Traditionally, early warning systems for food safety are based on monitoring targeted food safety hazards. Therefore, food safety risks are generally detected only when the problems have developed too far to allow preventive measures. Successful early warning systems should identify signals that precede the development of a food safety risk. Moreover, such signals could be identified in factors from domains adjacent to the food supply chain, so-called drivers of change and other indicators. In this study, we show for the first time, using the dairy supply chain as an application case, that such drivers and indicators may indeed represent signals that precede the detection of a food safety risk. Using dynamic unsupervised anomaly detection models, anomalies were detected in indicator data expected by domain experts to impact the development of food safety risks in milk. Detrended cross-correlation analysis was used to demonstrate that anomalies in various indicators preceded reports of contaminated milk. Lag times of more than 12 months were observed. Similar results were observed for the 6 largest milk-producing countries in Europe (i.e., Germany, France, Italy, the Netherlands, Poland, and the United Kingdom). Additionally, a Bayesian network was used to identify the food safety hazards associated with an anomaly for the Netherlands.These results suggest that severe changes in domains adjacent to the food supply chain may trigger the development of food safety problems that become visible many months later.Awareness of such relationships will provide the opportunity for food producers or inspectors to take timely measures to prevent food safety problems. A fully automated system for data collection, processing, analysis and warning, such as that presented in this study, may further support the uptake of such an approach.