Appendicular and breast cancers in an old lady: a case report

Alharbi, Ahlam; Aboasamh, Ghaleb; Shafik, Yasmine

doi:10.1093/jscr/rjx251

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Multiple primary malignant neoplasms (MPMNs) are rare, with a reported incidence of 0.4% and 21% in the cancer population and a prevalence of 0.7% and 11% ( 1 ). Billroth initially proposed MPMN in 1889 ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…MPMNs whose interval between two primary cancers is within 6 months are called simultaneous MPMNs, whereas those with an interval of more than 6 months are called metachronous MPMNs. The incidence of double or triple carcinomas in patients with MPMNs is only 0.5% ( 1 ). The most common tumors in MPMN are found in the gastrointestinal tract, followed by the lung, head, and neck ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

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Synchronous multiple primary malignancies of clear cell renal cell carcinoma with sarcomatoid, thyroid carcinoma: a case report

Tan

Chen

et al. 2023

Front. Oncol.

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Multiple primary malignant neoplasms (MPMNs) are defined as the presence of two or more malignancies with different histologies in the same patient. MPMNs are rare, accounting for fewer than 4% of all tumor cases. Depending on the time interval between the diagnosis of the different malignancies, they are classified as either simultaneous or metachronous MPMNs, with simultaneous being rarer in MPMNs. Here, we present a 63-year-old female patient presenting with multiple primary renal and thyroid carcinomas and discuss the risk factors, treatment options, and prognosis of rare dual carcinomas. We focus on managing multidisciplinary teams and selecting individualized treatment options to deliver valuable treatment strategies to patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synchronous multiple primary malignancies of clear cell renal cell carcinoma with sarcomatoid, thyroid carcinoma: a case report

Tan

Chen

et al. 2023

Front. Oncol.

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Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer

et al. 2021

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Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

Luca

Frusone

Vergine

et al. 2019

In Vivo

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Multiple primary malignant neoplasms are multiple tumors with different pathogenetic origin. They may be synchronous or metachronous. The management of these conditions represents an interesting clinical scenario. A crucial aspect is the decision regarding which tumor to treat initially, and how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. We describe a case report of a female patient affected by primary synchronous tumors of the breast and pectoral skin, which raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature. Multiple primary malignant neoplasms (MPMNs), or multiple primary cancers, are defined as multiple tumors with different pathogenetic origin. The phenomenon of MPMN was first described by Billroth at the end of the 19th century (1) and since then several cases of double or even triple primary malignant neoplasms have been reported (1-3). Neoplasms can be synchronous or metachronous and may appear in a single organ or in multiple organs concurrently. According to Moertel (2), synchronous neoplasms are defined as those that occur within 6 months from the diagnosis of a previous malignant tumor, and metachronous neoplasms are defined as neoplasms that appear 6 months after the first diagnosed tumor (2). Despite many changes in the definition have been proposed, the diagnosis of MPMNs that is widely accepted is based on the criteria described by Warren and Gates (3). These criteria require that: (i) each tumor must have a clear picture and histological confirmation of malignancy; (ii) each tumor must be topographically distinct and separated by healthy mucosa (at least 2 cm of normal mucosa between two tumors of the same region); (iii) the lesions must be not metastases of each other (3). In this report, we describe our recent observation and treatment of a female patient affected by primary synchronous tumors of the breast and pectoral skin. This combination, to the best of our knowledge, has never been previously reported in the literature, and it raised a series of diagnostic, etiological and therapeutic issues persuading us to carry out a critical review of the literature.

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Appendicular and breast cancers in an old lady: a case report

Cited by 3 publications

References 6 publications

Synchronous multiple primary malignancies of clear cell renal cell carcinoma with sarcomatoid, thyroid carcinoma: a case report

Synchronous multiple primary malignancies of clear cell renal cell carcinoma with sarcomatoid, thyroid carcinoma: a case report

Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature

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