Application and use of Inulin as a tool for therapeutic drug delivery

Imran, Shahwar; Gillis, Richard B.; Kök, Samil M.; Harding, Stephen E.; Adams, Gary G.

doi:10.5661/bger-28-33

Cited by 34 publications

(12 citation statements)

References 49 publications

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“…There is no valid way in which the bi- (or possibly tri-) modal c ( s ) distribution (right) can be transformed to yield even the relative masses of the two components, whereas with an estimate (0.60 ml/g) for the partial specific volume of the solute available, the (average) absolute molecular weights of the two species can be defined from the σ values associated with the peaks and their relative concentrations obtained even without that knowledge. Inulins, widely studied and used, usually have a major component with a molecular weight in the region of 5–6 kDa, sedimentation coefficient s 20,w ~0.7S (Imran et al 2012 ; Azis et al 1999 ). They readily degrade to smaller species, particularly at acidic pH levels (Windfield et al 2003 ).…”

Section: Resultsmentioning

confidence: 99%

MultiSig: a new high-precision approach to the analysis of complex biomolecular systems

et al. 2013

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MultiSig is a newly developed mode of analysis of sedimentation equilibrium (SE) experiments in the analytical ultracentrifuge, having the capability of taking advantage of the remarkable precision (~0.1 % of signal) of the principal optical (fringe) system employed, thus supplanting existing methods of analysis through reducing the ‘noise’ level of certain important parameter estimates by up to orders of magnitude. Long-known limitations of the SE method, arising from lack of knowledge of the true fringe number in fringe optics and from the use of unstable numerical algorithms such as numerical differentiation, have been transcended. An approach to data analysis, akin to ‘spatial filtering’, has been developed, and shown by both simulation and practical application to be a powerful aid to the precision with which near-monodisperse systems can be analysed, potentially yielding information on protein-solvent interaction. For oligo- and poly-disperse systems the information returned includes precise average mass distributions over both cell radial and concentration ranges and mass-frequency histograms at fixed radial positions. The application of MultiSig analysis to various complex heterogenous systems and potentially multiply-interacting carbohydrate oligomers is described.

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Section: Resultsmentioning

confidence: 99%

MultiSig: a new high-precision approach to the analysis of complex biomolecular systems

et al. 2013

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“…Inulin has been widely used as a prebiotic for many decades because it promotes the growth and activity of probiotic L. reuteri [29]. It has also been used in drug delivery systems for intranasal, parenteral, intravenous, and subcutaneous routes of administration [30] although inulin itself is difficult to use as a carrier in an oral colonic drug delivery system because inulin is highly soluble in water. Therefore, many strategies have been tried to reduce the solubility of inulin in water by mixing hydrophobic coating materials such as Eudragit [31,32] or by conjugating hydrophobic residues [33].…”

Section: Discussionmentioning

confidence: 99%

Oral Delivery of Probiotics Using pH-Sensitive Phthalyl Inulin Tablets

Kim¹,

Cho²,

Liang³

et al. 2019

Journal of Microbiology and Biotechnology

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Probiotics show low cell viability after oral administration because they have difficulty surviving in the stomach due to low pH and enzymes. For the oral delivery of probiotics, developing a formula that protects the probiotic bacteria from gastric acidity while providing living cells is mandatory. In this study, we developed tablets using a new pH-sensitive phthalyl inulin (PI) to protect probiotics from gastric conditions and investigated the effects of different compression forces on cell survival. We made three different tablets under different compression forces and measured survivability, disintegration time, and kinetics in simulated gastric-intestinal fluid. During tableting, there were no significant differences in probiotic viability among the different compression forces although disintegration time was affected by the compression force. A higher compression force resulted in higher viability in simulated gastric fluid. The swelling degree of the PI tablets in simulated intestinal fluid was higher than that of the tablets in simulated gastric fluid due to the pH sensitivity of the PI. The probiotic viability formulated in the tablets was also higher in acidic gastric conditions than that for probiotics in solution. Rapid release of the probiotics from the tablet occurred in the simulated intestinal fluid due to the pH sensitivity. After 6 months of refrigeration, the viability of the PI probiotics was kept. Overall, this is the first study to show the pH-sensitive properties of PI and one that may be useful for oral delivery of the probiotics.

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“…It possesses an extensive range of therapeutic uses because of its pharmacological inertness. Inulin has been extensively used as a drug delivery agent, as a diagnostic/analytical tool, or as a dietary fiber with additional health benefits due to its rapid water solubility, low friability, and stability against gastric and intestinal enzymes [1][2][3]. Its isoforms (especially gamma-and delta-inulins) are successfully used in pharmacy as vaccine adjuvants [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Its isoforms (especially gamma-and delta-inulins) are successfully used in pharmacy as vaccine adjuvants [4][5][6]. Many researchers have focused on inulin as a drug carrier for colon-targeted drug delivery [1,3,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Inulin can be used for encapsulation purposes, especially in oregano oil [8], catechins, or thyme extracts, as an active ingredient [9,10] or as a coating material of tablets, capsules, tablet binder, and a vaccine stabilizer [1,11]. Inulin has also been used to stabilize membranes, proteins, and several pharmaceutically relevant systems, unstable drugs [1,2]. It possessed solubility better than drugs and this property is dependent on inulin molecular weight [12].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Inulin From Black Salsify (Scorzonera Hispanica L.) for Food and Pharmaceutical Purposes

Petkova

2018

Asian J Pharm Clin Res

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Objective: The aim of the current study was to evaluate the black salsify (Scorzonera hispanica L.) as a potential source of inulin and to characterize the physicochemical properties of isolated polysaccharide.Methods: The carbohydrate content in its roots and leaves was analyzed by high-performance liquid chromatography with refractive index detection (HPLC-RID) method. Microwave-assisted extraction was performed for isolation of inulin from black salsify roots. The obtained polysaccharide was characterized by HPLC-RID method, HPLC size-exclusion chromatography, and Fourier transformed-infrared spectroscopy. Functional properties as swelling capacity, solubility, and water-holding and oil-holding capacities (OHCs) were also evaluated.Results: Black salsify (S. hispanica L.) roots were evaluated as a rich source of inulin (22% dw) and 1-kestose (6.25 g/100 g dw). The isolated inulin (yield 20%) was characterized with average degree of polymerization 17, with polydispersity index (1.04) that was near to medium-chained inulin. This polysaccharide showed better OHC than water-holding capacity, and it was characterized with swelling capacity 0.5 ml/g sample.Conclusion: For the first time, inulin was isolated from black salsify roots. The chemical characterization of inulin reveals the potential of this plant to be used as a valuable source of this polysaccharide for future application in food technology and pharmaceutical industry for dietary fibers, stabilizer, and coating agent.

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Application and use of Inulin as a tool for therapeutic drug delivery

Cited by 34 publications

References 49 publications

MultiSig: a new high-precision approach to the analysis of complex biomolecular systems

MultiSig: a new high-precision approach to the analysis of complex biomolecular systems

Oral Delivery of Probiotics Using pH-Sensitive Phthalyl Inulin Tablets

Characterization of Inulin From Black Salsify (Scorzonera Hispanica L.) for Food and Pharmaceutical Purposes

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