Apple cider vinegar attenuates lipopolysaccharide-induced neurobehavioral deficits in mice

Asejeje, Folake Olubukola; Abiola, Michael Abayomi; Ben‐Azu, Benneth; Adeosun, Abiola Muhammad; Ighodaro, Osasenaga Macdonald; Ajayi, Abayomi Mayowa

doi:10.1186/s41110-020-00125-1

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…The finding that Golden Delicious vinegar alleviated depressive-like behaviors by reducing the time of immobility may suggest its beneficial effect in depression-related conditions through a possible increase in the serotonergic system. The same conclusion has been reported in the study conducted by Asejeje et al, confirming that the administration of apple vinegar reduced attenuated lipopolysaccharide-induced anxiety and depressionlike behaviors in mice via possible involvement of the serotonergic system [48]. The same investigation found that apple vinegar effectively prevented a lipopolysaccharideinduced increase in levels of brain proinflammatory cytokines levels (IL-6 and TNF-α) and, consequently, the alleviation of depression-like behaviors in mice.…”

Section: Antidepressant Activitysupporting

confidence: 83%

“…In this context, significant inhibition of the activity of cyclooxygenase-1 by acetic acid (the main organic acid of apple vinegar) has been experimentally proven; consequently, it has an influence on the disruption of the synthesis of prostaglandin via the arachidonic acid pathway [47]. Moreover, the anti-inflammatory activity of apple vinegar and acetic acid and its inhibitory effects on pro-inflammatory cytokines such as TNFα and IL-6 have also been proven by various anti-inflammatory tests in vivo and in vitro, [6,48]. Further mechanistic investigation showed that vinegar and acetic acid reduce ulcerative colitis inflammation in mice by inhibiting Th1 and Th17 responses, NLRP3 inflammasome, and activation of MAPK signaling [49].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Exploring the Bioactive Compounds in Some Apple Vinegar Samples and Their Biological Activities

El Abdali,

Saghrouchni,

Kara

et al. 2023

Plants

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Apple vinegar is highly recommended for nutrition due to its health benefits and bioactive components. However, the apple cultivar greatly influences the quality of the vinegar. In this research, our focus was on examining the impact of four different apple cultivars on the physicochemical attributes, chemical composition, as well as biological properties—including antidepressant and anti-inflammatory activities—of vinegar. Interestingly, the physicochemical properties of vinegar and the contents of acetic acid and polyphenols depend on the apple cultivars. HPLC chromatographic analysis showed that citric acid (820.62–193.63 mg/100 g) and gallic acid (285.70–54.40 µg/g) were mostly abundant in the vinegar samples. The in vivo results showed that administration of Golden Delicious apple vinegar (10 mL/kg) to adult Wistar rats reduced carrageenan-induced inflammation by 37.50%. The same vinegar sample exhibited a significant antidepressant effect by reducing the rats’ immobility time by 31.07% in the forced swimming test. Due to its high acidity, Golden Delicious vinegar was found to be more effective against bacteria, particularly Bacillus subtilis and Candida albicans, resulting in a MIC value of 31.81 mg/mL. Furthermore, the antioxidant activity of various vinegar samples was found to be powerful, displaying optimal values of IC50 = 65.20 mg/mL, 85.83%, and 26.45 AAE/g in the DPPH, β-carotene decolorization and TAC assays, respectively. In conclusion, the apple cultivars used in this study impact the chemical composition and biological activities of vinegar, which may help demonstrate the importance of raw material selection for the production of vinegar.

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Section: Antidepressant Activitysupporting

confidence: 83%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Exploring the Bioactive Compounds in Some Apple Vinegar Samples and Their Biological Activities

El Abdali,

Saghrouchni,

Kara

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…It has been reported that polyphenolic compounds act can reduce the free radicals (9). Un ltered apple cider vinegar includes the "mother," which is a colony of bene cial probiotic bacteria such as lactobacillus serotypes, which have a major role in the improvement of the gut and immune system function, anti-in ammation effects and immune system booster (10) (11).…”

Section: Introductionmentioning

confidence: 99%

Using D.SAP, an apple-based formulation for treatment of human papilloma virus, a case report

Dezhakam,

Dezhakam

et al. 2024

Preprint

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The Human papilloma virus (HPV) with almost 1% of prevalence in sexually active adults has more than thirty-five (HPV) types, that can infect the genital tract in women and cause a visible genital HPV infection and genital warts that reveal on the cervix, vagina, urethra, anus, and surrounding areas are mostly caused by HPV genotypes 6, 11 and 18. Moreover, the oncogenic HPV types including 16,18,31,33 and 35 are detected in most of the genital warts and are significantly associated with intraepithelial neoplasia of vulval (VIN), cervical (CIN), and anal (AIN). About fifty percent of the infected group have a subclinical or latent infection. Some of the HPV types can cause cervical, vaginal, and vulvar cancers. The most common treatment methods for removal of the HPV-induced vaginal warts are including cryotherapy, electrocautery, laser therapy, surgery, or trichloroacetic acid. In the present case report the treatment of a 41 years old woman with HPV infection and HPV-induced vaginal warts using an Iranian specially formulated apple-based sap called Dezhakam sap (D.SAP) has been presented. Results showed the disappearance of warts on the vaginal area, and replacement with normal tissue after three months of treatment. D.SAP is an antioxidant and probiotic-rich compound that could help the immune system fight against HPV infections and may present as a potential complementary therapy for HPV-induced warts.

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Synergistic Amelioration of Letrozole-induced Polycystic Ovary Syndrome in Rats: A Therapeutic Approach with Apple Cider Vinegar and Metformin Combination

Danduga,

Kurapati,

Shaik

et al. 2024

Reprod. Sci.

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Apple cider vinegar attenuates lipopolysaccharide-induced neurobehavioral deficits in mice

Cited by 5 publications

References 39 publications

Exploring the Bioactive Compounds in Some Apple Vinegar Samples and Their Biological Activities

Exploring the Bioactive Compounds in Some Apple Vinegar Samples and Their Biological Activities

Using D.SAP, an apple-based formulation for treatment of human papilloma virus, a case report

Synergistic Amelioration of Letrozole-induced Polycystic Ovary Syndrome in Rats: A Therapeutic Approach with Apple Cider Vinegar and Metformin Combination

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