Application d’un modèle hybride à l’étude des dommages radio-induits par un faisceau d’électrons sur la molécule d’ADN dans son environnement

Djamai, D.; Oudira, H.; Saifi, A.

doi:10.1051/radiopro:2008005

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Indeed, this radionuclide emits by de-excitations a series of low-energy electrons, causing damage near to the site of decay. To reduce the computation time associated with the stochastic approach, we simulate the indirect effect of de-excitations through the diffusion equation [6][7]. …”

Section: Problem Positionmentioning

confidence: 99%

Development of a hybrid model to quantify the single and double strand breaks following the iron 57 de-excitation

Oudira¹,

Lotfi²,

Safi³

2017

Pressacademia

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The therapeutic utility of certain Auger emitters such as iodine-125 depends on their position within the cell nucleus. Or diagnostically, and to maintain as low as possible cell damage, it is preferable to have radionuclide localized outside the cell or at least the core. One solution to this problem is to consider markers capable of conveying anticancer drugs to the tumor site regardless of their location within the human body. The objective of this study is to simulate the impact of a complex such as bleomycin on single and double strand breaks in the DNA molecule. Indeed, this simulation consists of the following transactions: Construction of BLM -Fe-DNA complex, simulation of the electron's transport from the metastable state excitation of Fe 57 by the Monte Carlo method, treatment of chemical reactions in the considered environment by the diffusion equation. For physical, physico-chemical and finally chemical steps, the geometry of the complex is considered as a sphere of 50 nm centered on the binding site , and the mathematical method used is called step by step based on Monte Carlo codes. ________________________________________________________________________________________________________________

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Section: Problem Positionmentioning

confidence: 99%