Appendiceal Neuroendocrine Tumours in Childhood

Virgone, Calogero; Cecchetto, Giovanni; Alaggio, Rita; Ferrari, Andrea; Bisogno, Gianni; Conte, Massimo; Inserra, Alessandro; Fagnani, Anna Maria; Indolfi, Paolo; Salfi, Nunzio; Dall’Igna, Patrizia

doi:10.1097/mpg.0000000000000217

Cited by 43 publications

(60 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CgA or 5-HIAA) nor indirect noninvasive imaging have been studied for their sensitivity for detecting metastasis or local tumor recurrence in this specific setting. Cumulative exposure to irradiation with repetitive scanning may be an argument to use MRI rather than CT scanning in younger and particularly in fertile patients (female or male) [45]. The role of colonoscopy or transabdominal ultrasound has not been established in this setting and is not recommended.…”

Section: Follow-upmentioning

confidence: 99%

“…Cross-sectional imaging using CT or MRI with modern protocols should be used to rule out locoregional or distant metastasis [42,43,44,45]. NEN limited to the appendix may be detected by transabdominal ultrasonography, which in spite of its investigator-dependent limitations is the least invasive procedure but has not been validated.…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

“…In the context of the potentially increased incidence of secondary neoplasms, general recommendations regarding colorectal cancer screening should be followed. Somatostatin receptor imaging using either indium-111-somatostatin receptor scintigraphy (including SPECT) or positron emission tomography (PET) scanning using gallium-68-labelled somatostatin analogues in combination with CT may be considered in cases where curative resection is not completely assured or where distant metastasis is suspected [45]. …”

Section: Diagnostic Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

et al. 2016

View full text Add to dashboard Cite

Section: Follow-upmentioning

confidence: 99%

Section: Diagnostic Proceduresmentioning

confidence: 99%

Section: Diagnostic Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

et al. 2016

View full text Add to dashboard Cite

“…In addition, the TREP and EXPeRT groups have developed treatment and staging recommendations for selected rare cancers and have identified a group of experts who assist in consultations and clinical decisions. 2,[7][8][9][10] The EUROCARE (European Cancer Registry) project, a population-based cancer database that reports the survival rates from 74 population-based registries in 29 European countries, has also served as an important resource for investigators and offers opportunities for improved collaboration.…”

Section: Collaborative Efforts To Study Rare Childhood Cancersmentioning

confidence: 99%

Rare Tumors in Children: Progress Through Collaboration

Pappo

Furman

Schultz

et al. 2015

JCO

Self Cite

View full text Add to dashboard Cite

Rare pediatric tumors account for approximately 10% of all childhood cancers, which in themselves are a rare entity. The diverse histologies and clinical behaviors of rare pediatric tumors pose challenges to the investigation of their biologic and clinical features. National and international cooperative groups such as the Rare Tumor Committee of the Children's Oncology Group, Rare Tumors in Pediatric Age Project, and European Cooperative Study Group for Pediatric Rare Tumors have developed several initiatives to advance knowledge about rare pediatric cancers. However, these programs have been only partially effective, necessitating the development of alternative mechanisms to study these challenging diseases. In this article, we review the current national and international collaborative strategies to study rare pediatric cancers and alternative methods under exploration to enhance those efforts, such as independent registries and disease-specific, National Cancer Institute–sponsored clinics.

show abstract

“…To locate the primary tumour site and assess the disease stage, SRI in correlation with multiphase CT/MRI is recommended. In the case of incomplete surgery of the NEN of the appendix or if distant metastases are suspected, SRI should be performed [67].…”

mentioning

confidence: 99%

Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Bednarczuk¹,

Bolanowski²,

Zemczak³

et al. 2017

Endokrynologia Polska

View full text Add to dashboard Cite

 224Neuroendocrine neoplasms of the small intestine and appendix -management guidelines Bednarczuk Tomasz et al. SZKOLENIE PODYPLOMOWE AbstractThis study presents the revised Polish guidelines regarding the management of patients suffering from neuroendocrine neoplasms (NENs) of the small intestine and appendix. The small intestine, especially the ileum, is the most common location for these neoplasms. Most are well differentiated and slow growing. Their symptoms may be atypical, which can result in delayed or accidental diagnosis. Appendicitis is usually the first manifestation of NEN in this location. Typical symptoms of carcinoid syndrome occur in approximately 20-30% of patients suffering from small intestinal NENs with distant metastases. The main cause of death in patients with carcinoid syndrome is carcinoid heart disease.The most useful laboratory test is the determination of chromogranin A, while concentration of 5-hydroxyindoleacetic acid is helpful in the diagnostics of carcinoid syndrome. For visualisation, ultrasound, computed tomography, magnetic resonance imaging, colonoscopy, video capsule endoscopy, double-balloon enteroscopy, and somatostatin receptor scintigraphy may be used. A detailed histological report is crucial for the proper diagnostics and therapy of NENs of the small intestine and appendix. The treatment of choice is surgical management, either radical or palliative. The pharmacological treatment of the hormonally active and non-active small intestinal NENs as well as NENs of the appendix is based on long-acting somatostatin analogues. In patients with generalised NENs of the small intestine in progress during the SSA treatment, with good expression of somatostatin receptors, the first-line treatment should be radioisotope therapy, while targeted therapies, such as everolimus, should be considered afterwards. When the above therapies are exhausted, in certain cases chemotherapy may be considered.(Endokrynol Pol 2017; 68 (2): 223-236)

show abstract

Appendiceal Neuroendocrine Tumours in Childhood

Cited by 43 publications

References 43 publications

ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

Rare Tumors in Children: Progress Through Collaboration

Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Contact Info

Product

Resources

About