To examine the diffusion characteristics of airflow and dust particles, a multi-factor and multi-level physical self-developed testing system is established. In this study, bunker height, chute angle, feeding speed, coal granularity, and belt speed are selected as independent variables, and airflow velocity and dust concentration are the response variables. The two-factor interactive model is established to analyze the primary and secondary relationship between the independent variables and the response variables. The results demonstrate a denser contour distribution of three-dimensional curved surfaces, suggesting an obvious interaction between the factors. The bunker height increases from 0.75 m to 1.15 m, the maximum increment of the induced airflow velocity at the outlet of the guide chute is observed to be 0.35 m/s, meanwhile, and with the increase in the feed speed from 2t/h to 8t/h, the increment of the induced airflow velocity at the outlet of the guide chute is recorded to be 51%. The coal granularity and bunker height depicted the highest influence on induced air velocity and dust concentration, and the feeding speed proved to be the secondary parameter. This two-factor interactive model can accurately forecast the actual values with a deviation of the calculated values limited to 9%. These research results support the existing research and provide a theoretical foundation to guide the dust control at belt conveyor transfer stations.