Applicability assessment of a stent-retriever thrombectomy finite-element model

Luraghi, Giulia; Matas, José Félix Rodríguez; Dubini, Gabriele; Berti, Francesca; Bridio, Sara; Duffy, Sharon; Dwivedi, Anushree; McCarthy, Ray; Fereidoonnezhad, Behrooz; McGarry, Patrick; Majoie, Charles B. L. M.; Migliavacca, Francesco; investigators, Insist

doi:10.1098/rsfs.2019.0123

Cited by 48 publications

(66 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, our model predictions suggests that (i) blood clots transition from a low constant stiffness regime at low strains to a high constant stiffness regime at high strains, rather than exhibiting continuous power-law or exponential strain stiffening; (ii) blood clots exhibit a volumetric strain stiffening, and traditionally implemented single parameter (bulk modulus) linear volumetric constitutive laws (Fereidoonnezhad et al 2016(Fereidoonnezhad et al , 2017Nolan and McGarry 2016;Rouhani et al 2019) are not suitable for the simulation of large multiaxial large-deformation of clots. This for in silico thrombectomy simulations (Luraghi et al 2021) .…”

Section: Discussionmentioning

confidence: 99%

“…8B) with a pressure P 0 = 75 mmHg applied to the proximal face of the clot to approximate in-vivo physiological loading. as thrombectomy and aspiration (Luraghi et al 2021) to provide improved predictions of the interaction between the clot and the intervention device and may also provide improved prediction of clot fragmentation risk during thrombectomy procedures. For example the maximum principal stress in this simulation is lower than the critical value for clot fracture recently determined by the authors (Fereidoonnezhad et al 2020a).…”

Section: Simulation Of In-vivo Patient Specific Clot Occlusionmentioning

confidence: 99%

See 1 more Smart Citation

A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels

Fereidoonnezhad

Moerman

Johnson

et al. 2021

Biomech Model Mechanobiol

Self Cite

View full text Add to dashboard Cite

Mechanical thrombectomy can be significantly affected by the mechanical properties of the occluding thrombus. In this study we provide the first characterization of the volumetric behaviour of blood clots. We propose a new hyperelastic model for the volumetric and isochoric deformation of clot. We demonstrate that the proposed model provides significant improvements over established models in terms of accurate prediction of nonlinear stress-strain and volumetric behaviours of clots with low and high red blood cell compositions. We perform a rigorous investigation of the factors that govern clot occlusion of a tapered vessel. The motivation for such an analysis is two-fold: (i) the role of clot composition on the in-vivo occlusion location is an open clinical question that has significant implications for thrombectomy procedures; (ii) invitro measurement of occlusion location in an engineered tapered tube can be used as a quick and simple methodology to assess the mechanical properties/compositions of clots. Simulations demonstrate that both isochoric and volumetric behaviour of clots are key determinants of clot lodgement location, in addition to clot-vessel friction. The proposed formulation is shown to provide accurate predictions of in-vitro measurement of clot occlusion location in a silicone tapered vessel, in addition to accurately predicting the deformed shape of the clot.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Simulation Of In-vivo Patient Specific Clot Occlusionmentioning

confidence: 99%

A new compressible hyperelastic model for the multi-axial deformation of blood clot occlusions in vessels

Fereidoonnezhad

Moerman

Johnson

et al. 2021

Biomech Model Mechanobiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our simulation of clot occlusion in patient-specific vessel provides a quantitative distribution of stress throughout the clot when lodged in the vessel. This can be used as an initial condition for in silico thrombectomy simulations (Luraghi et al 2021) .…”

Section: Discussionmentioning

confidence: 99%

“…This simulation highlights the significant deformation and stress in the clot at its occluded location. Such predicted stress distributions could be included in FE simulations of clinical interventions, such as thrombectomy and aspiration (Luraghi et al 2021) to provide improved predictions of the interaction between the clot and the intervention device and may also provide improved prediction of clot fragmentation risk during thrombectomy procedures. For example the maximum principal stress in this simulation is lower than the critical value for clot fracture recently determined by the authors (Fereidoonnezhad et al 2020a).…”

Section: Simulation Of In-vivo Patient Specific Clot Occlusionmentioning

confidence: 99%

A new compressible hyperelastic model for the multi-axial deformation of blood clots occlusion in vessels

Fereidoonnezhad¹,

Moerman²,

Johnson³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Mechanical thrombectomy can be significantly affected by the mechanical properties of the occluding thrombus. In this study we provide the first characterization of the volumetric behaviour of blood clots. We propose a new hyperelastic model for the volumetric and isochoric deformation of clot. We demonstrate that the proposed model provides significant improvements over established models in terms of accurate prediction of nonlinear stress-strain and volumetric behaviours of low and high haematocrit clots. We perform a rigorous investigation of the factors that govern clot occlusion of a tapered vessel. The motivation for such an analysis is two-fold: (i) the role of clot composition on the in-vivo occlusion location is an open clinical question that has significant implications for thrombectomy procedures; (ii) in-vitro measurement of occlusion location in an engineered tapered tube can be used as a quick and simple methodology to assess the mechanical properties/compositions of clots. Simulations demonstrate that both isochoric and volumetric behaviour of clots are key determinants of clot lodgement location, in addition to clot-vessel friction. The proposed formulation is shown to provide accurate predictions of in-vitro measurement of clot occlusion location in a silicone tapered vessel, in addition to accurately predicting the deformed shape of the clot.

show abstract

“…In silico methods can be used to not only predict the impact of a condition such as acute ischaemic stroke on an individual but also to assess the viability of treatment options. The study presented by Luraghi et al [24] demonstrates the significant advances being made in this latter direction. They develop a three-dimensional finite-element model to replicate the four stages of a stent-retriever thrombectomy and compare their in silico results to in vitro tests conducted in benchtop experiments.…”

mentioning

confidence: 99%