Appendicular fat mass is positively associated with femoral neck bone mineral density in older women

Marques, Elisa A.; Moreira, Pedro; Wanderley, Flávia Accioly Canuto; Pizarro, Andréia; Leão-Rosas, José P.; Mota, Jorge; Carvalho, Joana

doi:10.1097/gme.0b013e31822a8d51

Cited by 9 publications

(4 citation statements)

References 31 publications

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“…Depot-specific fat has been known to play a different role in terms of obesity and metabolism. A previous study indicated that different fat depots might have distinct relationships with bone mass;22 Marques et al reported AFM had a positive association with femoral neck BMD in older women 23. Inconsistent with that, several studies stated AFM had no24 or a negative25 relationship with BMD.…”

Section: Discussionmentioning

confidence: 98%

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

et al. 2020

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ObjectivesThis study was an attempt to investigate the variation trend of body composition with ageing and explore the association between regional body composition and bone mineral density (BMD).DesignCross-sectional study.Setting and participantsA total of 5749 healthy adults aged 20–95 years was recruited from 2004 to 2017.Primary outcome measuresWhole-body lean mass (LM), fat mass (FM), android FM, gynoid FM, appendicular lean mass (ALM) and BMD in the lumbar spine, femoral neck and total hip were obtained by dual-energy X-ray absorptiometry (DXA). The android/gynoid fat mass ratio (A/G FMR) based on DXA scan was calculated as an indicator of adipose distribution. Pearson correlation and multiple linear regression analyses were used to determine the associations between body composition, adipose distribution, and BMD of each skeletal site.ResultsWhole-body FM, percentage of whole-body FM, Android FM and A/G FMR consistently increased with age in both genders, especially in women, and ALM began to decrease in the fifth decade for both men and women. In multivariable linear regression models with age, body mass index, A/G FMR and ALM as predictor variables, ALM was associated with the most BMD variance of all skeletal sites in men (standard β ranged from 0.207 to 0.405, p<0.001), although not the largest but still a positive predictor of BMD in women (standard β ranged from 0.074 to 0.186, p<0.05). A/G FMR was an inverse predictor of BMD at all skeletal sites for women (standard β ranged from −249 to −0.052, p<0.01) but not in men.ConclusionsIn this large cohort of Chinese adults, ALM had a strong positive association with BMD in both genders. A/G FMR as an indicator of central adipose accumulation was inversely associated with BMD in women but not in men.

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Section: Discussionmentioning

confidence: 98%

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

et al. 2020

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“…Conversely, subcutaneous fat had a favorable effect on these bone parameters. A protective impact of subcutaneous fat on bone health (femoral neck BMD in elderly women) was also determined by Marquez et al [31]. On the other hand, Wang et al [32] failed to discern any detectable association between subcutaneous fat and lumbar spine BMD.…”

Section: Interactions Between Adipose Tissue and Bone Tissuementioning

confidence: 86%

Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target

Martiniakova,

Biro,

Penzes

et al. 2024

IJMS

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Obesity, type 2 diabetes mellitus (T2DM) and osteoporosis are serious diseases with an ever-increasing incidence that quite often coexist, especially in the elderly. Individuals with obesity and T2DM have impaired bone quality and an elevated risk of fragility fractures, despite higher and/or unchanged bone mineral density (BMD). The effect of obesity on fracture risk is site-specific, with reduced risk for several fractures (e.g., hip, pelvis, and wrist) and increased risk for others (e.g., humerus, ankle, upper leg, elbow, vertebrae, and rib). Patients with T2DM have a greater risk of hip, upper leg, foot, humerus, and total fractures. A chronic pro-inflammatory state, increased risk of falls, secondary complications, and pharmacotherapy can contribute to the pathophysiology of aforementioned fractures. Bisphosphonates and denosumab significantly reduced the risk of vertebral fractures in patients with both obesity and T2DM. Teriparatide significantly lowered non-vertebral fracture risk in T2DM subjects. It is important to recognize elevated fracture risk and osteoporosis in obese and T2DM patients, as they are currently considered low risk and tend to be underdiagnosed and undertreated. The implementation of better diagnostic tools, including trabecular bone score, lumbar spine BMD/body mass index (BMI) ratio, and microRNAs to predict bone fragility, could improve fracture prevention in this patient group.

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“…Studies have yielded con icting results. Several studies 38,39 , such as the Older Afro-Caribbean Men study and another study on older women, have found that higher amounts of SAT are associated with higher BMD, suggesting a protective effect on bone health. Subcutaneous fat may help with bone strength in healthy young women according to research by Vicente Gilsanz et al 16 However, a research on Chinese women did not discover a connection between SAT and BMD.…”

Section: Discussionmentioning

confidence: 99%

Relationship between visceral and subcutaneous fat and bone health in American adults: a cross-sectional study

Lin

Zhong

Yao

et al. 2023

Preprint

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Objective: The relationship between fat accumulation in visceral or subcutaneous tissue and bone mineral density (BMD) remains unclear. In this study, we aim to shed light on this relationship by examining a large, nationally representative population. Methods: A weighted multiple linear regression model was established to evaluate the relationship between visceral fat, subcutaneous fat and BMD. Additionally, the potential nonlinear relationship was explored using smooth curve fitting method. Results: A total of 10455 participants between the ages of 20 and 59 were included in this study. Various weighted multiple linear regression models revealed a negative correlation between lumbar BMD T-score and visceral mass index (VMI) and subcutaneous mass index (SMI). However, the association between VMI and lumbar BMD T-score was U-shaped when we did smooth curve fitting, and the inflection point of 0.304kg/m² was determined using a two-stage linear regression model. Conclusions: Subcutaneous fat and BMD T-score were found to have a negative association, and visceral fat and BMD T-score were discovered to have a U-shaped connection. It is the significance of taking body composition and weight control into account while treating and preventing osteoporosis.

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Appendicular fat mass is positively associated with femoral neck bone mineral density in older women

Abstract: These data highlight that in older women, localization of FM is more important for bone mass than obesity per se or lean mass. AFM (subcutaneous adiposity) seems to exhibit an independent protective effect on BMD.

Cited by 9 publications

References 31 publications

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study

Links among Obesity, Type 2 Diabetes Mellitus, and Osteoporosis: Bone as a Target

Relationship between visceral and subcutaneous fat and bone health in American adults: a cross-sectional study

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