Appendiceal tumor incidence and an in-depth look at appendiceal neuroendocrine neoplasm in a cohort of 8,162 appendectomies: Full dataset

Rosenblum, Rachel Chava; Klein, Noa; Paran, Haim; Shmuel, Avital; Kravtsov, Vladimir; Rotman-Pikielny, Pnina; Twito, Orit

doi:10.1016/j.dib.2020.106456

Cited by 4 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many ANETs cases are diagnosed accidentally in surgical specimens following appendectomy performed due to acute appendicitis or for other reasons. ANETs are found in less than 2% of surgical specimens following appendectomy; neverthe- Guidelines less, ANETs are the most common neoplasm of the appendix [91,92]. Most ANETs cases are small (i.e.…”

Section: Neuroendocrine Neoplasms Of the Appendixmentioning

confidence: 99%

“…Some investigators have demonstrated that the presence of regional lymph node metastases is a prognostic factor in ANET [101]. Distant metastases in the course of ANET (usually to the liver) are rare [90,91].…”

Section: Prognostic Factors In Anetmentioning

confidence: 99%

“…Niektórzy badacze wykazali, że obecność przerzutów w regionalnych węzłach chłonnych jest czynnikiem rokowniczym w ANET [101]. Przerzuty odległe w przebiegu ANET (zwykle do wątroby) występują rzadko [90,91].…”

Section: Minimalny Zakresunclassified

“…Wiele przypadków ANETs to znaleziska przypadkowe w materiale operacyjnym wyrostka usuniętego z powodu ostrego zapalenia albo z innych przyczyn. ANETs stwierdza się w mniej niż 2 % preparatów operacyjnych po appendektomii, ale mimo to są to najczęstsze nowotwory wyrostka robaczkowego [91,92]. Większość przypadków ANETs to guzy małe (tj.…”

Section: Conflict Of Interestunclassified

See 3 more Smart Citations

Neuroendocrine neoplasms of the small intestine and the appendix — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

Bednarczuk

Zemczak²,

Bolanowski³

et al. 2022

Endokrynol Pol

View full text Add to dashboard Cite

Updated Polish recommendations for the management of patients with neuroendocrine neoplasms (NENs) of the small intestine (SINENs) and of the appendix (ANENs) are presented herein. The small intestine, and especially the ileum, is one of the most common locations for these neoplasms. Most of them are well-differentiated and slow-growing tumours; uncommonly -neuroendocrine carcinomas. Their symptoms may be untypical, and their diagnosis may be delayed or accidental. Most often, the first manifestation of ANEN is their acute inflammation. Typical symptoms of carcinoid syndrome occur in approximately 20-30% of SINENs patients with distant metastases. In laboratory diagnostics, it is most useful to determine the concentration of chromogranin A (CgA) and assessment of urinary or plasma the 5-hydroxyindoleacetic acid concentration is helpful in the diagnosis of carcinoid syndrome. The most commonly used imaging methods are ultrasound (US) examination, computed tomography (CT), magnetic resonance imaging (MRI), colonoscopy, and somatostatin receptor imaging (SRI). Histopathological examination is crucial for the proper diagnosis and treatment of patients with SINENs and ANENs. The treatment of choice is a surgical procedure, either radical or palliative. Long-acting somatostatin analogues (SSAs) are essential in the medical treatment of functional and non-functional SINENs. In patients with SINENs, at the stage of dissemination with progression during SSAs treatment, with high expression of somatostatin receptors on functional imaging, radioligand therapy should be considered first followed by targeted therapies -everolimus. Recommendations for patient monitoring are also presented.

show abstract

Section: Neuroendocrine Neoplasms Of the Appendixmentioning

confidence: 99%

Section: Prognostic Factors In Anetmentioning

confidence: 99%

Section: Minimalny Zakresunclassified

Section: Conflict Of Interestunclassified

See 2 more Smart Citations

Neuroendocrine neoplasms of the small intestine and the appendix — update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne jelita cienkiego i wyrostka robaczkowego — uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

Bednarczuk

Zemczak²,

Bolanowski³

et al. 2022

Endokrynol Pol

View full text Add to dashboard Cite

show abstract

“…Appendiceal neuroendocrine neoplasm (ANEN) are diagnosed in approximately 0.5% of appendectomies (1)(2)(3)(4)(5). These tumors usually harbor excellent prognosis, and rarely require further treatment beyond appendectomy (6,7).…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathologic characteristics of appendiceal neuroendocrine neoplasms diagnosed during pregnancy

