Applicability of the methylated CpG sites of paired box 5 (PAX5) promoter for prediction the prognosis of gastric cancer

Abstract

Paired box gene 5 (PAX5), a member of the paired box gene family, is involved in control of organ development and tissue differentiation. In previous study, PAX5 promoter methylation was found in gastric cancer (GC) cells and tissues. At present study, we found that the inconsistently methylated levels of PAX5 promoter were identified in the different GC tissues. The methylated CpG site count and the methylated statuses of four CpG sites (-236, -183, -162, and -152) were significantly associated with the survival of 460 GC patients, respectively. Ultimately, the methylated CpG -236 was the optimal prognostic predictor of patients identified by using the Cox regression with AIC value calculation. These findings indicated that the methylated CpG -236 of PAX5 promoter has the potential applicability for clinical evaluation the prognosis of GC.

Methylation of ASC/TMS1 promoter is associated with poor prognosis of patients with gastric cancer

“…Akaike information criterion (AIC) of different variables in a Cox proportional hazard regression model was calculated to quantify the corresponding prognostic prediction abilities. A small AIC value indicated a good model for predicting outcomes [12]. The significance was set at p \ 0.05.…”

PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma

“…6 PAX5, located at chromosome 19p13, was originally identified as a B-cell-specific transcription factor required for B-cell differentiation 7 and neural development. 8 PAX5 gene methylation has been reported in various neoplasms, including HNSCC, 5 gastric cancer, 9 hepatoma, 10 breast cancer, and lung cancer. 11 PAX5 is also mutated in human acute B-cell leukemia.…”

Paired Box 5 Methylation Detection by Droplet Digital PCR for Ultra-Sensitive Deep Surgical Margins Analysis of Head and Neck Squamous Cell Carcinoma

“…It also plays a role in neural development and spermatogenesis. PAX5 gene methylation has been reported in various neoplasms including HNSCC(11), gastric cancer(12), hepatoma(13), breast cancer and lung cancer(14). In hepatocarcinogenesis, Liu et al, revealed that PAX5 directly binds to the p53 promoter and regulates p53 signaling.…”