Appendicitis: When there is more than meets the eye

Jarry, Julien; Shekher, Manu; Imperato, Marc; Michel, P.

doi:10.1016/j.clinre.2011.05.014

Cited by 9 publications

(15 citation statements)

References 7 publications

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“…A palpable mass may be present . The features most often described are those that overlap with Crohn’s disease, including granulomas, transmural inflammation, lymphoid hyperplasia, and ulceration/abscesses . In our cases, we found greater degrees of lymphoid hyperplasia and transmural inflammation in these appendices than are seen in patients with actual Crohn’s disease or interval appendectomies.…”

Section: Discussionsupporting

confidence: 49%

“…14,15,18 The features most often described are those that overlap with Crohn's disease, including granulomas, transmural inflammation, lymphoid hyperplasia, and ulceration/ abscesses. 3,13,16 In our cases, we found greater degrees of lymphoid hyperplasia and transmural inflammation in these appendices than are seen in patients with actual Crohn's disease or interval appendectomies. One of the distinguishing features of actinomycotic appendicitis may be the marked fibrosis, which can create concern for malignancy, and distinguishes this entity from yersiniosis.…”

Section: Discussionsupporting

confidence: 45%

“…In several reported cases of appendiceal actinomycosis, long‐term antibiotic therapy was initiated because of concerns for the development of abdominal actinomycosis . However, some of the cases we have encountered went undiagnosed until retrospective review, and there seem to have been no negative consequences for those patients.…”

Section: Discussionmentioning

confidence: 96%

“…Our cases presented as either chronic or acute appendicitis (in two patients, followed by antibiotic therapy and interval appendectomy), and, in eight of the cases, an appendiceal neoplasm was considered in the differential diagnosis on the basis of radiological and/or operative findings of a mass‐like enlargement of the appendix. Most reported patients with actinomycotic appendicitis also presented with acute or subacute appendicitis . A palpable mass may be present .…”

Section: Discussionmentioning

confidence: 99%

“…Most reported patients with actinomycotic appendicitis also presented with acute or subacute appendicitis. 3,[13][14][15][16][17] A palpable mass may be present. 14,15,18 The features most often described are those that overlap with Crohn's disease, including granulomas, transmural inflammation, lymphoid hyperplasia, and ulceration/ abscesses.…”

Section: Discussionmentioning

confidence: 99%

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Actinomyces in Crohn’s‐like appendicitis

Horváth¹,

Maryamchik

Miller

et al. 2019

Histopathology

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Aims Appendicitis with a Crohn’s‐like histological appearance generally raises concern for Crohn’s disease, Yersinia infection, and interval appendectomy. Actinomyces infection is a recognised cause of chronic appendicitis that can histologically mimic Crohn’s disease. Methods and results We report on 20 cases of appendicitis with Crohn’s‐like histological features that were due to Actinomyces. Most patients presented with acute or chronic abdominal pain. Imaging studies suggested a mass in five cases. Two patients had interval appendectomy. Histological features showed Crohn’s‐like appendicitis in 16 cases, with moderate to marked fibrosis and granulomas in seven cases. The other four cases had less consistent histological findings. None of the patients developed Crohn’s disease during the follow‐up interval (median, 37 months). Conclusions Actinomyces can be associated with Crohn’s‐like appendicitis with marked fibrosis, transmural inflammation, lymphoid hyperplasia, and granulomas.

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Section: Discussionsupporting

confidence: 49%