Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Hou, Xian‐Geng; Qiu, Xinyu; Wang, Yaping; Song, Shuangshuang; Cong, Yifan; Hao, Jifu

doi:10.1155/2022/7135125

Cited by 11 publications

(11 citation statements)

References 43 publications

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“…Permeation studies revealed a 1.5-fold improvement in the penetration of elastic liposomes compared to simple liposomes. Increased skin hydration, coupled with the reinforcement of collagen fibers, indicated the restoration of skin elasticity upon treatment with MLT-EL in photoaging experiments [331].…”

Section: Melatoninmentioning

confidence: 92%

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Ashfaq,

Rasul,

Asghar

et al. 2023

IJMS

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Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs.

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Section: Melatoninmentioning

confidence: 92%

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Ashfaq,

Rasul,

Asghar

et al. 2023

IJMS

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“…The prepared elastic liposomes crossed the UV-induced photoaged skin layers of the female Kunming mice model more efficiently than liposomes utilized conventionally, improving dermal hydration and elasticity by maintaining collagen and fibers of derma during in vivo evaluation. Hence, it could be employed successfully for the future application for encapsulation of poorly soluble and low bioavailable therapeutic agents for treating skin diseases . Since the term “liposome” has a broad definition that encompasses several types of vesicles with typical sizes up to several micrometers, nanoliposomes have been referred to as nanoscale bilayer lipid vesicles .…”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

“…Hence, it could be employed successfully for the future application for encapsulation of poorly soluble and low bioavailable therapeutic agents for treating skin diseases. 176 Since the term “liposome” has a broad definition that encompasses several types of vesicles with typical sizes up to several micrometers, nanoliposomes have been referred to as nanoscale bilayer lipid vesicles. 177 Clove essential oil (CEO) and tea tree oil (TTO) were combined in varied concentrations and put into multicompositional nanoliposomes.…”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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“…Egrilmez et al (18) HDFs from 10 fe-males aged 20-40 years old with Fitz-patrick type III and IV -1 μM melatonin -0.1 J/cm 2 of UVB (311 ± 5 nm) for 6 s Melatonin inhibits UVBinduced oxidative/ nitrosative stress damage, downregulates UV-in-duced activation of EGFR and the c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) signaling pathway, decreases UVB-induced activities of matrix metalloproteinase (MMP)-1 and MMP-3, increases tissue inhibitor of metalloproteinase (TIMP)-1 and procollagen type I C-peptide (PIP-C). Hou et al (19) 30 Kunming female mice (35 ± 5 g) -300 µl melatonin elastic liposomes (MLT-ELs) -2 hours irradiation with UV lamp (223 nm) 30 cm away, for 10 weeks MLT-ELs ameliorate the skin elasticity, enhance the skin hydration level, and preserve the integrity of dermal collagen and elastic fibers.…”

Section: Melatonin-based Cream For 12 Weeksmentioning

confidence: 99%

Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging

Suyanto,

Widianti

2023

Univ Med

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The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.

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Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Cited by 11 publications

References 43 publications

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging

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