between pro-oxidants and antioxidants, which could in turn lead to a status of oxidative stress.…”

The importance of vitamin E for farmed fish—A review

“…[30][31][32] For instance, when gilthead seabream (Sparus aurata) larvae were fed increased dietary PUFA levels, elevation of VE supplementation improved growth, survival and PUFA contents in fish polar lipids. 30 Early life stages also require more VE than older stages as has been shown in gilthead seabream, 29,33 meagre (Argyrosomus regius) [34][35][36] and European seabass (Dicentrarchus labrax). 31 The relationship between VE requirement and water temperature is also evident.…”