Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review

Aljarabah, Moayad; Borley, Neil; Wheeler, James M.

doi:10.1186/1477-7800-4-20

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…In order to avoid entrapment of tumour cells at operative sites and to destroy small residual mucinous tumour nodules, cytoreductive surgery is combined with intraperitoneal chemotherapy or to be more accurate intraperitoneal hyperthermic chemoperfusion. The latter includes 5-fluoro-2'-deoxyuridine (FUDR) plus leucovorin (LV) [ 15 ], 1000 mg/m 2 and 240 mg/m 2 respectively, either 200 mg/M 2 of oxaliplatin for a 2-h chemoperfusion [ 16 ], or combination of mytomicin-C (MMC) with either cisplatin [ 17 ] or fluorouracil [ 18 ]. Particularly intraperitoneal chemotherapy with mitomycin at 42 degrees C is a well tested chemotherapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case

et al. 2010

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Introduction: Mucinous adenocarcinoma is a rare neoplasm of the gastrointestinal tract and one of the three major histological subtypes of the primary appendiceal adenocarcinoma. The most common type of presentation is that of acute appendicitis and the diagnosis is usually occurred after appendectomy. The accurate preoperative diagnosis and management of the above condition represents a real challenge when uncommon anatomic anomalies such intestinal malrotation and situs inversus take place. Situs inversus totalis with an incidence of 0.01% is an uncommon condition caused by a single autosomal recessive gene of incomplete penetration in which the major visceral organs are mirrored from their normal positions. Case presentation:We present an unusual case of a 59 years old, previously healthy man presented with a left lower quadrant abdominal pain, accompanied with low fever, leukocytosis, anorexia and constipation. A chest radiograph demonstrated dextrocardia with a right side positioned stomach bubble. Both preoperative US and CT scan of the abdomen and pelvis declared situs inversus, with a characteristic thickening in its wall, appendix situated in the left lower quadrant of the abdomen. These findings reached to the diagnosis of acute appendicitis with situs inversus and a standard appendicectomy was performed. Pathologic evaluation established primary mucinous adenocarcinoma of the appendix and three months afterwards the patient underwent a subsequent extended left hemicolectomy. Conclusion:In conclusion, the occurrence of primary appendiceal mucinous adenocarcinoma along with situs inversus, definitely accounts as a unique clinical case. Even synchronous manifestation of primary mucinous adenocarcinoma of the appendix and situs inversus totalis represents an unusual anatomo-pathological entity, all physicians should be familiar having the knowledge to make an appropriate and accurate diagnosis that will lead to prompt and correct treatment.

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Section: Introductionmentioning

confidence: 99%

Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case

et al. 2010

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“…Appendiceal malignancy is uncommon, accounting for 0.4–1% of all gastrointestinal malignancies [ 2 ]. There are five main subtypes: colonic type adenocarcinoma, mucinous adenocarcinoma, goblet cell carcinoid, malignant carcinoid and signet cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Closed loop large bowel obstruction due to appendiceal signet cell carcinoma

Phan¹,

Teo²,

Nalliah³

2021

Journal of Surgical Case Reports

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Signet cell carcinoma of the appendix is the rarest and the most aggressive subtype of appendiceal malignancy, typically presenting with non-specific symptoms. We describe a case of a 62-year-old male with large bowel obstruction, with computed tomography demonstrating dilated large bowels from caecum to proximal sigmoid colon and pneumoperitoneum. Intraoperatively, closed loop obstruction caused by dense adherence of sigmoid colon to caecum was noted, which had resulted in caecal perforation. Histopathology study indicated primary appendiceal malignancy of signet cell morphology with intraperitoneal spread to sigmoid colon. Large bowel obstruction from appendiceal malignancy has rarely been reported and similar presentations have not been described in the existing literature. When left-sided large bowel obstruction is suspected to be caused by a malignant stricture, it is essential to consider transperitoneal spread of appendiceal malignancy as potential aetiology, particularly in the elderly.

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“…Primary adenocarcinomas of the appendix can be of three subtypes: mucinous (55%), colonic type (34%) and adenocarcinoid (11%) [7], and most neoplasms are only identified after histological examination [8], being found in approximately 0.9%-1.4% of all appendectomy specimens.…”

Section: Discussionmentioning

confidence: 99%

Primary Adenocarcinoma of the Appendix Mimicking Appendicitis: A Case Report

Rashid¹,

Barnes²

2012

Surgery

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The authors present an unusual case of a 55 year old man who presented with right sided abdominal pain for which he underwent a CT scan. This showed a perforated appendix and he was initially treated in the outpatient setting, before having an appendicectomy, the histology of which showed adenocarcinoma of the appendix. He underwent a right hemicolectomy and adjuvant chemotherapy. He has remained well from his carcinoma point of view, but unfortunately experienced serious side effects from his chemotherapy regime.

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Appendiceal adenocarcinoma presenting as left-sided large bowel obstruction, a case report and literature review

Cited by 8 publications

References 10 publications

Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case

Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case

Closed loop large bowel obstruction due to appendiceal signet cell carcinoma

Primary Adenocarcinoma of the Appendix Mimicking Appendicitis: A Case Report

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