Objective: To determine the most reliable mixed dentition analysis method for Nalgonda population. Materials and Methods: This study was conducted on 60 boys and 60 girls of Nalgonda population, in the age group of 13-16 years. The mesiodistal and buccolingual dimensions of the permanent incisors, canines, premolars, and 1 st permanent molars were measured on the study models of all the subjects. Seven different mixed dentition analyses were performed which include Bachmann's, Gross and Hassund's, Trankmann et al., Camilo et al., Legovic et al., Tanaka-Johnston and Moyer's methods and were later compared. The Pearson's Correlation coefficients were calculated between the sums of the mesiodistal diameters (MDDs) of permanent canine, and premolars as measured on the study models and the predicted MDDs of the same using each of these seven methods. Results: The correlation coefficient r was highest for Moyer's mixed dentition analysis with a value of 0.957 and 0.979 in the mandibular and maxillary arch respectively for boys and 0.935 and 0.946 in the mandibular and maxillary arch respectively for girls. Conclusion: Moyer's mixed dentition analysis was found to be the most reliable method for both boys and girls of Nalgonda population of all the 7 methods compared.