Liquefaction of clean and silty sands remains to be an important problem during earthquakes. Even though many factors are known to influence liquefaction behavior, the influence of density index parameter and fines content (FC) are among the most important parameters. In this study, the effect of relative density (Dr) on liquefaction behavior of clean and silty sands was investigated by cyclic direct simple shear tests on two different silty sands at various FC. Several different relationships affected from Dr are revisited or investigated including number of cycles to liquefaction (NL) and cyclic resistance ratio (CRR). It was found that liquefaction resistance-fines content-relative density relationship is much more complex than previously thought. This is because CRR-Dr lines of clean and/or silty sands may cross each other at specific relative densities, which may cause the liquefaction resistance of a clean sand to be either smaller, equal or greater than the liquefaction resistance of a silty sand with the same base sand dependent on the magnitude of relative density. The mentioned behavior is also confirmed on different clean and silty sands tested in literature.