Mass in right iliac fossa is one of the common clinical surgical entity with varied etiologies, involving intra peritoneal organs like vermiform appendix, caucus, ileum, retroperitoneal structures like kidneys, blood vessels etc., and abdominal wall masses like desmoids tumor. To know the etiology and the various pattern of presentation of right iliac fossa mass in our institution a retrospective study was designed including all adult patients diagnosed to have a mass in right iliac fossa. Pediatric patients and female patients having a mass due to gynaecological diseases were excluded from this study. All clinical parameters, radiological investigations, biochemical investigations, endoscopy, cytology, biopsy were collected and analysed systematically.