Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats

Mahmoud, Mona F.; Abdo, Walied; Nabil, Mohamed; Drissi, Badreddine; El-Shazly, Assem M.; Abdelfattah, Mohamed A.O.; Sobeh, Mansour

doi:10.1016/j.biopha.2023.114331

Cited by 21 publications

(10 citation statements)

References 37 publications

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“…It has been reported that NSAIDs exert side effects by inducing cell damage directly [ 51 ]. The main mechanism of indomethacin-induced gastric ulcer is related to inhibition of cyclooxygenase (COX)-1, leading to a reduction of gastric mucosal PG synthesis [ 48 , 52 ]. The gastric mucosal damage caused by indomethacin is also associated with the decrease in biosynthesis of nitric oxide (NO), which is known as a defensive factor of the gastrointestinal tract [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…The gastric mucosal damage caused by indomethacin is also associated with the decrease in biosynthesis of nitric oxide (NO), which is known as a defensive factor of the gastrointestinal tract [ 53 ]. In addition, many previous studies reported that oxidative stress and ROS are also involved in the pathogenesis of indomethacin-induced gastric ulcer [ 48 , 52 , 53 ]. In this study, the ulcer indexes of the TS-treated groups were significantly lower than the control group, and the anti-gastric ulcer activity of TS at the high dose (600 mg/kg) was approximately equivalent to that of the reference group which received misoprostol.…”

Section: Discussionmentioning

confidence: 99%

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Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Tan,

Chiranthanut,

Chansakaow

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Tan,

Chiranthanut,

Chansakaow

et al. 2023

Heliyon

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“…A C18 reverse phase column (Zorbax Eclipse XDB-C18, fast resolution, 4.6 × 150 mm, 3.5 μm, Agilent, USA) was used for the separation process. The mobile phase and the mass spectrometry conditions were set according to the previously described method ( 14 ). Ions were detected in negative mode using a full scan mode within a mass range of 100–1500 m/z ( Supplementary material ).…”

Section: Methodsmentioning

confidence: 99%

Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties

Drissi,

Mahdi,

Ortaakarsu

et al. 2024

Front. Nutr.

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IntroductionCubeb, Piper cubeba L., has been used for centuries in traditional medicine and culinary practices, with a wide range of biological and pharmacological activities.ObjectiveHerein, we determined the phytochemical profile, mineral, fatty acids, and amino acid contents of P. cubeba berries and assessed the dermacosmeceutical properties of their water extract and essential oil (EO). These included assessing their antioxidant and antibacterial activities as well as their in vitro inhibitory activities against tyrosinase and elastase enzymes. In addition, molecular docking and molecular dynamics studies were performed on the major identified compounds of the EO.Results and discussionA total of forty-three compounds belonging to organic acids, phenolic acids and flavonoids were found in the water extract, while 36 volatile compounds were identified in the EO with Z-isoeugenol, dihydroeugenol, β-pinene, E-caryophyllene, and 1,8-cineole as major constituents. The berries were found to be rich in sodium and iron, have moderate zinc content along with low contents of total nitrogen, phosphorus, and potassium. Amino acid analysis revealed a considerable concentration of isoleucine and phenylalanine, whereas 11,14,17-eicosatrienoic acid and linoleic acid were identified as the major fatty acids. In the DPPH and FRAP assays, the water extract elicited considerable antioxidant activity compared to the reference compounds. Enzyme inhibitory assays revealed that the EO had a potential to inhibit tyrosinase and elastase enzymes with IC50 values of 340.56 and 86.04 μg/mL, respectively. The water extract and EO completely inhibited the bacterial growth at MIC of 50 mg/mL and 20%, respectively. At sub-MIC concentrations, the extract and the EO substantially reduced the biofilm formation by up to 26.63 and 77.77%, respectively, as well as the swimming and swarming motilities in a dose-dependent manner. Molecular docking and molecular dynamics showed that the five main components of P. cubeba EO could be the major contributors to the elastase and tyrosinase inhibitory effect.ConclusionThis study emphasizes the promising potential of P. cubeba as a valuable source of natural compounds that can be utilized for the development of innovative pharmaceuticals, dietary supplements, and dermacosmeceutical agents.

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“…Medicinal Aromatic Plants (MAPs) are therapeutic for many diseases and have not been su ciently explored to provide scienti c evidence of their claimed biological activity. It is necessary to reveal their potential by chemical analysis of the constituents of MAPs, determining their biological, pharmacological and toxic effects [2,3] Studies on many plants related to alternative medicine have been reported to be generally protective [4,5]. It has been reported that leaves, tubers, owers and ower buds of Muscari species are consumed raw and cooked and used as a gastricic, expectorant, wart treatment, urine enhancer [6].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of water extract of Muscari neglectum on indomethacin-induced gastric ulcer in rats

Soydan,

Arabaci,

Utlu

et al. 2024

Preprint

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Muscari Mill. is used raw and cooked for gastric diseases, expectorants, wart treatment, and urine enhancers. No scientific study has been found on the effect of Muscari neglectum (MN) water extract on stomach diseases. Here, the effect of water extract of MN plant on some biochemical and histopathological parameters on indomethacin-induced gastric ulcer in rats was examined. In this study, 60 male Sprague Dawley rats were used for 24 acute toxicity and 36 gastric ulcer models (n = 6). They were divided into 6 groups as intact; indomethacin, famotidine, indomethacin and MN (100, 200, 400 mg/kg). The results of the gastric tissues examined biochemically, macroscopically and histopathologically showed that all doses of MN extracts prevented indomethacin-induced gastric mucosal damage and the 400 mg/kg dose had the strongest antiulcer effect with 69%. When SOD, GSH, CAT and MDA levels were investigated, the indomethacin-induced gastric ulcer group had a decrease in SOD, CAT and GSH levels and an increase in MDA levels. Additionally, LC-MS/MS analysis of the water extract of MN was performed and 14 phenolic compounds were determined. Biochemical analyses and histopathological examinations revealed that the water extract of MN has a good protective effect against gastric ulcer due to its high antioxidant content.

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Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats

Cited by 21 publications

References 37 publications

Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties

Gastroprotective effect of water extract of Muscari neglectum on indomethacin-induced gastric ulcer in rats

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