Applicability of Single Muscle CSA for Predicting Segmental Muscle Volume in Young Men

Tanaka, Noriko; Kanehisa, Hiroaki

doi:10.1055/s-0033-1351251

Cited by 18 publications

(7 citation statements)

References 21 publications

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“…In addition, the manual assessment of whole-body organ and tissue volumes is time consuming. Alternatively, a number of authors replaced whole-body MRI by selected scans to assess SM or AT (3)(4)(5)(6)(7)(8)(9), which resulted in different slice locations for each tissue. To our knowledge, no study has investigated one common measurement site to assess SM and AT from a single MRI slice, which would be an enormous progress for the assessment of, for example, sarcopenic obesity.…”

Section: Introductionmentioning

confidence: 99%

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

Schweitzer

Geisler

Pourhassan

et al. 2015

The American Journal of Clinical Nutrition

244

169

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Background: Whole-body magnetic resonance imaging (MRI) is the gold standard for the assessment of skeletal muscle (SM) and adipose tissue volumes. It is unclear whether single-slice estimates can replace whole-body data. Objective: We evaluated the accuracy of the best single lumbar and midthigh MRI slice to assess whole-body SM, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Design: Whole-body MRI was performed in 142 healthy adults aged 19-65 y [mean 6 SD age: 37.0 6 11.8 y; BMI (in kg/m 2 ): 25.3 6 5.9]. Single slices were taken at lumbar vertebrae L1-L5 plus intervertebral discs and the thigh (midthigh, 10 cm distally from the midthigh, and 10 cm proximally from the midthigh). The value of single-slice areas was also tested in a longitudinal study on 48 healthy volunteers during weight loss (8.2 6 5.2 kg). Results: Cross-sectionally, all SM and adipose tissue single-slice areas correlated with total tissue volumes (P , 0.01). Because of the close associations between L3 areas and corresponding tissue volumes (r = 0.832-0.986, P , 0.01), this location was identified as the reference to estimate SM and adipose tissue in both sexes. SM, SAT, and VAT areas at L3 explained most of the variance of total tissue volumes (69-97%, with SEs of estimation of 1.96 and 2.03 L for SM, 0.23 and 0.61 L for VAT, and 4.44 and 2.47 L for SAT for men and women, respectively. There was no major effect on the explained variance compared with that for optimal slices. For SM, the optimal slice area was shown at midthigh. With weight-loss changes in total SM, VAT, and SAT, volumes were significantly different from those at baseline (SM changes: 22.8 6 2.9 L; VAT changes: 20.7 6 1.0 L; SAT changes: 25.1 6 6.0 L). The area at L3 reflected changes in total VAT and SAT. To assess changes in total SM volumes, areas at midthigh showed the best evidence. Conclusion: In both sexes, a single MRI scan at the level of L3 is the best compromise site to assess total tissue volumes of SM, VAT, and SAT. By contrast, L3 does not predict changes in tissue components. This trial was registered at clinicaltrials.gov as NCT01737034.Am J Clin Nutr 2015;102:58-65.

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Section: Introductionmentioning

confidence: 99%

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

Schweitzer

Geisler

Pourhassan

et al. 2015

The American Journal of Clinical Nutrition

244

169

View full text Add to dashboard Cite

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“…This is an improvement over manually segmented representative CSA, as segmenting full volumes is time-consuming without automatic tools [ 13 , 55 ]. The performance of CSA to predict muscle has shown disparate results, with some studies releasing a volume error of less than 10% [ 56 ] and others showing unacceptable results [ 57 ]. It seems that the accuracy of CSA as a predictor of whole muscle volume may depend on the body part under study [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Imaging Biomarkers in the Assessment of Sarcopenia

et al. 2020

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Background: The diagnosis of sarcopenia through clinical assessment has some limitations. The literature advises studies that include objective markers along with clinical assessment in order to improve the sensitivity and specificity of current diagnostic criteria. The decrease of muscle quality precedes the loss of quantity, so we studied the role magnetic resonance imaging biomarkers as indicators of the quantity and quality of muscle in sarcopenia patients. Methods: a cross-sectional analysis was performed to analyze what MR-derived imaging parameters correlate better with sarcopenia diagnostic criteria in women of 70 years of age and over (independent walking and community-dwelling women who were sarcopenic in accordance with EWGSOP criteria with muscle mass adjusted to Spanish population were chosen). Results: The study included 26 women; 81 ± 8 years old. A strong correlation was obtained between cineanthropometric variables (BMI; thigh perimeter and fat mass) and imaging biomarkers (muscle/fat ratio, fatty infiltration, muscle T2*, water diffusion coefficient, and proton density fat fraction) with coefficients around 0.7 (absolute value). Conclusions: Knowing the correlation of clinical parameters and imaging-derived muscle quality indicators can help to identify older women at risk of developing sarcopenia at an early stage. This may allow taking preventive actions to decrease disability, morbidity, and mortality in sarcopenia patients.

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“…In normal muscle or when disease affects homogeneously the muscle, cross-sectional areas measured at well-selected levels, f.i. mid-distance of the thigh, will provide pertinent trophicity indices [110,183,234] while considerably shortening acquisition and post-processing steps. However, this approach implies rigorous positioning relative to anatomical landmarks.…”

Section: Skeletal Muscle Trophicitymentioning

confidence: 99%

Novel Dominant Mutation in BIN1 Gene Causing Mild Centronuclear Myopathy Revealed by Myalgias and CK Elevation

Garibaldi

Böhm

Fattori

et al. 2016

Journal of Neuromuscular Diseases

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We present the clinical, morphological and molecular data of an Italian family with centronuclear myopathy, carrying a novel pathogenic mutation of BIN1 gene in heterozygous state, consistent with autosomal dominant inheritance. The proband, a 56-years-old man suffered of lower limbs myalgia and slight CK elevation. Clinical examination revealed no muscle weakness, short stature, mild symmetric eyelid ptosis, scapular winging, ankle retraction and well-developed muscles. Muscle biopsy showed nuclear centralization and clustering, deep sarcolemmal invaginations and type 1 fibers hypotrophy. Muscle MRI revealed fatty infiltration of posterior legs compartments, lumbar paraspinal and serratus muscles. By sequencing BIN1, we identified a heterozygous pathogenic mutation [c.107C>A (p.A36E)], and we demonstrate that the mutation strongly impairs the membrane tubulation property of the protein. One affected sister with similar phenotype carried the same mutation. Our findings expand the clinical, morphological and genetic spectrum of the autosomal dominant CNM associated with BIN1 mutations.

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Applicability of Single Muscle CSA for Predicting Segmental Muscle Volume in Young Men

Cited by 18 publications

References 21 publications

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

The Role of Imaging Biomarkers in the Assessment of Sarcopenia

Novel Dominant Mutation in BIN1 Gene Causing Mild Centronuclear Myopathy Revealed by Myalgias and CK Elevation

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