Twito

Akirov²,

Rosenblum³

et al. 2023

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

IntroductionAlthough appendicitis occurs in approximately 1:1000 pregnancies, appendiceal neuroendocrine neoplasm (ANEN) diagnosis during pregnancy is very rare. Data on presentation, treatment and prognosis is scarce.AimTo describe ANEN cases diagnosed during pregnancy.Materials and methodsA retrospective appraisal of 7 consecutive ANEN patients diagnosed during pregnancy from four Israeli tertiary medical centers and comparison with 17 cases described in the literature from 1965-2021.ResultsAge at ANEN diagnosis was 26.4 ± 3.5 years (range 21-33). Patients were diagnosed between gestational weeks 6-40, most frequently in the third trimester (53%). The most common presenting symptom was abdominal pain. Tumor size was 14.3 ± 8.9mm (range 3-45mm). In patients from our series appendiceal base involvement was reported in 2/7; mesoappendiceal invasion in 5/7; lympho-vascular invasion in 2/7. Ki67 staining was reported in 6/7 cases and ranged from 1-10%. Pathology details were lacking in most of the previously published cases. All 7 pregnancies in our series resulted in term delivery with no complications, whereas in historical cases there were one first trimester abortion, one ectopic pregnancy, and one stillbirth. Right hemicolectomy was performed in 5/7 patients in our series and reported in 2/17 historical cases. All hemicolectomies were performed after delivery, 3-16 months after appendectomy. Local metastases were reported in two cases. Follow-up duration was 7-98 months for our patients and 3-48 months in 5 historical cases. No disease recurrence, distant metastases or mortality were noted.ConclusionsTo the best of our knowledge, this is the largest series describing the extremely rare diagnosis of ANEN during pregnancy. Although pathologic characteristics varied, pregnancy outcomes were usually favorable and long-term prognosis was excellent. This data may suggest that a conservative approach to patients with ANEN diagnosis during pregnancy can be considered.

show abstract

Composite Criteria for Non‐Operative Management of Acute Non‐Complicated Appendicitis Result in Low Failure Rates

et al. 2021

View full text Add to dashboard Cite

Background The aim of this study is to investigate the outcomes of conservative management of non-complicated acute appendicitis (AA) using our unique institutional protocol, and to compare between these and the outcomes of operative management. Methods Patients admitted to our institution between March 2016 and October 2019 with non-complicated AA were grouped according to their initial management: non-operative versus surgical. Our unique protocol for non-operative management includes: pain \ 3 days; afebrile upon admission; non-gravid; WBC \15,000 (9 10 9 /L); CRP \ 5 mg/ dl; appendix diameter \ 1 cm; no appendicolith on imaging; no prior episode of AA; no history of Inflammatory Bowel Disease; no evidence of peritonitis on physical examination. The primary outcome measured was failure of non-surgical management during the index admission. Secondary outcomes included recurrence rate, readmissions, complications, length of antibiotic treatment and length of stay (LOS). Results A total of 695 patients were included, 436 in the operative group and 259 in the non-surgical treatment group. The mean follow-up time was 1004.9 ± 205.7 days. Patients initially treated conservatively rarely required surgery during their index admission (6.9%). Recurrence rate was 19.1% after a mean follow up of 33.4 months. The overall failure rate of conservative management was documented in 20.8% of the patients. The complication rate was higher in those treated with upfront surgery (1.6% vs. 0.4%, p \ 0.001). The overall LOS was not statistically different between the groups. Conclusions Our composite protocol for non-surgical management of non-complicated AA results in a low failure rate. A well calculated patient treatment allocation in non-complicated AA can advocate for wide-spread use of the conservative approach.

show abstract

Appendiceal tumor incidence and an in-depth look at appendiceal neuroendocrine neoplasm in a cohort of 8,162 appendectomies: Full dataset

Cited by 4 publications

References 2 publications

Clinical and pathologic characteristics of appendiceal neuroendocrine neoplasms diagnosed during pregnancy

Composite Criteria for Non‐Operative Management of Acute Non‐Complicated Appendicitis Result in Low Failure Rates

Contact Info

Product

Resources

About