Appendage loss and regeneration in arthropods

Maruzzo, Diego; Bonato, Lucio; Brena, Carlo; Fusco, Giuseppe; Minelli, Alessandro

doi:10.1201/9781420037548.ch9

Cited by 38 publications

(49 citation statements)

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“…Crustacea generally have the capacity to loose appendices by autotomy or appendotomy at certain risks or physical stress, as occurs generally in arthropods (Maruzzo et al 2005). This phenomenon has been registered, under laboratory conditions, in decapods of the Middle Paraná River area as a consequence of chemical stress caused by agrotoxics (Montagna and Collins 2006).…”

Section: Morphologymentioning

confidence: 98%

Littoral Communities. Macrocrustaceans

Collins

Williner

Giri

2007

The Middle Paraná River

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Section: Morphologymentioning

confidence: 98%

Littoral Communities. Macrocrustaceans

Collins

Williner

Giri

2007

The Middle Paraná River

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“…An extended growth period follows regeneration once patterning is complete. Full replacement of the appendage can take years in some large terrestrial salamanders (Young, Bailey & Dalley, 1983 b ), and is restricted by moulting times in arthropods such that a small limb emerges and grows after each successive moult (Maruzzo et al , 2005). That epimorphic regeneration of appendages appears highly conserved is fascinating given the great phylogenetic distance among these species, although it remains unclear if the molecular mechanisms underlying these processes are homologous across taxa.…”

Section: Introductionmentioning

confidence: 99%

The influence of fundamental traits on mechanisms controlling appendage regeneration

et al. 2011

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One of the most compelling questions in evolutionary biology is why some animals can regenerate injured structures while others cannot. Appendage regeneration appears to be common when viewed across the metazoan phylogeny, yet this ability has been lost in many taxa to varying degrees. Within species, the capacity for regeneration also can vary ontogenetically among individuals. Here we argue that appendage regeneration along the secondary body axis may be constrained by fundamental traits such as body size, aging, life stage, and growth pattern. Studies of the molecular mechanisms affecting regeneration have been conducted primarily with small organisms at early life stages. Such investigations disregard the dramatic shifts in morphology and physiology that organisms undergo as they age, grow, and mature. To help explain interspecific and intraspecific constraints on regeneration, we link particular fundamental traits to specific molecular mechanisms that control regeneration. We present a new synthesis for how these fundamental traits may affect the molecular mechanisms of regeneration at the tissue, cellular, and genomic levels of biological organization. Future studies that explore regeneration in organisms across a broad phylogenetic scale, and within an ontogenetic framework, will help elucidate the proximate mechanisms that modulate regeneration and may reveal new biomedical applications for use in regenerative medicine.

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“…Decorator crabs (Malacostraca, Decapoda: Majoidea) hide from or ward off predators by attaching camouflaging debris and/or noxious sedentary animals and/or plants to their exoskeleton [36]. And various arthropods cast off a limb when under threat -a behavior called autotomy -thus distracting the attacker and creating an opportunity to escape; once in safety, the lost body part is regenerated [37].…”

Section: Classification Of Arthropodamentioning

confidence: 99%

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

Mans¹

2017

J Transl Sci

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Drug discovery and development programs have historically mainly focused on plants with medicinal properties and the extensive knowledge of traditional healers about these plants. More recently, the vast array of marine invertebrates and insects throughout the world have been recognized as additional sources for identifying unusual lead compounds to obtain structurally novel and mechanistically unique therapeutics. The results from these efforts are encouraging and have yielded a number of clinically useful drugs. However, many arthropods other than insects -such as spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes -also produce hundreds of bioactive substances in their venom that may become useful in the clinic. Many of these chemicals are defensive and predatory weapons of these creatures and have been refined during millions of years of evolution to rapidly and with high specificity and high affinity shut down critical molecular targets in prey and predators. Exploration of these compounds may lead to the development of, among others, novel drugs for treating diseases caused by abnormalities in humans in the same (evolutionary conserved) molecular targets such as erectyle dysfunction, botulism, and autoimmune disorders, as well as the identification of novel antineoplastic, antimicrobial, and antiparasitic compounds. This paper addresses the importance of bioactive compounds from spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes to these advances.

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Appendage loss and regeneration in arthropods

Cited by 38 publications

References 0 publications

Littoral Communities. Macrocrustaceans

Littoral Communities. Macrocrustaceans

The influence of fundamental traits on mechanisms controlling appendage regeneration

Exploring the global animal biodiversity in the search for new drugs – Spiders, scorpions, horseshoe crabs, sea spiders, centipedes, and millipedes

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