Appetite-regulating Hormones in Chronic Kidney Disease Patients

Öner-İyidoğan, Yıldız; Gürdöl, Figen; Koçak, Hikmet; Öner, Pernur; Çetinalp-Demircan, Pınar; Çalışkan, Yaşar; Koçak, Taner; Türkmen, Aydın

doi:10.1053/j.jrn.2010.07.005

Cited by 38 publications

(27 citation statements)

References 38 publications

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“…Further, the levels of acyl ghrelin were lowest in the severe SGA category of malnutrition and in patients with poor appetite. It has been reported that low acyl ghrelin is associated with poor nutritional status, loss of appetite (Oner-Iyidogan et al 2011) and CVD (Chou et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

et al. 2013

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“…1 Anorexia is mediated by circulating appetite regulators, such as gastric hormones, that is ghrelin and obestatin. Acyl-ghrelin is considered to be ghrelin's active orexigenic form while obestatin, originates from the same acyl-ghrelin gene, seems to decrease appetite.…”

Section: Introductionmentioning

confidence: 99%

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

et al. 2015

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Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acylghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into two groups, 16 patients performed exercises and 9 patients comprised the control group. The patients performed the exercises in both lower limbs with ankle-cuffs and elastic bands, 30 min after the initiation of hemodialysis session. Blood samples of both the groups were drawn in the morning before and after 30 min with exercise session (exercise group) and, before and after the same time without exercise (control group). Acyl-ghrelin and obestatin plasma levels were measured using an enzyme immunometric assay. Acyl-ghrelin plasma levels did not change in both the groups. However, when stratified by gender the acyl-ghrelin increased significantly right after exercise in men [32.1 pg/mL (25.6-41.2) to 46.0 pg/mL (39.0-59.5)] (p ¼ 0.04). Obestatin plasma levels reduced after a single bout of exercise and changes remained significantly when the sample was stratified by gender. There was no change in obestatin plasma levels in control group. A single bout of resistance exercise seems to modulate the levels of appetite hormones in HD patients.

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“…It has been suggested that poor appetite may be due to higher serum concentration of middle molecules, to chronic inflammation and related high serum concentration of C-reactive protein and interleukin-6, and to lower serum levels of branched chain amino acids [4,5,6,7,8]. …”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of poor appetite in HD patients is only in part known [1,2,3]. It has been proposed that uremic toxins such as middle molecules, inflammation, altered pattern of amino acids, hormones and peptides may be involved [4,5,6,7,8]. Recently, we have shown that poor appetite is independently associated with gastrointestinal symptoms [9], fatigue [10] and symptoms of depression [11].…”

Section: Introductionmentioning

confidence: 99%

Appetite Is Associated with the Time of Recovery after the Dialytic Session in Patients on Chronic Hemodialysis

Bossola¹,

Tazza²

2013

Nephron Clin Pract

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Aim: The aim of this cross-sectional study was to assess the correlation between self-reported appetite and the time of recovery after the hemodialysis session (TIRD). Methods: All patients on chronic hemodialysis at the Hemodialysis Service of the Catholic University of Rome underwent assessment of appetite through the first three questions of the Hemodialysis Study Appetite questionnaire, TIRD (through the question ‘How long does it take you to recover from a dialysis session?'), number and severity of comorbidities according to the Charlson Comorbidity Index (CCI), and daily activities through the ADL (activities of daily living) and the IADL (instrumental activities of daily living). Results: We studied 106 patients. According to the appetite questionnaire, in 45 patients appetite was very good or good (group 1), in 33 fair (group 2) and in 28 poor or very poor (group 3). Age, CCI, TIRD and serum parathyroid hormone levels were significantly higher in group 3 than in groups 1 and 2, while the IADL was significantly lower. Age, CCI, TIRD, IADL and serum parathyroid hormone were significantly correlated with appetite. At multiple regression analysis, TIRD and CCI only were independently correlated with appetite. Conclusion: Poor appetite is independently associated with the time of recovery after the hemodialysis session.

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Appetite-regulating Hormones in Chronic Kidney Disease Patients

Cited by 38 publications

References 38 publications

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Appetite Is Associated with the Time of Recovery after the Dialytic Session in Patients on Chronic Hemodialysis

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