Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis

Li, Yuhua; Wang, Sheng; Sun, Yang; Xu, Wenqi; Zheng, Hongnan; Wang, Yan; Tang, Yuan; Gao, Xiaowei; Song, Can; Yin, Long; Liu, Jiayun; Liu, Li; Mei, Qibing

doi:10.1016/j.carbpol.2019.115726

Cited by 49 publications

(21 citation statements)

References 33 publications

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“…A dynamic micro-ecosystem that has an important role to play in CAC prevention is the gut microbiota. Decreased diversity and richness often occur in CAC ( Li C. et al., 2020 ). While many studies back up the idea that a low Firmicutes/Bacteroides (F/B) ratio suggests good health, the F/B value of mice in the DSS community, however, is relatively poor, according to recent research ( Liu et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

Zhu

Jia

Fan

et al. 2021

Front. Cell. Infect. Microbiol.

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Hunting for natural compounds that can modulate the structure of the intestinal flora is a new hotspot for colitis‐associated cancer (CAC) prevention or treatment. Alisol B 23-acetate (AB23A) is a natural tetracyclic triterpenoid found in Alismatis rhizoma which is well known for dietary herb. Alismatis rhizoma is often used clinically to treat gastrointestinal diseases in China. In this study, we investigated the potential prevention of AB23A in male mouse models of azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced CAC. AB23A intervention alleviated the body weight loss, disease activity index, colon tumor load, tissue injury, and inflammatory cytokine changes in CAC mice. AB23A intervention leads to remarkable reductions in the activation of TLR, NF-κB and MAPK. AB23A significantly decreased the phosphorylation of p38, ERK, and JNK and up-regulated mucin-2 and the expression of tight junction proteins. The gut microbiota of AB23A-interfered mice was characterized with high microbial diversity, the reduced expansion of pathogenic bacteria, such as Klebsiella, Citrobacter, and Akkermansia, and the increased growth of bacteria including Bacteroides, Lactobacillus, and Alloprevotella. These data reveal that AB23A has the potential to be used to treat CAC in the future.

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Section: Discussionmentioning

confidence: 99%

Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

Zhu

Jia

Fan

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Finally, the library was sequenced on the Ion S5TM XL platform (Thermo Fisher Scientific, United States). For the bioinformatics analysis, the data processing was followed as previously reported protocol [ 9 , 10 ]. Briefly, the raw fast files were filtered using Cutadapt (V1.9.1).…”

Section: Methodsmentioning

confidence: 99%

Adiponectin Deficiency Suppresses Rhabdomyosarcoma Associated with Gut Microbiota Regulation

Jiao

Wang

Huang

et al. 2021

BioMed Research International

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The gut microbiota is very important in the initiation, progression, and dissemination of cancer, and the regulation of microbiota has been employed as a novel strategy to enhance the effect of immunotherapy. Adiponectin (APN), an adipocyte-derived hormone, plays a vital role in regulating the immune response of innate immune cells. The deficiency of APN inhibits rhabdomyosarcoma growth. However, whether this function is associated with regulating gut microbiota remains unknown. To investigate, we performed 16S ribosomal RNA (rRNA) gene sequencing on the fecal microbiome of APN gene knockout mice to determine whether APN deletion affects the gut microbiota. We found APN deficiency alters gut microbial functions involved in metabolism, genetic information processing, and cellular processes. In addition, a decreased abundance of Bacteroides and an increased abundance of Prevotella and Helicobacter were observed in rhabdomyosarcoma-bearing APN knockout mice; these bacteria were associated with the inhibition of rhabdomyosarcoma growth. These findings suggest that gut microbiota may be a potential target of APN deficiency against rhabdomyosarcoma.

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“…Ritonavir/ lopinavir which inhibits the 3CL pro , PL pro activity and replication of the virus did not significantly accelerate the clinical improvement in the patients with COVID-19 (Cao et al, 2020). Favipiravir is an antiviral drug that inhibits viral RdRp, umifenovir (arbidol), can prevent S protein /ACE2 interaction and inhibits membrane fusion of viral envelope (Huang et al, 2020). Many other potential therapeutic compounds are in the pipeline of clinical investigation around the world.…”

Section: Treatments Of Covid-19mentioning

confidence: 99%

“…The disease is complicated by the antagonistic effects on lower respiratory tracts further developing pneumonia in humans (Sohrabi et al, 2020) older ones and those with pre-existing cardiovascular or respiratory disorders are at higher risk for serious complications like severe pneumonia, acute respiratory syndrome, multiple organ failure, and in some cases death (Zhu et al, 2020). World Health Organization (WHO) declared it as a pandemic on 11 March 2020 due to a rapid increase in the number of cases outside of China (Huang et al, 2020). According to John Hopkin's coronavirus resource center, SARS-CoV-2 had infected 17,053,700 people across the world and killed 667,693 people worldwide by July 30, 2020 (Home -Johns Hopkins Coronavirus Resource Center, n.d.).…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Secondary Metabolites as Potential Mediators against COVID-19: A Review

et al. 2020

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The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has envisioned a global health concern. The scientists and physicians around the world have been racing to understand the pathophysiology and possible treatment régimes to discover an effective therapeutic resolution against the disease. Different secondary metabolites from plants exhibit substantial biological assets including antiviral activity. These compounds may be used against the infections of coronavirus. The research papers, reviews, and preprints were searched from the PubMed database using keywords like severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and traditional herbal medicine against COVID-19. The review focuses on those natural products which exhibited optimistic results against SARS-COV and SARS-CoV-2 in virtual as well as physical in vitro and in vivo tests. It summarizes the epidemiological characters, pathogenesis, structure, and targeting strategies of the virus. The compounds like lycorine, psoralidin, quercetin, glycyrrhizin, baicalin, caffeic acid, etc. could be the leads for the drug development against COVID-19.

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Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis

Cited by 49 publications

References 33 publications

Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

Adiponectin Deficiency Suppresses Rhabdomyosarcoma Associated with Gut Microbiota Regulation

Plant-Derived Secondary Metabolites as Potential Mediators against COVID-19: A Review

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